Verzenio/abemaciclib Cost, Side effects, Dosage, Uses for certain advance Cancers

Verzenio/abemaciclib Cost, Side effects, Dosage, Uses for certain advance Cancers.The FDA granted the approval of Verzenio to Eli Lilly and Company.

US FDA approved new drug Verzenio that contains active pharmaceutical ingredient abemaciclib for the treatment of certain advance metastatic cancers like hormone receptor positive, human epidermal growth factor receptor 2 (HER2) negative advanced or metastatic breast cancer. US FDA approved this in combination with other drug fulvestrant if there is not adequate response after administering endocrine therapy.

Though it is not first kind of therapy approved by US FDA that belongs to CDK inhibitors but according to US FDA statement this drug provides targeted  treatment option for certain patients with breast cancer who are not responding to treatment, and unlike other drugs in the class.

Breast cancer is one the highly prevailing cancer among women and spreads rapidly. Early detection of such kind of cancers is very important factor in defining prognosis, survival rate and life expectancy. Proper screening and following provided guidelines play important role in prevention and early detection of such disorders.

Verzenio/abemaciclib belongs to a class known as CDK inhibitors (cyclin dependent kinase inhibitors) but it specifically causes inhibition of CDK4 and CDK6. These molecules CDK4 and CDK6 play important role in the development of cancerous cells that's why their inhibition provides better control over disease
progression.

Verzenio/abemaciclib Cost, Side effects, Dosage, Uses for certain advance Cancers


Verzenio/abemaciclib Side effects


According to health authorities following side effects were observed during clinical trails

Common Side effects
  • Nausea
  • Vomiting
  • Abdominal Discomfort
  • Diarrhea
  • Weakness
  • Palpitations
  • Low white blood cell count
  • Loss of appetite
  • Headache
Serious or Severe side effects
  •  Elevated liver Enzymes
  • Clotting (Thrombosis)
  • Hypersentivity reaction
  • Anaphylaxis

Verzenio/abemaciclib Uses


Verzenio/abemaciclib is approved for the treatment of certain advance metastatic cancers like hormone receptor positive, human epidermal growth factor receptor 2 (HER2) negative advanced or metastatic breast cancer. US FDA approved this in combination with other drug fulvestrant if there is not adequate response after administering endocrine therapy.

Verzenio/abemaciclib Dosage


Verzenio/abemaciclib is formulated in tablet form for oral administration in following strength 50mg, 100mg, 150mg, 200mg. Recommended dosing frequency of Verzenio/abemaciclib is 200mg twice daily as mono therapy or 150mg twice daily in combination with fulvestrant.

Verzenio/abemaciclib Cost


Verzenio is now available at retail outlets with average cost of 6000$ - 6200$ per pack that contains 30 tablets each with potency of 150mg. This cost may variate with the passage of time so, make it confirm by visiting your nearby pharmacy before purchasing.

Mvasi Cost, Side effects, Dosage, Uses for Cancer

Mvasi Cost, Side effects, Dosage, Uses for cancer. The FDA granted approval of Mvasi to Amgen, Inc. Avastin was approved in February 2004 and is manufactured by Genentech, Inc.

US FDA approved first biosimilar drug Mvasi/bevacizumab-awwb for the treatment of different kind of cancers. Mvasi is quite equal in efficacy to already present reference product Avastin (Genetech/Roche) which was approved by US FDA in 2004. Mvasi has same indications like the reference product Avastin (Genetech/Roche). Mvasi/bevacizumab-awwb major indications include colon cancer, non-small cell lung cancer, glioblastoma, ovarian cancer, breast cancer and renal cell carcinoma. US FDA approved this biosmilar drug on the basis of cost difference because biosimilars are expected to be cheaper but their safety profile, indications and adverse effects are quite similar to reference product.

Cancer is one of the leading cause of death across the globe. Some tumors are not metastatic and less dangerous as compared to other metastatic cancers. Each cancer might have different sign and symptoms as compared to other one but as a general some commonly observed symptoms of cancer are consistent weight loss, sweating during night time, bleeding, formation of lumps, changes in bowel movements. Some kind of viral infections may also lead to cancer if persist for a longer period of time.

Rigorous research is still on the way to find complete cure of cancer. Etiology of each cancer might be different but certain risk factors like genetic predisposition, exposure to radiations and chemicals, chronic viral infections, sedentary life style, obesity, smoking, alcoholism and environmental pollution play important role in its development.

Mvasi Cost, Side effects, Dosage, Uses for Cancer


Mvasi Side effects


Some commonly observed side effects during this drug therapy include
  • Bleeding or hemorrhage
  • Hypertension
  • Nasal cavity swelling
  • Loss of protein through urine
  • Rashes
  • Changes in mouth taste
  • Nausea
  • Vomiting
  • Abdominal Discomfort
  • Dryness of skin
  • Excessive lacrimation
  • Skin allergy

Mvasi Uses


US FDA approved Mvasi for the treatment of Metastatic colorectal cancer in combination with other drugs or as second line therapy, non-squamous non-small cell lung cancer, glioblastoma in aggressive stage, metastatic renal cell carcinoma and cervical cancer.

