Adlyxin/lixisenatide Cost, Side effects, Dosage, Uses for Type 2 Diabetes

Adlyxin/lixisenatide Cost, Side effects, Dosage, Uses for Type 2 Diabetes. Adlyxin is manufactured by Sanofi-Aventis U.S. LLC, of Bridgewater, New Jersey.

Adlyxin with an active ingredient lixisenatide is the new drug approved by U.S. Food and Drug Administration on July 28, 2016. This drug is approved in parentral dosage form. It's dosage frequency is once a day and injected through subcutaneous route. Adlyxin/lixisenatide belongs to a class of drug called as a glucagon-like peptide-1 (GLP-1) receptor agonist. GLP-1 is hormone that helps in the regulation of blood sugar control.

Type 2 diabetes is a common problem in US population. In type 2 diabetes, insulin produces at normal level but insulin sensing receptors present in liver, kidney and other organ tissues become desensitize. This desensitization leads to improper or poor attachment of insulin at insulin bind receptors. Ultimately, patient loses his control over blood sugar and becomes diabetic.

Adlyxin is aimed to improve blood  sugar level along with exercise and dietary control because no single pill can efficiently control blood sugar control without taking further measures. Type 2 diabetes is a kind of disease that can be managed by taking medications along with life style modifications.

During clinical trails Adlyxin safety profile was quite satisfactory. Adlyxin is quite safe for patient having types 2 diabetes along with atheroseclerosis ( stenosis of arteries).  Adlyxin helps to improve blood sugar level with no harm to cardiac issues like angina, atrial fibrillation, tachycardia, thromboembolic phenomenon and atherosclerosis.

Adlyxin/lixisenatide Cost, Side effects, Dosage, Uses for Type 2 Diabetes

Adlyxin/lixisenatide Side effects

Adlyxin was tested for possible side effects during clinical trials. These side effects were mild moderate.
  • Nausea
  • Vomiting
  • Headache
  • Diarrhea
  • Dizziness
  • Hypersensitivity
  • Anaphylaxis
  • Asthenia
  • Muscle Weakness
  • Mild Fever
  • Rash at injection site
  • Loss of appetite 
 According to data received from clinical trials, Adlyxin does not have life threatening or lethal side effects.

 Adlyxin/lixisenatide Uses/Prescribing Information 

US FDA approved Adlyxin to control blood sugar level in type 2 diabetes. Adlyxin gives better control over blood sugar level if it used with other diabetes medications following life style modifications and dietary restrictions.

However, this drug was also tested as standalone therapy during clinical trials in which it is showed promising results. Adlyxin should not be used to treat people with type 1 diabetes or patients with increased ketones in their blood or urine (diabetic ketoacidosis).

 Adlyxin/lixisenatide Dosage

Adlyxin/lixisenatide pack contains two types of pen. One is green pen and other is bugendy pen. Green pen is 3mL prefilled pen and each ml contains 50mcg/ml dose. It is used as starter dose. It provides 14 dose of 10mcg/dose. Start with green pen and inject subcutaneously 10mcg/day for 14 days.

Now, on day 15 use burgundy pen as maintenance dose. Burgundy pen is also 3mL prefilled pen and each ml contains 100mcg/ml dose. It is used as maintenance dose. It provides 14 doses of 20mcg/dose. Inject subcutaneously 20mcg/day for 14 days.

 Adlyxin/lixisenatide Cost/Price 

This drug is now available at retail outlets with an average cost of 570$ to 620$ per pack. One pack of adlyxin conatins 2 prefilled syringes each of 3ml. This price may variate with the passage of time so, please make it confirm before purchasing.

Xiidra/lifitegrast Cost, Side effects, Dosage, Uses for Dry eye

Xiidra/lifitegrast Cost, Side effects, Dosage, Uses for Dry eye. Xiidra is manufactured by Shire US Inc., of Lexington, Massachusetts.

FDA has approved a new drug having active ingredient lifitegrast with brand name of Xiidra for the treatment of dry eye disease. This drug belongs to class termed as lymphocyte function-associated antigen 1 (LFA-1) antagonist. This is first kind of drug of its class approved for the treatment of dry eye disease. This drug is presented to FDA in the form of ophthalmic solution and marked as prescription only medicine.

Dryness of eyes is a common problem in elder people due to decrease activity of tears gland. Dryness of eye itself does cause any harm or damage to eye but it increases the risk of eye ulcer, corneal injury, difficulty in blinking, vision problem etc. About 5% of individuals having age 30 to 40 years have problem of dryness of eyes while people with age more than 65 years have 10% occurrence rate.

Most common reasons of eye dryness is inadequate production of tears or low consistency of ophthalmic fluid. These problem may arise due to extreme weather conditions like extreme hot or cold weather or too much air pressure.

About 1100 individuals were selected to assess the clinical efficacy and safety profile of Xiidra/lifitegrast. It shows satisfactory results in four randomized controlled clinical trials. During these clinical trials patients received lifitegrast eyedrops or placebo eyedrops twice daily 12 hours apart for 12 weeks.

 Xiidra/lifitegrast Cost, Side effects, Dosage, Uses for Dry eye

Xiidra/lifitegrast Side Effects

During clinical trials most common side effects observed were mild to moderate but there was no evidence of serious kind of side effects. Some common side effects were

  • Eye irritation
  • Blurred vision
  • Discomfort
  • Dysgeusia (Feeling unusual taste)
  • Headache
  • Burning sensation

Xiidra/lifitegrast Uses or Prescribing Information

FDA approved Xiidra/lifitegrast for treatment of dryness of eye in ophthalmic dosage form. Tin his drug is marked as prescription only medicine so you need a valid prescription in order to get this medicine.

Xiidra/lifitegrast Cost/Price

This drug was presented to FDA in ophthalmic dosage form with potency of  5% ophthalmic solution. Xiidra is now available in market with pack size of 60's. According to market survey initial cost or price of one box is about 400$ - 500$ that contains 60 ampules. This price may variate with the passage of time so, make it confirm by visiting your nearby pharmacy before purchasing.

Xiidra/lifitegrast Dosage

In adults, usual dosage frequency of xiidra is one drop into each eye after every 12hrs for 3-5 days depending upon the severity of disease. In children, xiidra safety profile has not yet evaluated.