Spinraza/nusinersen Cost, Side effects, Dosage, Uses for spinal muscular atrophy

Read about Spinraza/nusinersen Cost, Side effects, Dosage, Uses for spinal muscular atrophy. Spinraza is marketed by Biogen of Cambridge, Massachusetts and was developed by Ionis Pharmaceuticals of Carlsbad, California.

U.S FDA approved new medicine spinraza that contains active ingredient nusinersen  for the treatment of rare muscular disorder known as spinal muscular atrophy (SMA). FDA approves this drug in parenteral dosage form and a medical specialist is required to inject this drug because it is administered  into the fluid surrounding the spinal cord.

Spinal muscular atrophy is a rare kind of genetic disorder. Motor neurons are important to control motor functions of body like moving, driving, various muscular movements etc. Increase in number of dead motor neurons makes the co-ordination weak between brain and skeletal muscles. This will ultimately leads to the development of SMA (spinal muscular atrophy). However, certain risk factors that play important role in the development of SMA (spinal muscular atrophy) are genetic predisposition, age factor, auto-immune disease etc.

This drug belongs to antisense oligonucleotide family and can be used in all types of spinal muscular atrophy. It is injected through intrathecal route so, much care is required during its administration in order to avoid nerve damage. This drug has been received orphan drug designation which provides incentives to assist and encourage the development of drugs for rare diseases.


Spinraza/nusinersen Cost, Side effects, Dosage, Uses for spinal muscular atrophy

Spinraza/nusinersen Side effects

During initial clinical trials drug shows following side effects
  • Thromobocytopenia (low platelets count) 
  • Anemia (low RBC's count)
  • Increased risk of respiratory tract infection
  • Kidney damage (nephrotoxicity)
  • Brain damage (neurotoxicity)
  • Constipation
  • Headache
  • Dizziness
  • Hypersensitivity reactions
  • Skin rashes
  • Painful administration

Spinraza/nusinersen Uses or Prescribing information

U.S FDA approved this drug for all kinds of spinal muscular atrophy (SMA). This drug should be used once every 4 months after loading dose administration via intrathecal route. Care should be taken while injecting this drug to avoid any nerve damage.

Spinraza/nusinersen Dosage

This drug is manufacturing as single dose vial with potency of 12mg/5mL. Dosage of spinraza is diving into two phases.

Loading Dose: It includes 4 doses each of 12mg intrathecally. Administer first 3 doses at 14-day intervals and then administer 4th dose 30 days after the last (3rd) dose.

Maintainance Dose: It includes dose of 12 mg intrathecally per administration after every 4 months.

Spinraza/nusinersen Cost/Price

This drug is administered by your healthcare practitioner (HCP), which usually means:
  • It may comes under special items category.
  • You cannot fill this prescription in a regular pharmacy. Your doctor, hospital, or clinic will provide this  medication because of possible complications or other issues.
  • This drug is likely to be covered under your medical benefit if you have insurance.

Rubraca/rucaparib Cost, Side effects, Dosage, Uses for advanced ovarian cancer

Read about Rubraca/rucaparib Cost, Side effects, Dosage, Uses for advanced ovarian cancer. Rubraca is marketed by Clovis Oncology, Inc. based in Boulder, Colorado. 

U.S FDA assigned accelerated approval pathway to new medicine Rubraca that contains active ingredient rucaparib for the treatment of various types of ovarian cancer. According to FDA guidelines this drug should be used in progressive or advance type of ovarian cancer.

According to statistical data ovarian cancer is one of most leading type of cancer in women with high mortality rate. Ovarian cancer has multiple types some of which are idiopathic while others are due to mutation in specific genes e.g BRCA gene. Statistics shows that in United states approximately 20,000 to 22,000 women diagnosed with ovarian cancer annually and about 60 to 70 percent of these women die due to ovarian cancer. In united states most majority of women have ovarian cancer due to mutation of BRCA gene.

Rubraca/rucaparib achieved accelerated approval pathway due to its targeted action. Normally BRCA genes involves in the development of DNA but due to mutation in BRCA genes they produce altered DNA and give rise to tumor cells. rubraca/rucaparib works by blocking the enzyme (polymerase) that is necessary for DNA replication. This blockade will restrict the process of DNA replication or repairing, leading to cell death and possibly a slow-down or stoppage of tumor growth.

Rubraca/rucaparib Cost, Side effects, Dosage, Uses for advanced ovarian cancer


Rubraca/rucaparib Side effects


During clinical trails following side effects were reported in patient who were receiving this medicine

  • Low platelets count
  • Decrease in red blood cells
  • Difficulty in breathing
  • Changes in taste sensation
  • Fatigue
  • Nausea
  • Vomiting
  • Skin rashes

Rubraca/rucaparib Uses or Prescribing Information


U.S FDA granted its use in women who have advance ovarian cancer and one or more of the mutations of BRCA genes are detected, the patient may be eligible for treatment with Rubraca. However drug should be used with caution in patients who have bone marrow problem because this drug may cause myelodysplastic syndrome in those patients. This drug is not safe for fetus development so, always consult with your health care provide (hcp) before starting any medicine.

Rubraca/rucaparib Dosage


This drug is manufacturing in the form of tablets (Oral dosage form) with potency of 200mg and 300mg. Standard dosage frequency of Rubraca/rucaparib is 300mg tablet twice a day (BID) daily until disease progression reduced to maximum level. Dose adjustment may be required in case of severe side effects, hepatic or renal impairment. Safety profile of this drug has not yet evaluated in children.

Rubraca/rucaparib Cost/Price 

This drug is now available in the market with an average cost of 3900$ to 3700$ per pack. There two potencies of rubraca 200mg and 300mg available in the market. Both have same pack size (30's). This price may variate with the passage of time so, make it confirm by visiting your nearby pharmacy before purchasing.

Eucrisa/crisaborole Cost, Side effects, Dosage, Uses for Eczema

Read about Eucrisa/crisaborole Cost, Side effects, Dosage, Uses for Eczema. Eucrisa is manufactured by Palo Alto, California-based Anacor Pharmaceuticals, Inc.

U.S FDA approved new drug Eucrisa that contains crisaborole as topical dosage form  (ointment) for the treatment of eczema ( atopic dermatitis) in patients having age 2 years or more. Eczema. Eczema or atopic dermatitis is a common skin disorder among all populations. It is intense form of skin disorder with an inflammatory response that requires long-term management or sometimes life time management in advance stages.

Exact underlying cause of eczema is not fully understood that triggers inflammatory response. It is proposed that genetic predisposition, environmental factors and immunogenic response play key role in the parthenogenesis of eczema. Most common symptoms of eczema include dry and red scaly appearance of affected area of skin with intense itching. Scratching may cause skin thickness along with swelling that prolongs the duration of therapy.

Main mechanism of Eucrisa/crisaborole is inhibition of  phosphodiesterase-4 that causes inflammation by triggering the release of certain inflammatory mediators like interleukin-12(IL-12), bradykinins, cytokinins and tumor necrosis factor (TNFα). As name indicates that it contains boron that penetrates readily and rapidly into skin is essential for its binding activity.

