Baxdela/delafloxacin Cost, Side effects, Dosage, Uses

Baxdela/delafloxacin Cost, Side effects, Dosage, Uses. The FDA granted approval of Baxdela to Melinta Therapeutics, Inc.

US FDA approved new drug Baxdela that contains delafloxacin as an active pharmaceutical ingredient for the treatment of Acute Bacterial Skin and Skin Structure Infections (ABSSSI). US FDA also indicated that this drug should only be used when there is no suitable option left behind because delafloxacin therapy is associated with tendon rupture, neuropathy and impaired cartilage growth.

Acute bacterial skin and skin structure infection (ABSSSI) is also know as soft tissue infection such as infection of connective tissues, mucous membrane and cartilage. Some commonly know soft tissue infections are abscesses, cellulitis, furuncles and impetiginous lesions. It has been observed that  Staphylococcus aureus and Streptococcus pyogenes are main causative agents for number skin soft tissue infections. In most instances, these infection can not cure via traditional antibiotics due to emergence of resistance.

Complicated type of skin infections include ulcers, gangrene and burns. They may become difficult to treat if they spread to internal layers of skin or reach to systemic circulation. Therefore, ration use of antibiotics is very necessary to mitigate the risk of resistance, secondary infection and to avoid further complications as well.

Baxdela/delafloxacin belongs to a pharmacological class termed as fluoroquinolones that inhibit replication of bacterial DNA. It has been observed during clinical trials that delafloxacin is more active than other agents belongs to this group of antibiotics. Main advantage of delafloxacin over other antibiotics of this group is that it readily deposits inside the bacteria and exerts potent bactericidal activity. 


Baxdela/delafloxacin Cost, Side effects, Dosage, Uses

Baxdela/delafloxacin Side effects


According to health authorities this drug exhibit following side effects during clinical trials

  • Nausea
  • Vomiting
  • Rashes
  • Headache
  • Diarrhea
  • Elevated liver enzymes
  • Gastrointestinal discomfort
  • Bloating
  • Hypersensitivity reactions
  • Neuropathy
  • Tendinitis

Baxdela/delafloxacin Uses/Patient Information


US FDA approved this drug for the treatment of acute Bacterial Skin and Skin Structure Infections
(ABSSSI). FDA also indicated that this drug should be used cautiously because it may cause neuropathy, tendinitis or CNS related problems.

Baxdela/delafloxacin Dosage


Baxdela is formulated in two types of dosage forms. One is oral dosage form with potency of 450mg per tablet and second is parenteral dosage form with potency of 300mg per vial. However, standard dosage frequency of Baxdela/delafloxacin is 450mg orally after every 12hrs for 7 to 14 days or 300mg intravenously after every 12hrs for 5-14 days for the treatment of Acute Bacterial Skin and Skin Structure Infections (ABSSSI). In case of renal or hepatic impairment dose titration should be kept in consideration.

Baxdela/delafloxacin Cost/Price


Baxdela is now available at retail outlets with average cost of  2100$ - 2200$ per pack that contains 30 tablets each with 450mg potency. This cost may variate with the passage of time so, make it confirm by visiting your nearby pharmacy before purchasing.

Bevyxxa/betrixaban Cost, Side effects, Dosage, Uses for Venous thromboembolism

Bevyxxa/betrixaban Cost, Side effects, Dosage, Uses for Venous thromboembolism. The FDA granted approval of Bevyxxa to Portola Pharmaceuticals, Inc.

US FDA approved new drug Bevyxxa that contains betrixaban (factor Xa inhibitor) for the prophylactic treatment of venous thromboembolism in those adults who are hospitalized due to acute illness and have risk of thromboembolic phenomenon. FDA also indicated that this drug must not used in patients who are getting epidural anesthesia because it may increase the risk of epidural hematoma during spinal puncture.

venous thromboembolism is very common in bedridden patient especially those who are diabetics. When blood clots dislocate from its primary place and attached to lungs then it is termed as pulmonary embolism. Dislocated clots are very dangerous as they travel inside venous system and can cause blockage of blood circulation towards brain, heart or lungs.

Some risk factors that increase the chances of venous thromboembolism are orthopedic surgeries, older age, pregnancy, trauma, lack of activity for a long time and oral contraceptives. Genetic predisposition and blood disorders are also important in the pathophysiology of venous thromboembolism.

