Xadago/safinamide Cost, Side effects, Dosage, Uses for Parkinson’s disease

The FDA granted approval of Xadago to Newron Pharmaceuticals.

US FDA approved a new drug that contains active ingredient safinamide as an adjuvant therapy for the treatment of  Parkinson disease. According to FDA this drug should be used as add on therapy when other Parkinson medications such levodopa or carbidopa does not provide adequate response or symptoms of Parkinson may get worse (off episodes).

Parkinson disease (PD) is a characterized as degenerative disorders that affects motor functions as well as activities related to central nervous system. Disease onset is slow but it remains lifetime and symptoms of parkinson disease may become severe with the passage of time. In advance stages, this disease may lead to further irreversible changes like dementia. Most common manifestations of this disease are mood changes, cognitive impairment, speech difficulty, tremors, rigidity, difficulty in movements etc. The exact underlying cause this disease is still unclear but many scientist
believed that genetic predisposition and certain environment factors play important in role in pathogenesis of Parkinson disease.

Xadago has dual mechanism of action based to increase concentration of dopamine on pre-synaptic cleft by reversible  inhibition of MAO-B and of dopamine uptake and creases the induction of glutamate release. End point of all Parkinson based medications is inducing the release of dopamine on pre-synaptic cleft, reducing the degradation of dopamine neurotransmitter or inhibition of dopamine re-uptake.


Xadagosafinamide Cost, Side effects, Dosage, Uses for Parkinson’s disease


Xadago/safinamide Side effects


According to data obtained from clinical trials of Xadago/safinamide side effects are categorized as common side effects and less common side effects.

Common Side effects

  • Nausea 
  • Vomiting
  • Difficulty in sleeping
  • Insomnia 
  • Uncontrolled movements

Less common Side effects

  • Hyperprexia
  • hypertension
  • serotonin syndrome
  • agitation
  • retinal problems

Xadago/safinamide Uses

FDA approved Xadago for the treatment of Parkinson disease in patients who experience "off episode" e.g symptoms are getting worse even after using Parkinson base medications like dopa drugs. In that case Xadago is helpful and patient can take this drug as add on therapy.

Xadago/safinamide Cost and Dosage

According to market survey this drug is currently not available at retail pharmacies because it is recently approved by FDA and is under manufacturing process. Once, it will be available at retail outlets we will let you know about the unit cost of drug and its dosage frequency.

Noctiva/desmopressin Cost, Side effects, Dosage, Uses for Frequent Urination

Noctiva is marketed by Milford, Pennsylvania-based Renaissance Lakewood, LLC for Serenity Pharmaceuticals, LLC.

US FDA approved a new medicine noctiva with active ingredient desmopressin acetate in nasal preparation for the treatment of frequent urination or overproduction of urine during sleep time (polyuria). This is first kind of drug approved by FDA to reduce symptoms of frequent urination at night time.

Urgency to urinate at night time is termed as nocturia while the underlying cause of nocturia is over production of urine at night time is termed polyuria. Polyuria is not the only cause of nocturia it might be due to number of reasons like congestive heart failure, daibetes insipidus, diabetes mellitus, hyper active bladder, benign prostate hyperplasia, drug induced nocturia etc. So, it is the responsibility of health care provider to rule out the underlying causes of nocturia before prescribing this medicine because the drug is effective only in case of nocturia induced by nocturnal polyuria. 

Basic mechanism of action by which desmopressin reduces the urinary frequency is that it limits the amount of water in urine in renal collecting duct by binding with V2 receptors. According to pharmacokinetics, desmopressing has longer duration of action as compared to vasopression due to slow metabolic degradation. Moreover, it has better safety profile as compared to vasopressin.

Noctiva/desmopressin Cost, Side effects, Dosage, Uses for Frequent Urination

Noctiva/desmopressin Side effects

According to data received from clinical trials side effects ranges from moderate to severe. Mild to moderate side effects include nasal irritation or nasal discomfort, sneezing, nasal congestion, dizziness, hypertension. While severe kind of side effects include hyponatremia, cardiovascular events and blood pressure problem.

Noctiva/desmopressin Uses

FDA approved Noctiva for the treatment of nocturia associated nocturnal polyuria in adults. Initially start with low dose to minimize the risk of hyponatremia ( low sodium level in serum). This drug is not recommended for the treatment of nocturia in pregnant women.

Noctiva/desmopressin Cost and Dosage

According to market survey this drug is currently not available at retail pharmacies because it is recently approved by FDA and is under manufacturing process. Once, it will be available at retail outlets we will let you know about the unit cost of drug and its dosage frequency.

Odactra Cost, Side effects, Dosage, Uses for dust mite allergies

Odactra is manufactured for Merck, Sharp & Dohme Corp., (a subsidiary of Merck and Co., Inc., Whitehouse Station, N.J.) by Catalent Pharma Solutions Limited, United Kingdom.