Eucrisa/crisaborole Cost, Side effects, Dosage, Uses for Eczema

Eucrisa/crisaborole Side effects

According to clinical data provided by health authorities following side effects were documented during clinical trials

  • Hypersensitivity reactions
  • Burning sensation
  • Sting like feeling
  • Mild pain during application

Eucrisa/crisaborole Uses or Prescribing information

U.S FDA approved only topical form of Eucrisa/crisaborole for the treatment eczema ( atopic dermatitis). Clinical data suggests that it should be applied two times a day to get better results. Eucrisa/crisaborole should not be used in patients having age less than 2 years.

Eucrisa/crisaborole Dosage

Eucrisa/crisaborole is manufacturing in the form of ointment with potency of 2%. Normally it should be applied in the form of thin layer topically to affected area twice a day. It should be used in case of mild to moderate kind of atopic dermatitis. It should not be used in children having age less than 2 years.

Eucrisa/crisaborole Cost/Price

Eucrisa is now avaiable in the market in two pack size 60g and 100g. Average cost of 1 tube (60g) of eucrisa with 2% potency ranges between 500$ - 800$. This price may variate with the passage of time so, make it confirm by visiting your nearby pharmacy before purchasing.

Intrarosa/prasterone Cost, Side effects, Dosage, Uses for intercourse Pain in Women

Read about Intrarosa/prasterone Cost, Side effects, Dosage, Uses for intercourse Pain in Women. Intrarosa is marketed by Quebec-based Endoceutics Inc.

U.S. FDA approved a new product Intrarosa that contains active ingredient prasterone for the treatment of pain in postmenopausal women during sexual intercourse. This pain intensity might be moderate to severe and condition is known as dyspareunia. Intrarosa is first kind of this category approved by FDA. Prosterone is basically a steroidal hormone that produces naturally inside body ( endogenous Production). It is also know as Dehydroepiandrosterone (DHEA) and circulates in human body in large amounts. Prosterone plays many physiological role in the body like biosynthesis of sex hormones like estrogens and androgens.

Postmenopuasal problems are very common in women like flushing, mood swings, metabolic changes in the body and osteoporosis. According to research major underlying cause of intense pain during sexual intercourse in postmenopausal women is atrophy of internal membrane of vulva and vagina. It is proposed that this atrophy is triggered due to low levels of estrogen circulating in the body and vaginal tissues for a long time and condition is known as vulvar and vaginal atrophy (VVA).

Basic mechanism of Intrarosa (prasterone) is that it decreases the adrenal insufficiency in women but still exact pathway by which it works is not fully understood due to inadequate clinical data. According to FDA its efficacy was established after 12 week clinical trials and women who were taking intrarosa during these trials experienced remarkable decrease in the severity of pain.


Intrarosa/prasterone Side effects 

According to data obtained from clinical trials all side effects were minor to moderate. During these clinical trials no life threatening or lethal side effect was reported. Detail of these side effects is as follows

Minor Side effects

  • Headache
  • Irritation during insertion
  • Sense of discomfort in lower abdominal

Moderate Side effects

  • Vaginal Discharge
  • Abnormal Pap smear
  • Vaginal pain
  • Vaginal odor

Intrarosa/prasterone Uses or Prescribing Information

Though, prasterone is available in many dietary supplements but FDA approved only vaginal pessaries of prasterone to decrease the intensity of pain during intercourse in postmenopausal women. According to clinical trials intrarosa shows its therapeutic effect when used for specified period of time. Short term usage for few days does not produce significant effect.

Intrarosa/prasterone Dosage

Intrarosa is manufacturing in the form of vaginal insert tab or pessary. Each tab or pessary contains 6.5mg of prasterone for the treatment of moderate to severe dyspareunia caused by postmenopausal vulvar/vaginal atrophy. Standard dosage frequency of intrarosa in women is 1 vaginal insert daily at bedtime with the help of applicator.

Intrarosa/prasterone Cost/Price

Intrarosa is now available in market with an approximate cost of 13$ to 19$ for 1 vaginal insert ( pessary) that contains 6.5mg of prasterone. This price may variate with the passage of time so, make it confirm by visiting your nearby pharmacy before purchasing.

Lartruvo/olaratumab Cost, Side effects, Dosage, Uses for soft tissue sarcoma (STS)

Read all about Lartruvo/olaratumab Cost, Side effects, Dosage, Uses for soft tissue sarcoma (STS). Lartruvo is marketed by Eli Lilly and Company based in Indianapolis, Indiana.


FDA has approved a new drug Lartruvo for soft tissue sarcoma. This drugs contains active ingredient olaratumab which monoclonal antibody and extracted from human origin.Monoclonal antibodies are derived from cells of immune system and have high affinity for binding to specific site. Monoclonal antibodies are commonly usedin chemotherapy to target specific site and minimize the chances of toxicity.

FDA recommended the usage of newly approved drug Lartruvo (olaratumab) in combination with doxorubicin to make soft tissue sarcoma treatment more effective.According to guidelines provided by FDA this drug along with doxorubicin should only be used in those patients who are not recovering after radiation or surgery.

Soft tissue sarcoma (STC) is a kind of tumor that originates from connective tissues. There are number of underlying factors that contribute towards development of soft tissue sarcoma. For example excessive exposure to toxic substances in chemical industries, severe viral infection, genetic predisposition, environmental exposure or pollution etc.

Basic mechanism of Lartruvo (olaratumab) is that it blocks platelet derived growth factor (PDGF) receptor alpha that increases the growth of soft tissue sarcoma. PDGF is basically a protein that contributes in tumor growth. Latruvo decreases the progression of this disease by blocking these proteins.


Lartruvo/olaratumab Cost, Side effects, Dosage, Uses for soft tissue sarcoma (STS)


Lartruvo/olaratumab Side effects

According to data received from clinical trails following side effects were observed initially,

  • Neuropathy or Nerve damage
  • Baldness
  • Loss of appetite
  • Low white blood cells count (Neutropenia)
  • Fetal abnormalities
  • Reactions during infusion
  • Blood pressure fluctuations
  • Asthenia
  • Swelling of mucous membranes
  • Headache
  • Musculoskeletal pain
  • Nausea
  • Vomiting
  • Abdominal discomfort

Lartruvo/olaratumab prescribing information/uses

According to data provided by U.S FDA this drug is reserved for those patients who are not responding to radiations or surgery. FDA also recommended that this drug should be used in combination with doxorubicin to make the treatment more targeted and effective.

Lartruvo/olaratumab Dosage

This drug is formulated as a 50ml vial for intravenous use with potency of 10mg/ml. Standard dosage of lartruvo for the treatment of soft tissue sarcoma is 15mg/Kg intravenously at rate of 1-8hrs.Dose adjustment can be done depending upon the patient condition and disease progression.

Lartruvo/olaratumab Cost/Price

This drug is administered by your healthcare practitioner (HCP), which usually means:
  • It may comes under special items category.
  • You cannot fill this prescription in a regular pharmacy. Your doctor, hospital, or clinic will provide this  medication because of possible complications or other issues.
  • This drug is likely to be covered under your medical benefit if you have insurance.

