Siliq/brodalumab Cost, Side effects, Dosage, Uses for Psoriasis

Read about Siliq/brodalumab Cost, Side effects, Dosage, Uses for Psoriasis. Siliq is marketed by Bridgewater, New Jersey-based Valeant Pharmaceuticals.

U.S FDA approved new medicine siliq that contains active drug brodalumab for the treatment of psoriasis in adults. Psoriasis is a common auto-immune disorder in among all populations. Psoriasis might be of different types like plaque psoriasis, guttate psoriasis, erythrodermic psoriasis, inverse psoriasis and postular psoriasis. FDA approved Siliq for moderate to severe plaque psoriasis in adults.

Plaque psoriasis is basically a skin disorder that intense irritation and itching on skin and leaves the skin scaly or flaky along with reddish color appearance of skin. This condition may occur without regard to gender, age or ethnicity. However, it is commonly observed that people who have family history of plaque psoriasis or other are more prone to get involved in such disorder.

Siliq/brodalumab belongs to a group termed as monoclonal antibody. Basic mechanism by which brodalumab targets plaque psoriasis is that it binds to receptor interleukin-17 that generates inflammatory mediators to aggravate plaque psoriasis. Interleukin-17 does not activate after binding to brodalumab making it unable to release inflammatory mediators to make condition worse.

Siliq/brodalumab Cost, Side effects, Dosage, Uses for Psoriasis


Siliq/brodalumab  Side effects

During clinical trials drug exhibit some side effects or adverse effects experience by adult participants. These side effects were moderate to severe e.g
  • Fatigue
  • Diarrhea
  • Joint pain (arthralgia)
  • Headache
  • Injection site reactions
  • Influenza
  • low white blood cell count (neutropenia)
  • Fungal (tinea) infections
  • Throat pain (oropharyngeal pain)
  • Nausea, muscle pain (myalgia)   
  • Suicidal tendency 

Siliq/brodalumab Uses 

U.S FDA approved brodalumab for the treatment of  moderate to severe plaque psoriasis in adults. However, you healthcare provider (HCP) may recommend you a combined therapy in order to make treatment successful and better control over disease management.

Siliq/brodalumab Dosage

This drug will be available in the form of subcutaneous injection with potency of 210mg/1.5ml (single dose prefilled syringe). Standard dosage frequency of this drug is 210mg subcutaneously (SC) once in a week consecutively for 3 weeks and then 210mg subcutaneously (SC) after every two weeks.

Siliq/brodalumab Cost/Price

Siliq is now available in market. Average cost of 1 pack of siliq is about 2900$ to 3050$. Each pack contains 2 prefilled syringes of of Siliq of 210mg/1.5ml. This price may variate with the passage of time so, make it confirm by visiting your nearby pharmacy before purchasing.

Emflaza/deflazacort Cost, Side effects, Dosage, Uses for Duchenne muscular dystrophy (DMD)

Read about Emflaza/deflazacort Cost, Side effects, Dosage, Uses for Duchenne muscular dystrophy (DMD). Emflaza is marketed by Marathon Pharmaceuticals of Northbrook, Illinois.

US FDA approved new medicine Emflaza that contains active ingredient deflazacort in oral dosage form for the treatment of Duchenne muscular dystrophy (DMD). Emflaza belongs to a therapeutic class termed as corticosteroids. Emflaza is basically a prodrug which is converted in active metabolite after its metabolism. All corticosteroids works by reducing swelling, inflammation and settling down the exaggerated immune response.

Duchenne muscular dystrophy (DMD) is a rare kind of genetic disorder that causes degeneration of muscles. Due to some genetic defect a protein termed as dystrophin does not produce in the body. The basic physiological role of dystrophin is keeping body muscles intact and healthy.

But dystrophin absence in Duchenne muscular dystrophy (DMD) makes muscle more vulnerable to degradation, degeneration and physical deterioration. Symptoms may first appear in the age of 5 years or earlier. After the onset of disease symptoms may get worst with the passage of time.

In extreme cases duchenne muscular dystrophy (DMD) may cause walking disability, cardiovascular or respiratory muscles collapse. These disabilities may appear at any time without regard to age. According to statistics this disease is more common in boys as compared to girls.

Emflaza/deflazacort Cost, Side effects, Dosage, Uses for Duchenne muscular dystrophy (DMD)

Emflaza/deflazacort Side effects

According to clinical data provided by health authorities Emflaza demonstarted a significant results over placebo. However, side effects were similar to other corticosteroids therapy. Most commonly observed side effects were as follows
  • Weight gain
  • Hair growth (hirsutism)
  • Central obesity
  • Facial puffiness (Cushingoid appearance)
  • Upper respiratory tract infection
  • Increased appetite
  • Urinary frequency
  • Cough 

Emflaza/deflazacort Uses/Prescribing information 

Though, number of corticosteroids are being used to muscular disorders like duchenne muscular dystrophy (DMD) But US FDA specifically approved Emflaza in oral dosage form for the treatment of  duchenne muscular dystrophy (DMD) in patients age 5 years and older.

 

Emflaza/deflazacort Dosage

According to medical literature provided this drug will come in following potencies 6mg, 18mg, 30mg and 36mg. Oral suspension of this drug will come up with potency of 22.75mg/mL. Drug will be administered according to body weight by following the standard of 0.9 mg/kg/day orally.

 

Emflaza/deflazacort Cost/Price 

Emflaza is now available at retail outlets for end consumers. At this time, Emflaza with potency of 6mg is only available in market in tablet form. Single pack of Emflaza has 30 tablets each tablet contains 6mg of deflazacort. Cost of single pack (30's) of Emflaza is between 7500$ to 8000$. This price may variate with the passage of time so, make it confirm by visiting your nearby pharmacy before purchasing.