Lutathera (lutetium Lu 177 dotatate) Cost, Side effects, Dosage, Uses

Lutathera (lutetium Lu 177 dotatate) Cost, Side effects, Dosage, Uses. The FDA granted the approval of Lutathera to Advanced Accelerator Applications.

Lutathera is a drug designed to treat cancer specially gastroenteropancreatic neuroendocrine tumors involving pancreas, stomach, intestines, rectum, colon and any other region in gastrointestinal tract. It also include pancreatic neuroendocrine tumors which have somatostatin receptors. It is a radioactive drug with active ingredient lutetium 177 dotatate. Pancreatic neurocrine tumors are most common tumors above all other pancreatic tumors. Lutathera drug belongs to pharmacological class of somatostatin analogs. Somatostatin is a primary hormone which actively binds to somatostatin receptors and leads to production and release of secondary hormones.

It is the 1st ever radioactive drug introduced and also known as radiopharmaceutical. There are two main reasons behind approval of this drug 1st one is randomized clinical trial which consist of 229 patients treated with Lutathera drug and chemotherapy drug i.e. octreotide. In this case, Lutathera increased progression free survival rate of patients. 2nd reason is clinical trials based on 360 patients and only Lutathera drug is administered. As a result tumor got shrink in about 16 percent of patients.


Lutathera (lutetium Lu 177 dotatate) Cost, Side effects, Dosage, Uses

Lutathera Mechanism of Action

         
Lutathera drug is a radioactive drug which is used to treat cancer of gastroenteropancreatic neuroendocrine.it is a peptide receptor radionuclide therapy. It belongs to pharmacological class of somatostatin analogs. It is a type of hormone which primarily bind to somatostatin receptor and leads to production or release of secondary hormones. Lutathera drug bind to these receptors as a somatostatin analog and change the level of secondary hormones. This change in level of secondary hormone will reduce symptoms of tumor as well as slow down the growth of cancer cells present in certain organs.


Lutathera Dosage

         
Lutathera drug is available in the form of an intravenous dosage form. It is available in two strengths i.e. 370 mBq/ml single dose vial and in each vial solution volume is adjusted from 20.5 to 25 ml in order to provide 7.4 GBq of radioactivity per vial. In case of neuroendocrine tumors, 7.4 GBq IV 4 times a day for about 8 weeks is administered with other medications. Dose adjustment is required in case of renal and hepatic impairment, pregnancy and lactation, thrombocytopenia, anemia and neutropenia, renal toxicity, hepatotoxicity and other non-hematological toxicity.


Lutathera Uses

         
Lutathera drug is a radioactive drug used for treatment of gastroenteropancreatic neuroendocrine tumors. It is administered with pre medications and concomitant medications. Long acting somatostatin analog should discontinue at least 4 weeks before Lutathera drug treatment. Patient can take small acting octreotide if required. During Lutathera treatment, long term Lutathera can be administered. If antiemetic are prescribed, then it should be administer almost 30 min before lutetium treatment. Amino acid solution in intravenous form should be initiated before Lutathera treatment. A 3 way valve is used for this purpose to inject both solutions via same venous access.

Lutathera Side effects


Side effects of Lutathera involves high level of working enzymes in associated organs, level of white blood cells become low, high blood sugar level, vomiting, nausea and last but not least high level of potassium in blood.


Lutathera Cost


Lutathera cost is difficult to evaluate at the moment as according to market survey this drug is currently not available at retail pharmacies because it is recently approved by FDA and is under manufacturing process. Once, it will be available at retail outlets we will let you know about the unit cost of drug and its dosage frequency.

Biktarvy Cost, Side Effects, Dosgae, Uses

Biktarvy Cost, Side Effects, Dosgae, Uses. US FDA granted approval of Biktarvy to Gilead Sciences, Inc.

Biktarvy drug is the combination of three active ingredients i.e. bictegravir, emtricitabine and tenofovir alafenamide. It is recently approved by food and drug administration on February 7, 2018. It is available in the form of tablet. Biktarvy drug is specially designed for the treatment of HIV infection. Many clinical trials are performed globally and then finally biktarvy drug is approved by food and drug administration with its side effects and adverse effects. Where it is active against HIV infection, there are also some side effects associated with it like worsening of hepatitis B virus infection.

It is not used with other drugs of HIV 1 infection in adults. HIV 1 is a virus which causes AIDS. AIDS is abbreviated as Acquired Immune Deficiency Syndrome). It is still unknown that whether this drugs is safe in children or not. Biktarvy drug is contraindicated with dofetilide and rifampin. Lactation or breast feeding is prohibited while taking Biktarvy drug. Adverse effects of biktarvy was observed in only 5 percent of patients involved in clinical trials.


Biktarvy Cost, Side Effects, Dosgae, Uses

Biktarvy Mechanism of Action

       
Biktarvy drug is designed in a fixed dose combination of bictegravir, emtricitabine and tenofovir alafenamide. It is the combination of HIV 1 (human immunodeficiency virus 1) integrase strand transfer inhibitor (INSTI). It also works as two human immunodeficiency virus type 1 nucleoside analog reverse transcriptase inhibitor (NRTI’s). It acts as a nucleoside and inhibit the process of reverse transcription. With the help of these two main functions it actively treat HIV 1 infection especially in adults. Active ingredients used in biktarvy drug work collectively with their specific mechanism of action.