Amjevita/adalimumab-atto Cost, Side effects, Dosage, Uses for multiple inflammatory diseases

Read about Amjevita/adalimumab-atto Cost, Side effects, Dosage, Uses for multiple inflammatory diseases. Amjevita is manufactured by Amgen, Inc., of Thousand Oaks, California.

The U.S. Food and Drug Administration has approved a new biosimilar drug Amjevita that contains adalimumab-atto as an active pharmaceutical ingredient.Amjevita is a biosimilar to previously approved drug Humira manufactured by AbbVie Inc. of North Chicago, Illinois.

   
Amjevita/adalimumab-atto basic mechanism is inhibition or suppression tumor necrosis factor alpha (TNFa) which is main culprit for inflammatory response in inflammatory diseases (auto-immune) like rheumatoid arthritis, psoriatric arthritis, ankylosing spondylitis etc.It was observed during clinical trial that administration of adalimumab and methotrexate (MTX) provide synergistic effect and doubles the therapeutic efficacy of methotrexate. Apart from these indications Amjevita/adalimumab-atto can also be used in a patho-physiological condition where suppression of immune system is required. This drug is administered through subcutaneous route (sc).

Multiple inflammatory diseases is a group of disorders that belongs to malfunctioning of immune system. Most common examples of these diseases are rheumatoid arthritis, ulcerative colitis, crohn's disease, hidradenitis suppurativa, juvenile idiopathic arthritis. All kinds of auto-immune disorders are treated and managed by following combination of therapy like DMARD's, Immunosuppressants, Steroidal drugs, etc.

Amjevita/adalimumab-atto Cost, Side effects, Dosage, Uses for multiple inflammatory diseases

 Amjevita/adalimumab-atto Side effects


Amjevita is a biosimilar of Humira  so, both have almost same kind of indications and side effects. These side effects can be categorized into moderate to severe.

Moderate Side effects 

  • Generalized weakness
  • feeling of numbness
  • Body pain
  • Shortness of breath
  • vision problems
  • skin rashes
  • swelling on body

Severe Side effects

Severe kind of side effects associated with this drugs are increase risk of

  • Infections like respiratory infection, liver and kidney infection.
  • Malignancy  

Amjevita/adalimumab-atto Uses

U.S FDA approved this drug for multiple inflammatory diseases which is a class of auto-immune disorders. Auto-immune disorders are of many types like rheumatoid arthritis, ulcerative colitis, crohn's disease, hidradenitis suppurativa, juvenile idiopathic arthritis. This drug can also be used in combination with other drugs like methotrexate.

Amjevita/adalimumab-atto Dosage

This drug is formulated as pre-filled syringe with potency of 40mg/0.8ml. Standard dosage of amevita/adalimumab  is 40mg after every two weeks. It is administered subcutaneously and dose may be adjusted depending upon the severity of disease and patient condition. During this therapy your health care provider may also prescribe you some other DMARD's like methotrexate to make the treatment more effective.

Amjevita/adalimumab-atto Cost/Price 

According to market survey this drug is currently not available at retail pharmacies because it is recently approved by FDA and is under manufacturing process. Once, it will be available at retail outlets we will let you know about the unit cost of drug and its dosage frequency.

Exondys 51/eteplirsen Cost, side effects, Mechanism, Dosage for Duchenne muscular dystrophy (DMD)

Read all about Exondys 51/eteplirsen Cost, side effects, Uses, Dosage for Duchenne muscular dystrophy (DMD). Exondys 51 is made by Sarepta Therapeutics of Cambridge, Massachusetts.

US FDA approved a new novel drug Exondys 51 for the treatment of Duchenne muscular dystrophy (DMD). This drug contains eteplirsen as an active ingredient. Exondys 51/eteplirsen specifically targets mutations that occurs in DMD gene.This drug has been approved only for the treatment and management of Duchenne muscular dystrophy (DMD) but it does not mean that it cures it forever.

Duchenne muscular dystrophy (DMD) is rare kind of disorder but it is very devastating degenerative disease. In this disease some mutational changes occur in DMD gene which leads to alteration in DMD RNA transcription process. This altered DMD RNA becomes non-functional or in-active and does not bind or recognize dystrophin protein. This is the main root cause of Duchenne muscular dystrophy (DMD).

Exondys 51/eteplirsen Mechanism of Action or Pharmacology


Exondys 51/eteplirsen is  morpholino antisense oligomer that causes cleavage of exon 51 (part of a gene that will encode a part of the final mature RNA) during pre mRNA splicing phase of dystrophin protein.This process will generate a functional but modified form of dystrophin protein (skipping exon therapeutically) that can reinstate the binding process that was impaired due to genetic mutations.

The whole process initiated by this drug does not cure this problem but reduce the severity, progression and degeneration. Majority of patients suffering from DMD have this kind of mutation and can be treated effectively with the help of this therapeutic drug Exondys 51/eteplirsen.

Exondys 51/eteplirsen Cost, side effects, Mechanism, Dosage for Duchenne muscular dystrophy (DMD)


Exondys 51/eteplirsen Side effects

According to clinical trials this drug exhibited some minor side effects but no life threatening side effect was reported at that time. These minor side effects were

  • Balance disorder
  • Nausea
  • Vomiting
  • Headache
  • Dizziness
  • palpitation

This drug is administered in form of infusion through intra-venous route only.

Exondys 51/eteplirsen Dosage

This drug is formulated as a single dose vial with potency of 50mg/ml. In adult DMD patients  its standard dosage is 30mg/Kg through intravenous route once in a week. Dose titration may be considered depending upon the patient condition and severity of disease. 

Exondys 51/eteplirsen Cost/Price

This drug is administered by your healthcare practitioner (HCP), which usually means:
  • It may comes under special items category.
  • You cannot fill this prescription in a regular pharmacy. Your doctor, hospital, or clinic will provide this  medication because of possible complications or other issues.
  • This drug is likely to be covered under your medical benefit if you have insurance.

Erelzi Cost, Side effects, Uses, Dosage for Multiple Inflammatory Diseases

Erelzi Cost, Side effects, Uses, Dosage for Multiple Inflammatory Diseases. Erelzi is manufactured by Sandoz Inc., based in Princeton, New Jersey, at Novartis Pharma in Stein, Switzerland.

US Food and Drug Administration approved a new bio-similar drug Erelzi that contains active ingredient etanercept-szzs for the treatment of multiple inflammatory disease. Multiple Inflammatory disease includes rheumatoid arthritis (RA) which is swelling of joints and periphery tissues along with inflammation, systemic lupus erythematosus (SLE) which causes inflammation and swelling of skin, joints, kidneys, brain, and other organs and metabolic system disease like celiac sprue disease in which intestine produces inflammatory response upon gluten (barley, rye and wheat) intake that causes damage to the lining of the small intestine.

