Rhopressa/netarsudil Cost, Side effects, Dosage, Uses

Rhopressa/netarsudil Cost, Side effects, Dosage, Uses.

Rhopressa is a brand name of a drug which is prepared in fixed combination of netarsudil/latanoprost agent. It is used to treat glaucoma specifically open angle glaucoma also known as ocular hypertension. Glaucoma can be treated via lowering the level of intra ocular pressure or by creating a better drainage system of fluid from eye. This can be possible via one or combining both of pathways i.e. trabecular meshwork pathway (schlemm’s canal) and uveoscleral pathway. Intraocular pressure can be lowered with eye drops, laser or incisional eye surgery. The most common treatment method used is eye drops.

With the passage of time, patient have to instill multiple types of eye drops to stop the progression of disease. Currently in United States, about 5 drug families are in use to lower the level of intra ocular pressure. Rhopressa is one of them. There are some precautions regarding use of Rhopressa. It contains benzalkonium chloride which may readily absorbed by contact lenses so if patient is wearing any soft contact lenses, he have to take them off before instillation of eye drops of Rhopressa. After 15 minutes of administration of Rhopressa eye drops, patient can re wear soft contact lenses.


Rhopressanetarsudil Cost, Side effects, Dosage, Uses


Rhopressa/netarsudil Mechanism


Rhopressa is most commonly used drug to treat open angle glaucoma or ocular hypertension. The basic function of Rhopressa is to lower the level of intra ocular pressure. So mechanism via which it lowers intraocular pressure is inhibition of Rho kinase. It is a dual inhibitor because it also inhibits epinephrine plasma membrane protein along with Rho kinase. When it inhibits these two processes, on the other hand it increases trabecular outflow. The absorption of Rhopressa gives plasma concentration after about 8 days and it gets metabolize through estrases present in eye.

Rhopressa/netarsudil Dosage

         
Rhopressa is available in the form of ophthalmic solution concentration 0.02% (0.2mg/ml). Patient have to instill 1 drop in affected eye daily. It is recommended to administer in evening. If patient miss any dose then treatment should not be quit but it can be continued with next dose in evening. Precautions should be followed while administering Rhopressa drug. Like patient should try to instill drop directly into eye to avoid contamination and should take off soft contact lenses before administration in order to avoid absorption of benzalkonium chloride in lenses. If multiple drug drops are in treatment then there should be 5 min gap between every administration.


Rhopressa/netarsudil Side effects

         
Rhopressa is widely used drug as a treatment of open angle glaucoma but it also impart side effects along with its beneficial effects. The most common side effects reported by patients are redness in eye, pain in the area of instillation of eye drops. Hemorrhage may occur in conjunctiva. Corneal verticillata is also reported in many cases. Corneal staining, reduced visual acuity, erythema of eyelid, lacrimation may increase, vision may get blurred right after administration and persist for some time. Eye erythema at the site of instillation.


Rhopressa/netarsudil Uses/Prescribing Information


This new drug application provides for the use of Rhopressa (netarsudil ophthalmic solution)
0.02% for the reduction of elevated intraocular pressure in patients with open-angle glaucoma or
ocular hypertension. We have completed our review of this application, as amended.

Rhopressa/netarsudil Cost


Rhopressa/netarsudil cost is difficult to evaluate at the moment as according to market survey this drug is currently not available at retail pharmacies because it is recently approved by FDA and is under manufacturing process. Once, it will be available at retail outlets we will let you know about the unit cost of drug and its dosage frequency.

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