Kevzara/sarilumab Cost, Side effects, Dosage, Uses for rheumatoid arthritis

Kevzara/sarilumab Cost, Side effects, Dosage, Uses for rheumatoid arthritis. The FDA granted approval of Kevzara to Regeneron Pharmaceutical, Inc., Rensselaer, NY, and Sanofi Winthrop Le Trait, Le Trait, France

US FDA approved new drug Kevzara that contains active pharmaceutical ingredient sarilumab for the treatment of  moderately to severely active rheumatoid arthritis in adult patients who are not responding to disease modifying anti-rheumatic drugs (DMARDs). FDA also indicated that this drug
can be used as single drug therapy or as combination therapy with other anti rheumatic drugs like methotrexate.

Rheumatoid arthritis (RA) is a life-time disease that most commonly affects movable joints of body. Primarily, it is an inflammatory disease manifested as joint swelling, severe pain, stiffness, increase friction and restricted mobility or movement. Major target areas of RA are wrist, hand and ankle joints. Patient may also feel lethargic, reduced energy level, restlessness and fatigue. Symptoms may become severe with passage of time. Treatment of  rheumatoid arthritis mostly consists of disease managements, physiotherapy, exercise and dietary control.

Exact underlying cause of  rheumatoid arthritis is not fully understood but many rheumatologists presume that genetic predisposition, immune system modulation and environmental factors play important role in the pathophysiology of rheumatoid arthritis. Initially, it starts with mild swelling around joints, feeling of joint stiffens right after sleeping and thickening of joint capsule. It is commonly observed that this majorly affects people having age 40 years or more. It has slow onset but longer duration like a chronic disease.

Kevzara/Sarilumab belong to a pharmacological class monoclonal antibody that binds with interleukin-6 receptor and causes inhibition of  IL-6 receptors. Interleukin-6 receptor plays important role in inflammatory response by mediating inflammatory substances such cytokines and
interleukins. Thus, inhibition of interleukin-6 receptor is reduces the process of inflammation of swelling.

Kevzara/sarilumab Cost, Side effects, Dosage, Uses for rheumatoid arthritis


Kevzara/sarilumab Side effects

According to data provided by health authorities this drug exhibit following side effects during clinical trials.

  • Neutopenia
  • Increased liver enzymes (ALT)
  • Reaction at injection site (Erythema)
  • Higher risk of respiratory tract infection
  • Anaphylactic reaction
  • Gastrointestinal perforation
  • Immunosuppression
  • Palpitation 
  • Headache


Kevzara/sarilumab Uses/Patient information

US FDA approved this drug for the treatment of  moderately to severely active rheumatoid arthritis in adult patients who are not responding to disease modifying anti-rheumatic drugs (DMARDs). Data regarding its usage in pregnancy is limited but during initial clinical trails it has been observed that it is actively transported across the placenta during the third trimester of pregnancy.

Kevzara/sarilumab Dosage

Drug is forlumated as 150mg/1.14ml and 200mg/1.14ml as a prefilled syringe. However, standard dosing frequency of this drug is 200mg administer subcutaneously after every two weeks (q2week). Dose titration must be kept in consideration in those patients who have hepatic or renal impairment
or have high ALT or platelets count.

Kevzara/sarilumab Cost/Price

Kevzara is now available in market in two types of strength (potency). Single pack of Kevzara that contains two syringes with potency of 131.6mg/ml costs about 2700$ to 2800$ while Single pack of Kevzara that contains two syringes with potency of 175.4mg/ml costs about 2750$ to 2900$. This price may variate with the passage of time so, make it confirm by visiting your nearby pharmacy before purchasing.

Radicava/edaravone Cost, Side effects, Dosage, Uses for amyotrophic lateral sclerosis (ALS)

Radicava/edaravone Cost, Side effects, Dosage, Uses for amyotrophic lateral sclerosis (ALS). The FDA granted approval of Radicava to Mitsubishi Tanabe Pharma America, Inc.

US FDA approved new drug Radicava that contains active pharmaceutical ingredient edaravone for the treatment of amyotrophic lateral sclerosis (ALS). Radicava/edaravone is categorized as nootropic agent that helps in recovering cerebral damage or degeneration occurs as result of cerebral ischemia, cerebral infarction or any other disorder.

Amyotrophic lateral sclerosis (ALS) also termed as  Lou Gehrig's disease is a rare kind of neuronal problem associated with neuronal death. Neuron is basic unit of nervous system that regulates neuronal transmission required for coordination between body muscles and brain. Amyotrophic lateral sclerosis (ALS) most commonly affects motor neurons that controls body motor functions like driving, walking, speech, breathing etc.