Erelzi can be used in combination with DMARD's ( disease modifying anti-rheumatic drugs) like methotrexate for the treatment of psoriatic arthritis, ankylosing spondylitis, plaque psoriasis and other auto-immune disorders. Erelzi should be used with caution because it may increase the risk of infections like T.B (tuberculosis), histoplasmosis, live and kidney disease. Erelzi should be used only in case where no appropriate alternative is available because etanercept containing products may increase the risk of malignancy upon prolong intake. Erelzi should not be administered to patients with sepsis.


Erelzi Cost, Side effects, Uses, Dosage for Multiple Inflammatory Diseases
Erelzi Cost, Side effects, Uses, Dosage for Multiple Inflammatory Diseases

 Erelzi Side effects

During clinical trials Erelzi shows some side effects that were moderate to severe. There side effects are

Moderate Side effects


  • Rashes
  • Nausea
  • Vomiting
  • Dyspepsia
  • Abdominal pain
  • Fatigue

Severe Side effects

  • Increased risk of malignancy
  • Increased risk of tuberculosis
  • Increased risk of fungal infection (histoplasmosis)
  • Increased risk of sepsis. 

Erelzi Prescribing information or Uses


U.S FDA approved Erelzi for severe kind of multiple inflammatory disease like rheumatoid arthritis, Plaque arthritis, idiopathic juvenile arthritis, ankylosing spondylitis and other auto-immune diseases in combination with some other suitable agents like DMARD's.

Erelzi  Dosage

Standard dose of erelzi is 25mg two times in a week or 50mg once in a week. This drug is administered through subcutaneous route. If your doctor has prescribed  it you twice in a week then maintain a gap of 3-4 days between two consecutive doses. This drug may also be used in combination with other drugs like glucocorticoids,  methotrexate and NSAIDs.

Erelzi Cost/Price 


According to market survey this drug is currently not available at retail pharmacies and manufacturer has not yet provided any timeline for its release. Once, it will be available at retail outlets we will let you know about the unit cost of drug.

Adlyxin/lixisenatide Cost, Side effects, Dosage, Uses for Type 2 Diabetes

Adlyxin/lixisenatide Cost, Side effects, Dosage, Uses for Type 2 Diabetes. Adlyxin is manufactured by Sanofi-Aventis U.S. LLC, of Bridgewater, New Jersey.

Adlyxin with an active ingredient lixisenatide is the new drug approved by U.S. Food and Drug Administration on July 28, 2016. This drug is approved in parentral dosage form. It's dosage frequency is once a day and injected through subcutaneous route. Adlyxin/lixisenatide belongs to a class of drug called as a glucagon-like peptide-1 (GLP-1) receptor agonist. GLP-1 is hormone that helps in the regulation of blood sugar control.

Type 2 diabetes is a common problem in US population. In type 2 diabetes, insulin produces at normal level but insulin sensing receptors present in liver, kidney and other organ tissues become desensitize. This desensitization leads to improper or poor attachment of insulin at insulin bind receptors. Ultimately, patient loses his control over blood sugar and becomes diabetic.

Adlyxin is aimed to improve blood  sugar level along with exercise and dietary control because no single pill can efficiently control blood sugar control without taking further measures. Type 2 diabetes is a kind of disease that can be managed by taking medications along with life style modifications.

During clinical trails Adlyxin safety profile was quite satisfactory. Adlyxin is quite safe for patient having types 2 diabetes along with atheroseclerosis ( stenosis of arteries).  Adlyxin helps to improve blood sugar level with no harm to cardiac issues like angina, atrial fibrillation, tachycardia, thromboembolic phenomenon and atherosclerosis.

Adlyxin/lixisenatide Cost, Side effects, Dosage, Uses for Type 2 Diabetes


Adlyxin/lixisenatide Side effects


Adlyxin was tested for possible side effects during clinical trials. These side effects were mild moderate.
  • Nausea
  • Vomiting
  • Headache
  • Diarrhea
  • Dizziness
  • Hypersensitivity
  • Anaphylaxis
  • Asthenia
  • Muscle Weakness
  • Mild Fever
  • Rash at injection site
  • Loss of appetite 
 According to data received from clinical trials, Adlyxin does not have life threatening or lethal side effects.


 Adlyxin/lixisenatide Uses/Prescribing Information 

US FDA approved Adlyxin to control blood sugar level in type 2 diabetes. Adlyxin gives better control over blood sugar level if it used with other diabetes medications following life style modifications and dietary restrictions.

However, this drug was also tested as standalone therapy during clinical trials in which it is showed promising results. Adlyxin should not be used to treat people with type 1 diabetes or patients with increased ketones in their blood or urine (diabetic ketoacidosis).

 Adlyxin/lixisenatide Dosage

Adlyxin/lixisenatide pack contains two types of pen. One is green pen and other is bugendy pen. Green pen is 3mL prefilled pen and each ml contains 50mcg/ml dose. It is used as starter dose. It provides 14 dose of 10mcg/dose. Start with green pen and inject subcutaneously 10mcg/day for 14 days.

Now, on day 15 use burgundy pen as maintenance dose. Burgundy pen is also 3mL prefilled pen and each ml contains 100mcg/ml dose. It is used as maintenance dose. It provides 14 doses of 20mcg/dose. Inject subcutaneously 20mcg/day for 14 days.

 Adlyxin/lixisenatide Cost/Price 

This drug is now available at retail outlets with an average cost of 570$ to 620$ per pack. One pack of adlyxin conatins 2 prefilled syringes each of 3ml. This price may variate with the passage of time so, please make it confirm before purchasing.

Xiidra/lifitegrast Cost, Side effects, Dosage, Uses for Dry eye

Xiidra/lifitegrast Cost, Side effects, Dosage, Uses for Dry eye. Xiidra is manufactured by Shire US Inc., of Lexington, Massachusetts.

FDA has approved a new drug having active ingredient lifitegrast with brand name of Xiidra for the treatment of dry eye disease. This drug belongs to class termed as lymphocyte function-associated antigen 1 (LFA-1) antagonist. This is first kind of drug of its class approved for the treatment of dry eye disease. This drug is presented to FDA in the form of ophthalmic solution and marked as prescription only medicine.

Dryness of eyes is a common problem in elder people due to decrease activity of tears gland. Dryness of eye itself does cause any harm or damage to eye but it increases the risk of eye ulcer, corneal injury, difficulty in blinking, vision problem etc. About 5% of individuals having age 30 to 40 years have problem of dryness of eyes while people with age more than 65 years have 10% occurrence rate.

Most common reasons of eye dryness is inadequate production of tears or low consistency of ophthalmic fluid. These problem may arise due to extreme weather conditions like extreme hot or cold weather or too much air pressure.

About 1100 individuals were selected to assess the clinical efficacy and safety profile of Xiidra/lifitegrast. It shows satisfactory results in four randomized controlled clinical trials. During these clinical trials patients received lifitegrast eyedrops or placebo eyedrops twice daily 12 hours apart for 12 weeks.