Mvasi Dosage


Metastatic colorectal cancer
  • 5 mg/kg IV every 2 weeks with bolus-IFL
  • 10 mg/kg IV every 2 weeks with FOLFOX4
  • 5 mg/kg IV every 2 weeks or 7.5 mg/kg IV every 3 weeks with
fluoropyrimidine-irinotecan or fluoropyrimidine-oxaliplatin based chemotherapy after progression on a first-line bevacizumab product containing regimen.

Non-squamous non-small cell lung cancer 
  • 15 mg/kg IV every 3 weeks with carboplatin/paclitaxel
 Glioblastoma
  • 10 mg/kg IV every 2 weeks
Metastatic renal cell carcinoma (mRCC)
  • 10 mg/kg IV every 2 weeks with interferon alfa Persistent, recurrent, or metastatic carcinoma of the cervix
  • 15 mg/kg IV every 3 weeks with paclitaxel/cisplatin or paclitaxel/topotecan 

Mvasi Cost 


Mvasi cost is difficult to evaluate at the moment as according to market survey this drug is currently not available at retail pharmacies because it is recently approved by FDA and is under manufacturing process. Once, it will be available at retail outlets we will let you know about the unit cost of drug.

Aliqopa/Copanlisib Cost, Side effects, Dosage, Uses for relapsed follicular lymphoma

Aliqopa/Copanlisib Cost, Side effects, Dosage, Uses for relapsed follicular lymphoma. The FDA granted the approval of Aliqopa to Bayer Healthcare Pharmaceuticals, Inc.

US FDA approved new drug Aliqopa that contains active pharmaceutical ingredient copanlisib for the treatment of recurrent or relapsed follicular lymphoma in adult patients. Aliqopa basically belongs to a class known as Class I phosphoinositide 3-kinase inhibitors. US FDA granted accelerated approval of Aliqopa due to its effective response rate.

Follicular lymphoma is a characterized as type of blood cancer in which body synthesize abnormal B lymohocytes that fight against infection and diseases. Abnormal B lymphocytes turned into lymphoma cells and builds up in lymph nodes. This is slow growing form of blood cancer and also categorized as non-Hodgkin lymphoma. Some commonly observed symptoms of follicular lymphoma are tenderness, consistent weight loss, sweating during night time, palpitations, low grade fever, generalized weakness and weak immunity.

Exact underlying cause of follicular lymphoma is not yet well understood. However, many researchers and scientists believe that genetic predisposition, continuous exposure to toxic chemicals, radiations, environmental factors and sedentary lifestyle are main leading causes of follicular lymphoma. Proper diagnosis can only be done via lymph nodes biopsy. Radioactive scans can also be used to
to diagnose follicular lymphoma.

Aliqopa/Copanlisib mechanism of action is that it inhibits proliferation of primary malignant B cell lines and causes death of tumor cells via apoptosis. Aliqopa/Copanlisib also blocks several pathways like  B-cell receptor (BCR) signaling that triggers proliferation of  lymphoma cells.

Aliqopa/Copanlisib Cost, Side effects, Dosage, Uses for relapsed follicular lymphoma

Aliqopa/Copanlisib Side effects


According to health authorities following side effects were noted during clinical trials of Aliqopa/Copanlisib.
  • Increase blood glucose levels
  • Diarrhea
  • Skin rashes
  • Generalized weakness
  • High blood pressure
  • Nausea
  • Vomiting
  • Anemia
  • Increase susceptibility to infection
  • neutropenia

Aliqopa/Copanlisib Uses or Prescribing Information


US FDA approved this drug for the treatment of  relapsed follicular lymphoma (FL) in adult patients who have received at least two prior systemic therapies. Withhold drug  in case of severe infection of hyperglycemia until they completely resolved.

Aliqopa/Copanlisib Dosage


Aliqopa/Copanlisib is formulated in the form of injection for parenteral administration in single dose vial containing 60 mg Aliqopa/Copanlisib as a lyophilized solid  for reconstitution. Standard dosage frequency of Aliqopa/Copanlisib is 60mg intravenously in 1 hour on first day of therapy then repeat it on day 8 and 15.

Aliqopa/Copanlisib Cost



This drug is administered by your healthcare practitioner (HCP), which usually means:
  • It may comes under special items category.
  • You cannot fill this prescription in a regular pharmacy. Your doctor, hospital, or clinic will provide this  medication because of possible complications or other issues.
  • This drug is likely to be covered under your medical benefit if you have insurance.

Benznidazole Cost, Side effects, Dosage, Uses for Chagas disease

Benznidazole Cost, Side effects, Dosage, Uses for Chagas disease. FDA granted approval of Benznidazole to Chemo Research, S.L.

US FDA approved new drug that that contains active pharmaceutical ingredient Benznidazole for the treatment of Chagas disease in pediatric patients having age 2 to 12 years. This is first kind of therapy approved by US FDA for the treatment of chagas in pediatric patients.

