Xadago/safinamide Cost, Side effects, Dosage, Uses for Parkinson’s disease

Xadago/safinamide Cost, Side effects, Dosage, Uses for Parkinson’s disease. The FDA granted approval of Xadago to Newron Pharmaceuticals.

US FDA approved a new drug that contains active ingredient safinamide as an adjuvant therapy for the treatment of  Parkinson disease. According to FDA this drug should be used as add on therapy when other Parkinson medications such levodopa or carbidopa does not provide adequate response or symptoms of Parkinson may get worse (off episodes).

Parkinson disease (PD) is a characterized as degenerative disorders that affects motor functions as well as activities related to central nervous system. Disease onset is slow but it remains lifetime and symptoms of parkinson disease may become severe with the passage of time. In advance stages, this disease may lead to further irreversible changes like dementia. Most common manifestations of this disease are mood changes, cognitive impairment, speech difficulty, tremors, rigidity, difficulty in movements etc. The exact underlying cause this disease is still unclear but many scientist
believed that genetic predisposition and certain environment factors play important in role in pathogenesis of Parkinson disease.

Xadago has dual mechanism of action based to increase concentration of dopamine on pre-synaptic cleft by reversible  inhibition of MAO-B and of dopamine uptake and creases the induction of glutamate release. End point of all Parkinson based medications is inducing the release of dopamine on pre-synaptic cleft, reducing the degradation of dopamine neurotransmitter or inhibition of dopamine re-uptake.


Xadagosafinamide Cost, Side effects, Dosage, Uses for Parkinson’s disease


Xadago/safinamide Side effects


According to data obtained from clinical trials of Xadago/safinamide side effects are categorized as common side effects and less common side effects.

Common Side effects

  • Nausea 
  • Vomiting
  • Difficulty in sleeping
  • Insomnia 
  • Uncontrolled movements

Less common Side effects

  • Hyperprexia
  • hypertension
  • serotonin syndrome
  • agitation
  • retinal problems

Xadago/safinamide Uses

FDA approved Xadago for the treatment of Parkinson disease in patients who experience "off episode" e.g symptoms are getting worse even after using Parkinson base medications like dopa drugs. In that case Xadago is helpful and patient can take this drug as add on therapy.

Xadago/safinamide Dosage

Safinamide comes in two strength 50mg and 100mg in the form of tablet (oral dosage form). However, it's standard dosage frequency is 50mg tablet orally once in a day for 2 weeks and then dosage may increase up-to 100mg orally once a day. In case of renal or liver impairment dose titration may required.

Xadago/safinamide Cost/Price

Xadago is now available in market with two potencies 50mg and 100mg. Cost of single pack of Xadago 50mg tablets (30's) is approximately 690$ to 750$ while cost of single pack of Xadago 100mg tablets (30's) is approximately 700$ to 800$. This price may variate with the passage of time so, make it confirm by visiting your nearby pharmacy before purchasing.

Share this

Related Posts

Previous
Next Post »

Leave a reply