 Xiidra/lifitegrast Cost, Side effects, Dosage, Uses for Dry eye


Xiidra/lifitegrast Side Effects

During clinical trials most common side effects observed were mild to moderate but there was no evidence of serious kind of side effects. Some common side effects were

  • Eye irritation
  • Blurred vision
  • Discomfort
  • Dysgeusia (Feeling unusual taste)
  • Headache
  • Burning sensation

Xiidra/lifitegrast Uses or Prescribing Information

FDA approved Xiidra/lifitegrast for treatment of dryness of eye in ophthalmic dosage form. Tin his drug is marked as prescription only medicine so you need a valid prescription in order to get this medicine.

Xiidra/lifitegrast Cost/Price

This drug was presented to FDA in ophthalmic dosage form with potency of  5% ophthalmic solution. Xiidra is now available in market with pack size of 60's. According to market survey initial cost or price of one box is about 400$ - 500$ that contains 60 ampules. This price may variate with the passage of time so, make it confirm by visiting your nearby pharmacy before purchasing.

Xiidra/lifitegrast Dosage

In adults, usual dosage frequency of xiidra is one drop into each eye after every 12hrs for 3-5 days depending upon the severity of disease. In children, xiidra safety profile has not yet evaluated.

Epclusa Cost, Side effects, Dosage, Uses for Hepatitis C infection

Epclusa Cost, Side effects, Dosage, Uses for Hepatitis C infection. Epclusa is manufactured and marketed by Gilead Sciences, Inc., of Foster City, California.

Epclusa  is first kind drug approved by US FDA for the treatment of all six major HCV genotypes. Epclusa contains combination of sofosbuvir, a drug approved by FDA as break through therapy for HCV and  velpatasvir, a new drug, and is the first to treat all six major forms of HCV.

US FDA approved this drug on July 28 2016 for the treatment of chronic type of hepatitis in adult patients with cirrhosis or without cirrhosis. If liver cirrhosis progresses to advance stage then Epclusa is used with antiviral drug called as ribavirin.

Hepatitis C is a viral infection leads towards liver cirrhosis if it persists for a long term. HCV virus has 6 genotypes 1 to 6. Each genotype requires duration of therapy and in some cases therapy may also be changed. In United States about 75% people have genotype 1 that means genotype 1 is the most common type in United States of America. Genotype 2 has prevalence rate of 25%. Other genotypes are less common and only few patients are diagnosed with such kind of genotypes.

Epclusa Cost, Side effects, Dosage, Uses for Hepatitis C infection
Epclusa Cost, Side effects, Dosage, Uses for Hepatitis C infection


Epclusa Side effects


There are two types of side effects that were observed during Epclusa clinical trials like moderate and severe type of side effects.

Moderate Side effects include  
  • Fatigue
  • Headache
  • Nausea 
  • Vomiting
  • Dizziness
  • Dry Cough
  • Fever
  • Myalgia
  • Stomach discomfort
  • Dryness
Severe Side effects include

  • Bradycardia 
  • Hypersensitivity
  • Cardiac arrhythmia 
Epclusa may interact with some other drugs for example it should not be used with amiodarone due to increase cardiac risks like rapid fluctuations in heart rate, severe bradycardia and cardiac arrest. Some drugs may reduce the serum level of epclusa which will reduce the efficacy of drug.

Epclusa Uses or Prescribing Information


Epclusa is prescribed for the treatment of chronic HCV infection in adults having liver cirrhosis or do not have liver cirrhosis. It indicated for all kinds of HCV genotypes because it contains combination of drugs. Up-till now, Epclusa is only regimen to treat all six major HCV genotypes effectively.

Epclusa Cost/Price


This drug is presented to FDA in tablet form (oral dosage form) with potency 400mg/100mg (Sofosbuvir 400mg and velpatasvir 100mg). According to market survey price of epclusa is variable but approximate average cost of one pack of epclusa ranges between 24,000$ - 26,000$. One pack of epclusa contains 28 tablets ( 28's pack size).  This price may variate with the passage of time so, make it confirm by visiting your nearby pharmacy before purchasing.

Epclusa Dosage

This drug is indicated for chronic hepatitis C in adults with genotype 1,2,3,4,5 and 6. According to clinical data provided by health authorities the dosage frequency is once a day through oral route (PO). Duration of therapy depends upon patient liver condition and genotype. However, average duration of therapy is between 4-6 months. This drug my be used in combination with other antiviral drugs for targeted therapy.

Ocaliva/obeticholic acid Cost, Side effects, Dosage, Uses in primary biliary cholangitis

Ocaliva/obeticholic acid Cost, Side effects, Dosage, Uses in primary biliary cholangitis. Ocaliva is manufactured by New York, New York-based Intercept Pharmaceuticals, Inc.

Food and Drug Administration has approved Ocaliva that contains active ingredient obeticholic acid for the treatment of primary biliary cholangitis (PBC). FDA proposed this drug  to treat primary biliary cholangitis (PBC) in combination with ursodeoxycholic acid (UDCA) in adults with an inadequate response to ursodeoxycholic acid, or as a single therapy in adults unable to tolerate UDCA.

Ocaliva, given orally, ties to the farnesoid X receptor (FXR), a receptor found in the core of cells in the liver and digestive system. FXR is a key controller of hepatic metabolic pathways. Ocaliva expands bile stream from the liver and stifles bile acid creation in the liver, in this way decreasing the exposure of the liver to lethal levels of biliary contents.

PBC is an chronic, or long lasting, illness that causes blockage of biliary system in the liver to end up kindled, harmed and at last pulverized. This causes bile to stay in the liver, which harms the liver cells after some time, and results in cirrhosis, or scarring of the liver. As cirrhosis advances, and the measure of scar tissue in the liver expands, the liver loses its capacity to work.
Ocaliva/obeticholic acid Cost, Side effects, Dosage, Uses in primary biliary cholangitis
Ocaliva/obeticholic acid Cost, Side effects, Dosage, Uses in primary biliary cholangitis

Ocaliva Side effects

The most common side effects of Ocaliva are

  • Pain in the middle part of the throat (oropharyngeal)
  • Severe itching of the skin (pruritus)
  • Abdominal pain and discomfort
  • Generalized weakness
  • Joint pain (arthralgia)
  • Fatigue
  • Dizziness
  • Constipation
  • Headache
  • Mild fever

Ocaliva should not be used in patients with complete biliary obstruction.

Ocaliva Uses or Prescribing information 

Patients left untreated, or who have not reacted to ursodeoxycholic acid, are at danger for liver cirrhosis and death. Ocaliva gives a vital treatment choice to patients living with initial biliary cholangitis who have not responded to the main other affirmed treatment, ursodeoxycholic acid.

Ocaliva is reserved for the treatment of initial biliary cholangitis in combination with ursodeoxycholic acid in grown-ups with a deficient response to ursodeoxycholic acid, or as a solitary treatment in grown-ups not able to endure ursodeoxycholic acid.

Ocaliva Cost/Price

According to market survey average cost of 30 ocaliva tablets with potency of 5mg is approximately 5840$ to 5890$. Similarly 30 ocaliva talets with potency of 10mg is approximately 6000$ to 6250$. This cost or price may vary due to number of factors like location, discount policy or coupon system. Ocaliva is now available in two pack size 30's and 90's. This price may variate with the passage of time so, make it confirm by visiting your nearby pharmacy before purchasing.