Betrixaban is basically an anticoagulant that inhibits factor Xa directly by binding with it. It has great affinity for factor Xa that's why it has shown promising results in clinical trials. It has also been observed that this drug is very useful for prevention of stroke and atrial fibrillation.



Bevyxxa/betrixaban Cost, Side effects, Dosage, Uses for Venous thromboembolism


Bevyxxa/betrixaban Side effects


According to health authorities drug exhibit following side effects during clinical trials.
  • Increase tendency of bleeding
  • Internal hemorrhage
  • Hypersensitivity reaction
  • Headache
  • Nausea
  • Gastrointestinal discomfort
  • Palpitation
  • Vomit like feeling
  • Abdominal distension

Bevyxxa/betrixaban Uses/Patient Information


US FDA approved this drug for prophylaxis or prevention of venous thromboembolism (VTE) in hospitalized patient due to acute illness because they have higher risk of venous thromboembolism as compared to those who are not bedridden. US FDA also warns that this drug must not be used in those patients who are undergoing for epidural anesthesia due to chances of spinal hematoma.

Bevyxxa/betrixaban Cost and Dosage


Bevyxxa is formulated in the form of oral dosage form (capsules) with potency of 40mg or 80mg per capsule. However, standard dosage frequency of Bevyxxa/betrixaban is 160mg orally for the first dose and 80mg orally for subsequent doses for the prophylaxis of Venous Thromboembolism. Dose titration should be considered in case of renal or hepatic impairment or Concomitant administartion of P-gp inhibitors.

Bevyxxa/betrixaban Cost/Price


Bevyxxa is now available at retail outlets with average cost of 460$ - 490$ per pack that contains 30 capsules each with 40mg strength. This cost may variate with the passage of time so, make it confirm by visiting your nearby pharmacy before purchasing.

Haegarda Cost, Side effects, Dosage, Uses for Hereditary Angioedema

Haegarda Cost, Side effects, Dosage, Uses for Hereditary Angioedema. The FDA granted approval of Haegarda to CSL Behring LLC.

US FDA approved new drug Haegarda for the treatment of rare kind of genetic disorder termed as hereditary angioedema. FDA approved indicated that this drug should be used in adolescent and adults for the treatment of hereditary angioedema. Haegarda is basically C1 esterase inhibitor protein and it is administered via subcutaneous drug delivery system.

Hereditary angioedema is characterized as rare genetic disorder that causes swelling of extremities, face, reproductive organs and internal lining of airway and gastrointestinal tract. Hereditary angioedema may cause episodal attacks of swelling rather than appearing constantly on skin and other areas.

Exact underlying cause is still unknown but many dermatologists believe that mutations inside C1 inhibitor gene is main triggering factor is this whole phenomenon. Up-til now about more than 300 known mutations have identified is this gene. These mutations bring down the level of C1 inhibitor protein that keeps the inflammatory mediators in control like bradykinin, leukotrienes, histamine etc.

In some cases conditions may become worse due narrowing of airways. This is very serious condition and patient should go to hospital for respiratory support because breathing is almost difficult due to narrowing of airways and internal lining of lungs.

Haegarda is basically C1 esterase inhibitor protein derived from human plasma that maintains its level in case of its deficiency due to mutations in C1 gene. This drug is effective routine attacks of angioedema but not for acute attacks of angioedema.

Haegarda Cost, Side effects, Dosage, Uses for Hereditary Angioedema

Haegarda Side effects


According to health authorities following side effects were reported during its clinical trails

  • Anaphylactic reactions (hypersensitivity)
  • Swelling of nasal lining
  • Dizziness
  • Nasopharyngitis
  • Feeling of swollen throat
  • Itchiness at injection site
  • Rashes
  • Redness of skin
  • Mild Fever in some cases

Haegarda Uses or Prescribing Information


US FDA approved  Haegarda for the treatment of hereditary angioedema in adolescent and adults. This drug should only be used in routine attacks not for acute attacks. It is administered via subcutaneous route. Test dose should be to rule out any possibility of allergic reaction.

Haegarda Dosage


Haegarda is formulated as vial of 2000IU or 3000IU in form of lyophilized powder for reconstitution. However, its dosage frequency is 60IU/Kg subcutaneously two times in a week for the Prophylaxis of hereditary angioedema in adults.

Haegarda Cost/Price

Cost on one vial of Haegarda with 2000IU is about 1800$ - 2000$. This cost may variate with the passage of time so, make it confirm by visiting your nearby pharmacy before purchasing.