Exact underlying cause is still unknown but many researchers assume that genetic predisposition is key factor in pathogenesis of such disorders. Some other causes that associated with Amyotrophic lateral sclerosis (ALS) are head injury, trauma and branched-chain amino acids enriched diet that induce cellular hyperexcitability. Lesions inside frontotemporal lobes may also be a cause of Amyotrophic lateral sclerosis (ALS).

Initially, it is started as muscular weakness and atropy (decrease in number of cells) . At this time symptoms are very insignificant to feel and patient may overlook these symptoms. when disease progress completely then patine may feel difficulty in walking, speech problems, difficulty with tasks requiring manual dexterity such as buttoning a shirt, writing, or turning a key in a lock may be experienced and muscle spasticity.

Radicava/edaravone Cost, Side effects, Dosage, Uses for amyotrophic lateral sclerosis (ALS)


Radicava/edaravone Side effects


According to data provided by health authorities following side effects were observed during clinical trials

  •     Rash
  •     Hives
  •     Swelling
  •     Shortness of breath
  •     Anaphylaxis
  •     Sodium bisulfite induced allergy
  •     Bruising
  •     Gait disturbance
  •     Nervousness
  •     Loss of appetite
  •     Sleep disturbance

Radicava/edaravone Uses


US FDA approved this drug for the treatment of amyotrophic lateral sclerosis (ALS) to show to slow down functional decline. Radicava/edaravone is free-radical scavenger that is aimed to suppress oxidative degeneration which is a major factor in amyotrophic lateral sclerosis (ALS).

Radicava/edaravone Dosage


This drug is formulated in a single dose polypropylene bag with potency of 30mg/100ml. However, standard dosage frequency of this drug is 60mg as intravenous infusion (IV) over 60 minutes once a day for 14 days followed by a 14-day drug-free period.

Radicava/edaravone Cost/Price

This drug is administered by your healthcare practitioner (HCP), which usually means:
  • It may comes under special items category.
  • You cannot fill this prescription in a regular pharmacy. Your doctor, hospital, or clinic will provide this  medication because of possible complications or other issues.
  • This drug is likely to be covered under your medical benefit if you have insurance.

Tymlos/Abaloparatide Cost, Side effects, Dosage, Uses for postmenopausal osteoporosis

Tymlos/Abaloparatide Cost, Side effects, Dosage, Uses for postmenopausal osteoporosis. US FDA granted approval of Tymlos to Radius Health, Inc.

US FDA approved new medicine Tymlos that contains active pharmaceutical ingredient abaloparatide for the treatment of postmenopausal women with osteoporosis at high risk for fracture. Tymlos/Abaloparatide is parathyroid hormone related protein (PTHrP) and is anabolic agent used to increase bone densification.

Tymlos/Abaloparatide is analogus drug that binds with parathyroid hormone 1 receptor  (PTH1R) which results in activation of Cyclic adenosine monophosphate (cAMP). Cyclic adenosine monophosphate is important compound for intracellular signal transduction in many biological process. This cAMP increase bone densification and mineralization (BMD and BMC) resulting in increase bone strength .

Osteoporosis is worldwide common disease that increase the risk of fractures and bone deformity due to bone demineralization and fragility.  Most commonly affected bones are back bones, forearm bones, hip bone etc. Persistent pain may hinder to carry out routine activities. Osteoporosis symptoms are not obvious initially but later on excessive demineralization may lead to fractures.

Being old, is a major risk factor for osteoporosis. This risk may increase two times in women due to hormonal imbalance after age 40's of 50's. Certain diseases like diabetes, adrenal insufficiency, crohn's disease, coeliac disease, malabsorption disturb calcium phosphorus balance in the body that may lead to osteoporosis if persist for a long term.

TymlosAbaloparatide Cost, Side effects, Dosage, Uses for postmenopausal osteoporosis



Tymlos/Abaloparatide Side effects


According to data provided by health authorities this drug exhibit following side effects during clinical trials
  • Hypercalciuria
  • Dizziness
  • Nausea
  • Headache 
  • Palpitations
  • Fatigue
  • Upper abdominal pain
  • Vertigo
US FDA also instruct for box warning that tymlos/abaloparatide caused a dose-dependent increase in the incidence of osteosarcoma (a malignant bone tumor) in male and female rats; this effect was observed at systemic exposures to abaloparatide ranging from  4-28 times the exposure in humans receiving the 80-mcg dose.