Ocaliva Dosage

Ocaliva is available in two potencies 5mg and 10mg. Usual dose of ocaliva at startup is 5mg orally every day. If it does not give adequate response after taking 2-3 weeks then dose may titerate up-to 10mg once a day. Dose should not be exceed 10mg/day.

Zinbryta/daclizumab Cost, Side effects, Uses, Dosage for multiple sclerosis

Zinbryta/daclizumab Cost, Side effects, Uses, Dosage for multiple sclerosis. Zinbryta is manufactured by Biogen, Inc. of Cambridge, Massachusetts.

The U.S. Food and Drug Administration has been approved Zinbryta that contains active ingredient daclizumab for the treatment of adults with relapsing forms of multiple sclerosis (MS). Zinbryta belongs to a class termed as monoclonal antibodies. Zinbryta is presented in parentral dosage form and categorized as long acting agent.

Zinbryta should be reserved for  those patients who have had a deficient response to combination therapy for multiple sclerosis (MS) on the grounds that Zinbryta has genuine dangers including liver damaging effects and modulation of immune system. In light of the dangers, Zinbryta has a boxed cautioning and is accessible just through a limited circulation program under a risk Evaluation and mitigation Strategy.

MS is a chronic, provocative, immune system malady of the focal sensory system that disturbs the co-ordination between the spinal region and different parts of the body. It is among the most widely recognized reasons for neurological disability in adults and happens more often in ladies than men. For the vast majority with MS, episodes of worsening function (relapses) are initially followed by recovery periods (remissions).


Zinbryta Side effects

The most common adverse reactions that wrere observed during Zinbryta therapy are
  • Cold symptoms (nasopharyngitis)
  •  Increased alanine aminotransferase
  • Throat (oropharyngeal) pain
  • Enlargement of lymph nodes
  • Upper respiratory tract infection
  • Rash
  • Influenza
  • Dermatitis
  • Eczema
  • Depression

 Zinbryta Uses or prescribing information

Due to serious side effects produced by Zinbryta it should be reserved for those patients who have had a deficient response to combination therapy for multiple sclerosis (MS) or relapsing forms of multiple sclerosis (MS)

The viability of Zinbryta was appeared in two clinical trials. One trial conducted at Zinbryta and Avonex in 1,841 members who were studied for 144 weeks. Patients on Zinbryta had less relapses than patients taking Avonex.

The second trial was conducted between Zinbryta and inactive agent (placebo) and included 412 members who were dealt with for 52 weeks. In that study, those accepting Zinbryta had less relapses as compared with those getting inactive agent.

Zinbryta Cost/Price

This drug is now available in market in a single-dose prefilled syringe with potency of 150mg/ml. According to market survey initial price of a single-dose prefilled syringe of zinbryta costs about 7000$ - 7600$. This price may variate with the passage of time so, make it confirm by visiting your nearby pharmacy before purchasing.

Zinbryta Dosage

In adults, usual dosage frequency of zinbryta is 150mg subcutaneously (SC) once in a month in case of recurrent episodes of multiple sclerosis. Dose titration may be required in case of liver impairment. In children, safety profile of zinbryta/daclizumab has not yet evaluated.

Tecentriq/atezolizumab Cost, Side effects, dosage, Uses for bladder cancer

Tecentriq/atezolizumab Cost, Side effects, dosage, Uses for bladder cancer. Tecentriq is marketed by Genentech based in San Francisco, California. The Ventana PD-L1 (SP142) assay complementary diagnostic for Tecentriq is marketed by Ventana Medical Systems, based in Tucson, Arizona.

Tecentriq acts on the PD-1/PD-L1 pathway (proteins found on the body's immune cells and some tumor cells). By blocking these co-ordinations, Tecentriq may help the body's defense system to cope with tumor cells. Tecentriq is the first FDA-affirmed PD-L1 inhibitor and the most recent in the broader class of PD-1/PD-L1 agent endorsed by the FDA in previous two years.

Tecentriq is reserved for the treatment of patients with locally progressed or metastatic urothelial carcinoma whose disease has became more severe after continuous administration of platinum-containing chemotherapy, or within range of 12 months of getting platinum-containing chemotherapy, either before (neoadjuvant) or after (adjuvant) surgical treatment. Urothelial carcinoma has high prevalence rate as compared to other type of bladder cancer. It takes place in the urinary system and spreads rapid to surrounding organs.




Tecentriq/atezolizumab Side effects

The safety and efficacy of Tecentriq were studied in a single-arm clinical trial involving 310 patients with locally advanced or metastatic urothelial carcinoma. Most common side effects that were observed during therapy are 
  • Urinary tract infection,
  • Decreased appetite, 
  • Nausea, 
  • Constipation
  • Fatigue,
  • Fever (pyrexia) 
  • Increased risk of infection 
  • Changes in immune system response
  • Rashes
  • Hypersensitivity

Tecentriq/atezolizumab Uses or Indications

FDA approved tecentriq/atezolizumab for the treatment of progressive or advance urothelial carcinoma. This drug is also indicated for those who have became more severe after continuous administration of platinum-containing chemotherapy, or within range of 12 months of getting platinum-containing chemotherapy, either before (neoadjuvant) or after (adjuvant) surgical treatment.

Tecentriq/atezolizumab Cost/Price

This drug is administered by your healthcare practitioner (HCP), which usually means:
  • It may comes under special items category.
  • You cannot fill this prescription in a regular pharmacy. Your doctor, hospital, or clinic will provide this  medication because of possible complications or other issues.
  • This drug is likely to be covered under your medical benefit if you have insurance.

Tecentriq/atezolizumab Dosage

The usual dosage of tecentriq/atezolizumab is 1200 mg IV q3wk at rate 60min per infusion. This dosage frequency may be titrated in case of toxicity or increase the dosage in special instances to slow down the progression. 

Nuplazid/pimavanserin Cost, Side effects, Dosage, Prescribing Info

Nuplazid/pimavanserin Cost, Side effects, Dosage, Prescribing Info. Nuplazid is marketed by Acadia Pharmaceuticals Inc. of San Diego, California.

 The U.S. Food and Drug Administration approved Nuplazid containing active ingredient pimavanserin in tablet dosage form for the treatment of hallucinations and delusions associated with psychosis experienced by some people with Parkinson’s disease.

Nuplazid was granted breakthrough therapy designation for the treatment of hallucinations and delusions associated with Parkinson’s disease. Breakthrough therapy designation is a program designed to expedite the development and review of drugs that are intended to treat a serious condition and where preliminary clinical evidence indicates that the drug may demonstrate substantial improvement over available therapy on a clinically significant endpoint.

The neurological issue normally happens in individuals over age 60, when cells in the cerebrum that deliver a compound called dopamine get to be impeded or pass on. Dopamine transmits signals between the zones of the brain that create smooth development - like eating, composing and shaving.

