Endari Cost, Side effects, Dosage, Uses for sickle cell disease

Read about Endari Cost, Side effects, Dosage, Uses for sickle cell disease. The FDA granted the approval of Endari to Emmaus Medical Inc.

US FDA approved a new drug Endari that contains L-glutamine for oral administration for the treatment of sickle cell disease in patients having age 5 years or more. Sickle cell disease is a severe kind of hematological disorder. Endari is first kind of drug approved by US FDA to reduce complications and severity of symptoms associated with sickle cell disease.

Sickle cell disease is characterized as a group of hematological disorders that occur due to genetic mutations. Most commonly occurring form of sickle cell disease is sickle-cell anemia (SCA) in which patient have abnormal shaped RBC's that are either immature or non-function. Basic reason behind sickle cell anemia is mutation of hemoglobin that carries oxygen and supplies it to tissues of  whole body.

Symptoms associated with sickle cell disease are anemia, swelling of extremities, increase susceptibility to infection, hypoxia, acute chest syndrome, haemolytic crisis and moderate to severe pain. Patient having sickle cell disease must be vaccinated properly to minimize chances of common infection. Moreover, patient should be nourished well and remain hydrated. Supplements that contain high amount folic acid are also beneficial because folic is required for production of RBC's.

According to data provided by health authorities it has been observed that patients receiving Endari have less complications as compared to patients who were taking placebo. Similarly, patients receiving Endari have experienced fewer hospital visits for pain treatment.

Endari Cost, Side effects, Dosage, Uses for sickle cell disease


Endari Side effects


During clinical trial following side effects were observed induced by Endari.

  • Abdominal Pain
  • Constipation
  • Headache
  • Cough
  • Nausea
  • Vomiting
  • Chest pain
  • Extremities pain
  • Abdominal Bloating

Endari Uses/Patient Information


This is first drug approved by US FDA to reduce complications associated with sickle cell disease like body pain, chest pain, hypoxia etc.  US FDA approved this drug for patient having age 5 years or more.  Endari is administered via oral route in the form of powder.


 Endari Dosage


Enadri is formulated as powder for oral administration with potency of 5g L-glutamine/packet. However, it's dosage frequency for those who have body weight less than 30Kg is 5g L-glutamine powder orally two times a day. For those who have 30-65Kg weight dose will be 10g L-glutamine powder orally twice a day. Similarly, for those who have weight 65Kg or above dose will be 10g L-glutamine powder orally twice a day.

Endari Cost/Price


According to market survey this drug is currently not available at retail pharmacies because it is recently approved by FDA and is under manufacturing process. Once, it will be available at retail outlets we will let you know about the unit cost of drug and its dosage frequency.

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