Amjevita/adalimumab-atto Cost, Side effects, Dosage, Uses for multiple inflammatory diseases

Read about Amjevita/adalimumab-atto Cost, Side effects, Dosage, Uses for multiple inflammatory diseases. Amjevita is manufactured by Amgen, Inc., of Thousand Oaks, California.

The U.S. Food and Drug Administration has approved a new biosimilar drug Amjevita that contains adalimumab-atto as an active pharmaceutical ingredient.Amjevita is a biosimilar to previously approved drug Humira manufactured by AbbVie Inc. of North Chicago, Illinois.

   
Amjevita/adalimumab-atto basic mechanism is inhibition or suppression tumor necrosis factor alpha (TNFa) which is main culprit for inflammatory response in inflammatory diseases (auto-immune) like rheumatoid arthritis, psoriatric arthritis, ankylosing spondylitis etc.It was observed during clinical trial that administration of adalimumab and methotrexate (MTX) provide synergistic effect and doubles the therapeutic efficacy of methotrexate. Apart from these indications Amjevita/adalimumab-atto can also be used in a patho-physiological condition where suppression of immune system is required. This drug is administered through subcutaneous route (sc).

Multiple inflammatory diseases is a group of disorders that belongs to malfunctioning of immune system. Most common examples of these diseases are rheumatoid arthritis, ulcerative colitis, crohn's disease, hidradenitis suppurativa, juvenile idiopathic arthritis. All kinds of auto-immune disorders are treated and managed by following combination of therapy like DMARD's, Immunosuppressants, Steroidal drugs, etc.

Amjevita/adalimumab-atto Cost, Side effects, Dosage, Uses for multiple inflammatory diseases

 Amjevita/adalimumab-atto Side effects


Amjevita is a biosimilar of Humira  so, both have almost same kind of indications and side effects. These side effects can be categorized into moderate to severe.

Moderate Side effects 

  • Generalized weakness
  • feeling of numbness
  • Body pain
  • Shortness of breath
  • vision problems
  • skin rashes
  • swelling on body

Severe Side effects

Severe kind of side effects associated with this drugs are increase risk of

  • Infections like respiratory infection, liver and kidney infection.
  • Malignancy  

Amjevita/adalimumab-atto Uses

U.S FDA approved this drug for multiple inflammatory diseases which is a class of auto-immune disorders. Auto-immune disorders are of many types like rheumatoid arthritis, ulcerative colitis, crohn's disease, hidradenitis suppurativa, juvenile idiopathic arthritis. This drug can also be used in combination with other drugs like methotrexate.

Amjevita/adalimumab-atto Dosage

This drug is formulated as pre-filled syringe with potency of 40mg/0.8ml. Standard dosage of amevita/adalimumab  is 40mg after every two weeks. It is administered subcutaneously and dose may be adjusted depending upon the severity of disease and patient condition. During this therapy your health care provider may also prescribe you some other DMARD's like methotrexate to make the treatment more effective.

Amjevita/adalimumab-atto Cost/Price 

According to market survey this drug is currently not available at retail pharmacies because it is recently approved by FDA and is under manufacturing process. Once, it will be available at retail outlets we will let you know about the unit cost of drug and its dosage frequency.

Exondys 51/eteplirsen Cost, side effects, Mechanism, Dosage for Duchenne muscular dystrophy (DMD)

Read all about Exondys 51/eteplirsen Cost, side effects, Uses, Dosage for Duchenne muscular dystrophy (DMD). Exondys 51 is made by Sarepta Therapeutics of Cambridge, Massachusetts.

US FDA approved a new novel drug Exondys 51 for the treatment of Duchenne muscular dystrophy (DMD). This drug contains eteplirsen as an active ingredient. Exondys 51/eteplirsen specifically targets mutations that occurs in DMD gene.This drug has been approved only for the treatment and management of Duchenne muscular dystrophy (DMD) but it does not mean that it cures it forever.

Duchenne muscular dystrophy (DMD) is rare kind of disorder but it is very devastating degenerative disease. In this disease some mutational changes occur in DMD gene which leads to alteration in DMD RNA transcription process. This altered DMD RNA becomes non-functional or in-active and does not bind or recognize dystrophin protein. This is the main root cause of Duchenne muscular dystrophy (DMD).

Exondys 51/eteplirsen Mechanism of Action or Pharmacology


Exondys 51/eteplirsen is  morpholino antisense oligomer that causes cleavage of exon 51 (part of a gene that will encode a part of the final mature RNA) during pre mRNA splicing phase of dystrophin protein.This process will generate a functional but modified form of dystrophin protein (skipping exon therapeutically) that can reinstate the binding process that was impaired due to genetic mutations.

The whole process initiated by this drug does not cure this problem but reduce the severity, progression and degeneration. Majority of patients suffering from DMD have this kind of mutation and can be treated effectively with the help of this therapeutic drug Exondys 51/eteplirsen.

Exondys 51/eteplirsen Cost, side effects, Mechanism, Dosage for Duchenne muscular dystrophy (DMD)


Exondys 51/eteplirsen Side effects

According to clinical trials this drug exhibited some minor side effects but no life threatening side effect was reported at that time. These minor side effects were

  • Balance disorder
  • Nausea
  • Vomiting
  • Headache
  • Dizziness
  • palpitation

This drug is administered in form of infusion through intra-venous route only.

Exondys 51/eteplirsen Dosage

This drug is formulated as a single dose vial with potency of 50mg/ml. In adult DMD patients  its standard dosage is 30mg/Kg through intravenous route once in a week. Dose titration may be considered depending upon the patient condition and severity of disease. 

Exondys 51/eteplirsen Cost/Price

This drug is administered by your healthcare practitioner (HCP), which usually means:
  • It may comes under special items category.
  • You cannot fill this prescription in a regular pharmacy. Your doctor, hospital, or clinic will provide this  medication because of possible complications or other issues.
  • This drug is likely to be covered under your medical benefit if you have insurance.