Early indications of the ailment are unpretentious and happen step by step. In some individuals Parkinson's illness advances more rapidly than in others. As the ailment advances, the shaking, or tremor, which influences many individuals with Parkinson's sickness, may start to meddle with every day activities. Different side effects may incorporate despondency and other passionate changes; mind flights and fancies; trouble in gulping, biting, and talking; urinary issues or stoppage; skin issues; and difficulty in sleeping.


Nuplazid/pimavanserin Cost, Side effects, Dosage, Prescribing Info

Nuplazid/pimavanserin Side effects

Likewise with other atypical antipsychotic drugs, Nuplazid has a Boxed Warning cautioning medicinal services experts around an expanded danger of death connected with the utilization of these medications to treat more established individuals with dementia related psychosis. No medication in this class is affirmed to treat patients with dementia-related psychosis.

The most common side effects of nuplazid observed during clinical trials are
  • Swelling ankles, legs, and feet due to the accumulation of excessive fluid in the tissue
  • Nausea
  • Abnormal state of mind (confused state)
  •  Peripheral edema
  • Fever
  • Headache
  • Body pain

Nuplazid/pimavanserin Uses or Indications

Nuplazid containing active ingredient pimavanserin in tablet dosage form is used for the treatment of hallucinations and delusions associated with psychosis experienced by some people with Parkinson’s disease.

Nuplazid/pimavanserin Cost/Price

This drug is presented to FDA in tablet dosage for. According to market survey this drug is now available with pack size of 30 tablets (30's) and its potency is 17mg. Cost or Price of each pack containing 30 tablets ranges from 990$ - 1030$. Few retail outlets may offer you discount on nuplazid pack if you give them nuplazid discount coupon.This price may variate with the passage of time so, make it confirm by visiting your nearby pharmacy before purchasing.

Nuplazid/pimavanserin Dosage

Nuplazid is indicated for treatment of hallucinations and delusions associated with Parkinson disease psychosis. It's usual dosage for adults is 34 mg PO qDay (without titration). However, safety profile of nuplazid regarding its use in children has not yet established.

Venclexta/venetoclax Cost, Side effects, Uses for chronic lymphocytic leukemia

Venclexta/venetoclax Cost, Side effects, Uses for chronic lymphocytic leukemia. Venclexta is manufactured by AbbVie Inc. of North Chicago, Illinois, and marketed by AbbVie and Genentech USA Inc. of South San Francisco, California. The Vysis CLL FISH probe kit is manufactured by Abbott Molecular of Des Plaines, Illinois.

 Venclexta is indicated for daily use after detection of 17p deletion is confirmed through the use of the FDA-approved companion diagnostic Vysis CLL FISH probe kit. Venclexta is the first FDA-approved treatment that targets the B-cell lymphoma 2 (BCL-2) protein, which supports cancer cell growth and is overexpressed in many patients with CLL.

Chronic Lymphocytic Leukemia is one of the most common types of leukemia in adults, with approximately 15,000 new cases diagnosed each year. CLL is characterized by the progressive accumulation of abnormal lymphocytes, a type of white blood cell. Patients with CLL who have a 17p deletion lack a portion of the chromosome that acts to suppress cancer growth. This chromosomal abnormality occurs in approximately 10 percent of patients with untreated CLL and in approximately 20 percent of patients with relapsed CLL.

Venclexta/venetoclax Cost, Side effects, Uses for chronic lymphocytic leukemia


Venclexta/venetoclax Side effects

The most common side effects of Venclexta include

  • Low white blood cell count
  • Diarrhea
  • Nausea
  • Anemia
  • Upper respiratory tract infection
  • Low platelet count (thrombocytopenia)
  • Fatigue. 

Serious complications can include 

  • Pneumonia
  • Neutropenia with fever
  • Fever
  • Autoimmune hemolytic anemia
  • Anemia
  • Metabolic abnormalities known as tumor lysis syndrome. 
  • Live attenuated vaccines should not be given to patients taking Venclexta.

 Venclexta/venetoclax Uses

Venclexta is used for the treatment of patients with chronic lymphocytic leukemia (CLL) who have a chromosomal abnormality called 17p deletion and who have been treated with at least one prior therapy.

 Venclexta/venetoclax Cost/Price

Venclexta is now available in market with potency of 10mg, 50mg and 100mg. Pack size of venclexta include 2's, 7's and 14's. Average cost or price of one pack of venclexta 10mg is 125$-130$. This price may variate with the passage of time so, make it confirm by visiting your nearby pharmacy before purchasing.

 Venclexta/venetoclax Dosage

Venclexta dosing frequency may depend upon you condition and severity of disease. However standard dosing frequency is  20mg once a day for 1 week and then you may increase the potency of dose up-to 100mg with same frequency.

Cinqair/reslizumab Cost, Side effects, Uses for asthma

Read about Cinqair/reslizumab Cost, Side effects, Uses for asthma. Cinqair is made by Teva Pharmaceuticals in Frazer, Pennsylvania.

Asthma is a chronic disease that causes inflammation in the airways of the lungs. During an asthma attack, airways become narrow making it hard to breathe. Severe asthma attacks can lead to asthma-related hospitalizations because these attacks can be serious and even life-threatening.

Cinqair is administered once every four weeks via intravenous infusion by a health care professional in a clinical setting prepared to manage anaphylaxis. Cinqair is a humanized interleukin-5 antagonist monoclonal antibody produced by recombinant DNA technology in murine myeloma non-secreting 0 (NS0) cells. Cinqair reduces severe asthma attacks by reducing the levels of blood eosinophils, a type of white blood cell that contributes to the development of asthma.

According to the Centers for Disease Control and Prevention, as of 2013, more than 22 million people in the U.S. have asthma, and there are more than 400,000 asthma-related hospitalizations each year.


This drug is presented to FDA in capsule dosage form but it’s potency and dosage frequency is difficult to evaluate until it appears in the market. So, we will update all the parameters of drug once, it gets available in the market.


Cinqair/reslizumab Side effects

Cinqair can cause serious side effects including
  • Allergic (hypersensitivity) reactions
  • Anaphylactic shock
These reactions can be life-threatening.

The most common side effects in clinical trials for Cinqair included anaphylaxis, cancer, and muscle pain.
  • Skin rash (hives)
  • Swelling of your face, lips, mouth, or tongue
  • Symptoms of low blood pressure (fainting, dizziness, light headache, confusion, fast heart beat)
  • Itching
  • Paleness
  • Flushing
  • Nausea or abdominal discomfort
  • Breathing problems

Cinqair/reslizumab Prescribing Information

Cinqair is approved for patients who have a history of severe asthma attacks (exacerbation's) despite receiving their current asthma medicines.

Cinqair/reslizumab Cost/Price

This drug is administered by your healthcare practitioner (HCP), which usually means:
  • It may comes under special items category.
  • You cannot fill this prescription in a regular pharmacy. Your doctor, hospital, or clinic will provide this  medication because of possible complications or other issues.
  • This drug is likely to be covered under your medical benefit if you have insurance.