Chagas disease is also termed as American trypanosomiasis is a kind of rare tropical parasitic disease causes by parasite known as trypanosoma cruzi. Insects or bugs like triatominae are carriers of such parasite and when they bite or suck blood from human body this parasite gets enter into blood stream. Commonly observed symptoms are fever, swelling and enlargement of lymph nodes, body pain, headache and swelling in extremities.

This parasite may also cause infection in animals (mammals) if it enters into their blood stream. Other source of transmission of this disease are contaminated blood transfusion, transplantation of organ for carrier donor, eating food that contains such parasite and vertical transmission is also possible in case of chagas disease.

Benznidazole is anti-parasitic drug that belongs to a medicinal class known as nitroimidazole. It works by releasing radical species that binds with parasite DNA and damage it. This will decrease the proliferation parasite inside the blood and ultimately disease spread will be reduce.

Benznidazole Cost, Side effects, Dosage, Uses for Chagas disease


Benznidazole Side effects


According to health authorities following side effects were observed during clinical of this drug.

  • Abdominal Pain
  • Rash
  • Weight loss
  • Headache
  • Nausea
  • Vomiting
  • Neutropenia
  • Itching
  • Loss of appetite

Benznidazole Uses



US FDA approved benznidazole for the treatment of Chagas disease in pediatric patients having age 2 to 12 years.  Breastfeeding is not recommended during administration of benznidazole.  This drug may interact with disulfiram so, there must be a gap of 2 weeks between these two therapies to avoid undesirable effects.


Benznidazole Cost and Dosage


Benznidazole cost is difficult to evaluate at the moment as according to market survey this drug is currently not available at retail pharmacies because it is recently approved by FDA and is under manufacturing process. Once, it will be available at retail outlets we will let you know about the unit cost of drug and its dosage frequency.

Mylotarg Cost, Side effects, Dosage, Uses for acute myeloid leukemia

Mylotarg Cost, Side effects, Dosage, Uses for acute myeloid leukemia. The FDA granted the approval of Mylotarg to Pfizer Inc.

US FDA approved drug Mylotarg that contains active pharmaceutical ingredient gemtuzumab ozogamicin which is monoclonal antibody for the treatment of acute myeloid leukemia in CD33-positive AML patients. In past, this drug was voluntarily withdrawn from market in 2010 because the drug was failed to verify clinical benefits after subsequent confirmatory trials. The drug will be again in market after 7 years of absence following its approval by US FDA on September 1, 2017.

Acute myeloid leukemia (AML) is a kind of cancer that targets white blood cells. In this disease mutation occurs in specific genes due to which bone marrow produce abnormal and immature white blood cells that are physiologically non-functional. Onset of symptoms include mild to moderate fever, busing, asthenia (loss of energy), muscular pain. In later stages, internal hemorrhage may leads to bleeding inside the body. Proper diagnosis of can only done via blood tests or bone marrow biopsy.

Research is still underway to find out exact underlying cause that trigger mutations and mediates the pathophysiology this disease. Many scientists believe that certain factors like genetic predisposition, exposure to radiations and chemicals, smoking play important in the pathophysiology of disease. Some viral infections of bone marrow may also trigger such kind of disease if they persist for longer duration of time.

Mylotarg/Gentuzumab ozogamicin is a combination of humanized monoclonal antibody (Gentuzumab) specifically designed to bind with CD-33 and second drug is cytotoxic anti-tumor antibiotic calicheamicin. After administration it readily binds with CD-33 and then ozogamicin exerts its anti-tumor antibiotic effects.

Mylotarg Cost, Side effects, Dosage, Uses for acute myeloid leukemia

Mylotarg Side effects


According to health authorities this drug may exhibit following side effects after its administration
  • Pyrexia
  • Increase susceptibility to infections
  • Nausea
  • Vomiting
  • Elevated level of liver enzymes
  • Rashes
  • Swelling in extremities
  • Hypersensitivity
  • Mouth Ulcers
  • Hemorrhage
  • Blockage of the veins

Mylotarg Uses


US FDA approved Mylotarg for the treatment of for the treatment of acute myeloid leukemia in CD33-positive AML patients. The drug has also been approved for the treatment of CD33-positive AML in both pediatric and adult patients who have experienced a relapse or who have not responded to initial treatment.

Mylotarg Dosage


Mylotarg is formulated as single dose vial that contains 4.5mg lyophilized cake powder for reconstitution. Standard dosage frequency of Mylotarg is  3 mg/m2 (up to one 4.5 mg vial) on Days 1, 4, and 7 in combination with daunorubicin.

Mylotarg Cost



This drug is administered by your healthcare practitioner (HCP), which usually means:
  • It may comes under special items category.
  • You cannot fill this prescription in a regular pharmacy. Your doctor, hospital, or clinic will provide this  medication because of possible complications or other issues.
  • This drug is likely to be covered under your medical benefit if you have insurance.