Tymlos/Abaloparatide Uses/Prescribing Information


US FDA approved new medicine Tymlos that contains active pharmaceutical ingredient abaloparatide for the treatment of postmenopausal women with osteoporosis at high risk for fracture. Tymlos/Abaloparatide is parathyroid hormone related protein (PTHrP) and is anabolic agent used to increase bone densification.

Tymlos/Abaloparatide Dosage


This drug is formulated as 80mcg/40mcL (available as a pre-filled pen that delivers 30 daily doses of 80mcg). However, standard dosage frequency is 80mcg subcutaneously once a day. Dose tit-ration should be considered in patient having liver or kidney impairment.

Tymlos/Abaloparatide Cost/Price


Tymlos/Abaloparatide is now available in market. Each pre-filled pen of Tymlos/Abaloparatide has drug voume of 1.56ml. Approximate cost of each pre-filled pen of Tymlos/Abaloparatide is about 1600$ to 1800$. This price may variate with the passage of time so, make it confirm by visiting your nearby pharmacy before purchasing.

Imfinzi/Durvalumab Cost, Side Effects, Dosage, Uses for Urothelial Carcinoma

Imfinzi/Durvalumab Cost, Side Effects, Dosage, Uses for Urothelial Carcinoma. US FDA granted approval of Imfinzi to AstraZeneca UK Limited.

US FDA approved new medicine Imfinzi that contains active pharmaceutical ingredient durvalumab for the treatment of metastatic urothelial carcinoma that is not responding to platinum containing chemotherapeutic drugs. Imfinzi/Durvalumab belongs to a pharmacological class termed as monoclonal antibodies that targtet programmed death ligand-1 (PD-L1).

Moreover, US FDA approved this indication under accelerated approval pathway based on tumor response rate and duration of response. Continued approval for this indication may be contingent upon verification and description of clinical benefit in confirmatory trials.

Urothelial carcinoma (Transitional cell carcinoma) is type of carcinoma that affects urinary tract most likely ureter, urethra and urachus. It is highly progressive form of malignant tumor that arises from transitional epithelium (Urothelium). This type of tumor readily spread to nearby tissues and is difficult to eradicate completely. Urothelial carcinoma has high recurrence rate even after surgical resection. Symptoms of urothelial carcinoma are not obvious and vary from patient to patient. However, some pre-defined symptoms are small amount of blood in urine, consistent pain in back due to tumor pressure, weakness, painful micturition , unexplained weight loss.

Exact underlying mechanism is not fully understood but many scientist and researchers presumed that genetic predisposition, smoking, being old age, exposures to chemicals in chemical processing industries like paints, petroleum products, toxic compounds like aniline double the risk of urothelial carcinoma.In some, patients it is also associated with prostate gland. Certain drugs like cyclophosphamide and chronic bladder infections are also known to cause urothelial carcinoma.


ImfinziDurvalumab Cost, Side Effects, Dosage, Uses for Urothelial Carcinoma



Imfinzi/Durvalumab Side effects


According to data provided by health authorities this drug showed following side effects during clinical trials


  • Fatigue
  • Headache
  • Muscular pain
  • Loss of appetite 
  • Drug induced colitits 
  • Increase risk of infection
  • Edema
  • Colitis
  • Hypersensitivity reactions
  • Rashes
  • Infusion related reactions
  • Mild fever


Imfinzi/Durvalumab Uses/Patient Information


US FDA approved Imfinzi/Durvalumab for the treatment of  advance progressive urothelial carcinoma that is not responding to other chemotherapeutic drugs like platinum containing drugs. This drug can also be used in combination with other chemotherapeutic agents to get more efficacious results. Moreover, initial studies conducted by health authorities also suggest that imfinzi/durvalumab may pose risk to fetal development so it should be avoided in pregnancy.

Imfinzi/Durvalumab Dosage


Imfinzi is formulated as 120mg/2.4mL (50mg/mL) single-dose vial and 500mg/10mL (50mg/mL) single-dose vial. However, standard dosage frequency of imfinzi is 10mg/Kg intravenously via infusion over 1 hr. In case of toxicity or severe adverse effects like pneumonitis, hepatitis or colitis withhold or discontinue drug to manage such adverse effects.

Imfinzi/Durvalumab Cost/Price


It is assuming that monthly cost of Imfinzi would be around $13,000, a spokeswoman said in a statement, compared with its rivals' $12,500.