Cinqair/reslizumab Dosage 

Cinqair is administered by intravenous (IV) infusion according weight of body 3 mg/kg one time in every 4 weeks. This dose frequency and potency may be adjusted by your health care provider depending upon disease condition.

Taltz/ixekizumab Cost, Side effects, Uses for Psoriasis

Read about Taltz/ixekizumab Cost, Side effects, Uses for Psoriasis. Taltz is marketed by Indanapolis, Indiana-based Eli Lilly and Company.

Taltz is administered as an injection. It is intended for patients who are candidates for systemic therapy (treatment using substances that travel through the bloodstream, after being taken by mouth or injected), phototherapy (ultraviolet light treatment) or a combination of both.

Taltz’s active ingredient is an antibody (ixekizumab) that binds to a protein (interleukin (IL)-17A) that causes inflammation. By binding to the protein, ixekizumab is able to inhibit the inflammatory response that plays a role in the development of plaque psoriasis.

Psoriasis is a skin condition that causes patches of skin redness and flaking. Psoriasis is an autoimmune disorder that occurs more commonly in patients with a family history of the disease, and most often begins in people between the ages of 15 and 35. The most common form of psoriasis is plaque psoriasis, in which patients develop thick, red skin with flaky, silver-white scales.

Taltz/ixekizumab Cost, Side effects, Uses for Psoriasis

Taltz/ixekizumab  Side effects

  • Serious allergic reactions and development or worsening of inflammatory bowel disease have been reported with the use of Taltz. Monitor patients closely for these conditions. 
  • The most common side effects include upper respiratory infections, injection site reactions and fungal (tinea) infections.

Taltz/ixekizumab  Prescribing Information

US FDA has approved this medicine to treat adults with moderate-to-severe plaque psoriasis.

Taltz/ixekizumab Dosage

 This drug is formulated as pre-filled single syringe having drug volume 80mg/ml. Dosage frequency of this drug is160mg subcutaneously at first week then 80mg subcutaneously every second week (q2wks). After the administration of 7th dose administer 80mg subcutaneously every fourth week (SC q4wks). 

Taltz/ixekizumab Cost/Price

Single pack that contains 1 syringe of Taltz 80mg/ml costs about 5000$ to 4000$. This price may variate with the passage of time so, make it confirm by visiting your nearby pharmacy before purchasing.

Anthim (obiltoxaximab) Side effects, Cost, Uses, for Anthrax

Read about Anthim (obiltoxaximab) Side effects, Cost, Uses, for Anthrax. Anthim was developed by Elusys Therapeutics, Inc. of Pine Brook, New Jersey, in conjunction with the U.S. Department of Health and Human Services’ Biomedical Advanced Research and Development Authority.

U.S. Food and Drug Administration approved Anthim (obiltoxaximab) injection to treat inhalational anthrax in combination with appropriate antibacterial drugs. Anthim is also approved to prevent inhalational anthrax when alternative therapies are not available or not appropriate.

 Inhalational anthrax is a rare disease that can occur after exposure to infected animals or contaminated animal products, or as a result of an intentional release of anthrax spores. It is caused by breathing in the spores of the bacterium Bacillus anthracis. When inhaled, the anthrax bacteria replicate in the body and produce toxins that can cause massive and irreversible tissue injury and death. Anthrax is a potential bioterrorism threat because the spores are resistant to destruction and can be spread by release in the air.

Anthim is a monoclonal antibody that neutralizes toxins produced by B. anthracis. Anthim was approved under the FDA’s Animal Rule, which allows efficacy findings from adequate and well-controlled animal studies to support FDA approval when it is not feasible or ethical to conduct efficacy trials in humans.


Anthim (obiltoxaximab) Side effects, Cost, Uses, for Anthrax


 Anthim (obiltoxaximab) Side effects

 The safety of Anthim was evaluated in 320 healthy human volunteers. The most frequently reported side effects were
  • Headache
  • Itching (pruritus)
  • Upper respiratory tract infections
  • Cough
  • Nasal congestion
  • Hives
  • Bruising
  • Swelling
  • Pain at the infusion site

 Anthim (obiltoxaximab) Prescribing Information

Anthim (obiltoxaximab) injection is prescribed to treat inhalational anthrax in combination with appropriate antibacterial drugs. Anthim is also prescribed to prevent inhalational anthrax when alternative therapies are not available or not appropriate.

 Anthim (obiltoxaximab) Dosage

This drug is formulated as single-dose vial having 600mg/6mL (100mg/mL) solution of obiltoxaximab/anthim. However, standard dosage frequency of anthim is 16 mg/kg IV for those having weight 40Kg or less. Similarly, for those having weight more than 40Kg dosage frequency should be 24 mg/kg IV.

Anthim (obiltoxaximab) Cost/Price

This drug is administered by your healthcare practitioner (HCP), which usually means:
  • It may comes under special items category.
  • You cannot fill this prescription in a regular pharmacy. Your doctor, hospital, or clinic will provide this  medication because of possible complications or other issues.
  • This drug is likely to be covered under your medical benefit if you have insurance.

Xalkori Cost, Side effects, Uses for lung cancer

Read about Xalkori Cost, Side effects, Uses for lung cancer. Xalkori is marketed by Pfizer, based in New York, New York.

 The U.S. Food and Drug Administration approved Xalkori (crizotinib) to treat people with advanced (metastatic) non-small cell lung cancer (NSCLC) whose tumors have an ROS-1 gene alteration. Xalkori is the first and only FDA approved treatment for patients with ROS-1 positive NSCLC.

 Xalkori is an oral medication that blocks the activity of the ROS-1 protein in tumors that have ROS-1 gene alterations. This effect on ROS-1 may prevent NSCLC from growing and spreading.

 Lung cancer is the leading cause of cancer-related deaths in the United States, with an estimated 221,200 new diagnoses and 158,040 deaths in 2015, according to the National Cancer Institute.  ROS-1 gene alterations, thought to lead to abnormal cells, have been identified in various cancers, including NSCLC. ROS-1 gene alterations are present in approximately 1 percent of patients with NSCLC.

Xalkori Cost, Side effects, Uses for lung cancer

Xalkori Side effects

The most common side effects of Xalkori are
  1. Vision disorders
  2. Nausea, diarrhea
  3. Vomiting, swelling (edema)
  4. Constipation
  5. liver problems (elevated transaminases)
  6. Fatigue, decreased appetite
  7. Upper respiratory infection
  8. Dizziness and numbness
  9. Tingling in the hands or feet (neuropathy). 
  10. Fatal inflammation of the lungs
  11. Abnormal heartbeats and partial
  12.  Complete loss of vision in one or both eyes

 Xalkori Cost and Dosage

Xalkori has 200mg potency and 250mg potency. One pack of Xalkori contains 60 capsules. Cost of 200mg Xalkori pack is £51,027 and 250mg is £51,600 approximately. This price may variate with the passage of time so, make it confirm by visiting your nearby pharmacy before purchasing.

Dosing interruption and/or dose reduction to 200 mg PO q12hr may be required based on safety and tolerability; decrease to 250 mg PO qDay if further reduction is needed.