Biktarvy Drug Dose

       
Biktarvy is a fixed dose combination drug of bictegravir 50 mg, emtricitabine 200 mg and tenofovir alafenamide 25 mg. biktarvy drug is recommended to administer 1 tablet per day which can be taken with food or without food. Biktarvy drug is contraindicated with some drugs like anti-retroviral drugs i.e. rifampin, metformin, acyclovir, Val acyclovir, gentamicin and dofetilide. Dose adjustment is required in case of hepatic impairment, renal abnormality, pregnancy and lactation. Physician recommend not to take biktarvy drug in case of pregnancy and lactation because one of its active ingredient can pass placental barrier and transfer to fetus.


Biktarvy Drug Uses

     
It is a specially designed complete regimen for treatment of human immunodeficiency virus type 1 infection. Its active ingredients belongs to pharmacological class of human immunodeficiency virus type 1 integrase strand transfer inhibitor and nucleoside reverse analog reverse transcriptase inhibitors. This drug is used in adults who are not taking other anti-retroviral drugs not even in past. There are some limitations in its use like it is not recommended in patients who are virologically suppressed, in patients who are using substitutes of one of its active ingredients, in patients with no treatment failure history of anti-retroviral therapy.

Biktarvy Side effects

Adverse reactions of this drug are as follows.

Nausea, headache, renal impairment can occur or worsen the pre-existing renal impairment, diarrhea, HBV exacerbation, lactic acidosis, immune reconstitution syndrome and hepatomegaly.

Biktarvy Cost

Biktarvy cost is difficult to evaluate at the moment as according to market survey this drug is currently not available at retail pharmacies because it is recently approved by FDA and is under manufacturing process. Once, it will be available at retail outlets we will let you know about the unit cost of drug and its dosage frequency.

Symdeko (tezacaftor & ivacaftor) Cost, Side Effects, Dosage, Uses

Symdeko (tezacaftor & ivacaftor) Cost, Side Effects, Dosage, Uses. US FDA granted approval of Symdeko to Vertex Pharmaceuticals Inc.

Symdeko drug is vertex’s third drug which is the combination of tezacaftor and ivacaftor. It is approved by Food drug authority for treatment of leading cause of cystic fibrosis. It is effective in patients with 12 years of age and older. It is specifically designed for patients having a pair of copies of F508del mutation in CFTR protein. CFTR is abbreviated as cystic fibrosis conductance regulator (It is a protein which works as a channel in transporting salt and water in and out of cell.) Symdeko is also effective in patients with at least one gene mutation.

It is approved after 3 global clinical trials involving 750 patients. Symdeko is contraindicated with some antibiotics like rifampin, rifabutin, medicines used in seizures i.e. phenobarbital, carbamazepine or phenytoin. Some of its factors are still unknown like if it pass on to infant during pregnancy and lactation. Dose adjustment of Symdeko is also required when other drugs are in prescription. Symdeko also have some side effect i.e. dizziness so patient should avoid activities which require attention like driving or running a machine. Other side effects involve abnormality of eye lens and high level liver enzymes in blood. Grapefruit juice and orange juice is contraindicated with Symdeko.

Symdeko (tezacaftor & ivacaftor) Cost, Side Effects, Dosage, Uses

Symdeko Mechanism of Action

       
 Normally CFTR (cystic fibrosis conductance regulator) is a protein which acts as a channel on the cell surface. It is responsible for transportation of salt and water molecule. But in cystic fibrosis, this specific protein is missing or not in a working position. This improper working leads to formation of a thick, sticky mucus which can effect multiple organs including lungs. Active ingredients of Symdeko works separately i.e. tezacaftor helps CFTR protein to move towards cell surface and ivacaftor help this protein to be open for longer time.

Symdeko Dosage

       
Dose adjustment of Symdeko drug is important to get optimum response. As two drugs are combined in Symdeko, so dosage of each drug is designed to get desired effect. Tezacaftor 100 mg is adjusted with 150 mg of ivacaftor in single tablet of Symdeko. Dose adjustment is required If Symdeko is administered with other drugs like anti-fungal i.e. ketoconazole, itraconazole, posaconazole, voriconazole or fluconazole and some antibiotics like telithromycin, erythromycin or clarithromycin. Dosage adjustment is also required if patient is suffering from a kidney or liver disease. In pregnancy and lactation Symdeko should be avoided.


Symdeko Uses

       
Symdeko drug is specially designed to treat cystic fibrosis in patient with 12 years of age or above. A specific dosage combination is required for treating cystic fibrosis. In this drug, tezacaftor and ivacaftor are working collectively to regulate CFTR protein. But these two active ingredients if with different strength are combined, will be effective against HIV 1 infection. These are used as three months regimen for complete cure. These are the only two main diseases in which tezacaftor and ivacaftor are used in fixed dose combination for treatment. Further uses of tezacaftor and ivacaftor combination are not reported yet.

Symdeko Side effects


According to health authorities following side effects might be associated with use of this drug.

  • Increased Liver Enzymes
  • Nausea
  • Vomiting
  • Headache
  • Sinus Congestion
  • Dizziness
  • Palpitation
  • Rashes

Symdeko Cost

Symdeko cost is difficult to evaluate at the moment as according to market survey this drug is currently not available at retail pharmacies because it is recently approved by FDA and is under manufacturing process. Once, it will be available at retail outlets we will let you know about the unit cost of drug and its dosage frequency.