US FDA approved new medicine odactra that contains allergen extract as an active ingredient. It is administered via sublingual route to treat allergic rhinitis with or without eye inflammation. This drug is suitable for people having age between 18years to 65years. Allergic rhinitis is very problem in among all populations without regard to age, gender and physical health. In some areas dust mite is the leading cause of allergic rhinitis found in the house dust, under mattress or carpets, inside the wooden material and in bed sheets. Their tiny structure allow them to hide easily around rough wooden corners, doors or anywhere they found dust.

Allergic rhinitis is basically inflammation and irritation inside the nasal passage due to inflammatory response triggered by inflammatory mediators like histamine etc. Basic mechanism of action by which odactra reduces this inflammation and irritation is desensitization to hose dust mite allergens. It is some kind of immunotherapy in which desensitization is carried out against the causative allergen. After the desensitization process patient becomes non-reactive or less reactive (hypo-allergic) to specific allergen.

Odactra Cost, Side effects, Dosage, Uses for dust mite allergies

Odactra Side effects

According to data received from clinical trails this drug may cause life threatening allergic reactions so, it's first dose must be administered under the supervision of a health care professional. According to FDA, product literature includes a boxed warning of severe allergic reactions can occur. Some other
mild to moderate kind of side effects are
  • Nausea
  • Vomiting
  • Itching in the ears and mouth
  • Swelling of the lips and tongue
  • Mucousal irritation
  • Skin allergy
  • Mild fever

Odactra Uses

FDA approved this drug for the treatment of dust mite induced allergic rhinitis. Though it can be easily administered through sublingual route but due to risk of fatal allergic reaction first dose of this drug must be administered under the supervision of health care professional.

Odactra Dosage

Standard dosage frequency of odactra for the treatment of  house dust mite (HDM) allergy or allergic rhinitis is one tablet sublingually once a day in adults. Safety profile of drug has not yet evaluated in pediatric and geriatric patients. 

Odactra Cost

According to market survey this drug is currently not available at retail pharmacies because it is recently approved by FDA and is under manufacturing process. Once, it will be available at retail outlets we will let you know about the unit cost of drug and its dosage frequency.

Siliq/brodalumab Cost, Side effects, Dosage, Uses for Psoriasis

Siliq is marketed by Bridgewater, New Jersey-based Valeant Pharmaceuticals.

U.S FDA approved new medicine siliq that contains active drug brodalumab for the treatment of psoriasis in adults. Psoriasis is a common auto-immune disorder in among all populations. Psoriasis might be of different types like plaque psoriasis, guttate psoriasis, erythrodermic psoriasis, inverse psoriasis and postular psoriasis. FDA approved Siliq for moderate to severe plaque psoriasis in adults.

Plaque psoriasis is basically a skin disorder that intense irritation and itching on skin and leaves the skin scaly or flaky along with reddish color appearance of skin. This condition may occur without regard to gender, age or ethnicity. However, it is commonly observed that people who have family history of plaque psoriasis or other are more prone to get involved in such disorder.

Siliq/brodalumab belongs to a group termed as monoclonal antibody. Basic mechanism by which brodalumab targets plaque psoriasis is that it binds to receptor interleukin-17 that generates inflammatory mediators to aggravate plaque psoriasis. Interleukin-17 does not activate after binding to brodalumab making it unable to release inflammatory mediators to make condition worse.

Siliq/brodalumab Cost, Side effects, Dosage, Uses for Psoriasis


Siliq/brodalumab  Side effects

During clinical trials drug exhibit some side effects or adverse effects experience by adult participants. These side effects were moderate to severe e.g
  • Fatigue
  • Diarrhea
  • Joint pain (arthralgia)
  • Headache
  • Injection site reactions
  • Influenza
  • low white blood cell count (neutropenia)
  • Fungal (tinea) infections
  • Throat pain (oropharyngeal pain)
  • Nausea, muscle pain (myalgia)   
  • Suicidal tendency 

Siliq/brodalumab Uses 

U.S FDA approved brodalumab for the treatment of  moderate to severe plaque psoriasis in adults. However, you healthcare provider (HCP) may recommend you a combined therapy in order to make treatment successful and better control over disease management.

Siliq/brodalumab Dosage

This drug will be available in the form of subcutaneous injection with potency of 210mg/1.5ml (single dose prefilled syringe). Standard dosage frequency of this drug is 210mg subcutaneously (SC) once in a week consecutively for 3 weeks and then 210mg subcutaneously (SC) after every two weeks.

Siliq/brodalumab Cost

Due to risk of suicidal ideation and behavior, the drug will come up with box warning and might be available through a restricted program under a Risk Evaluation and Mitigation Strategy (REMS) called the Siliq REMS Program. We will update you regarding its unit dose and dosage frequency whenever it is available in pharmacies under this program.

Emflaza/deflazacort Cost, Side effects, Dosage, Uses for Duchenne muscular dystrophy (DMD)

Emflaza is marketed by Marathon Pharmaceuticals of Northbrook, Illinois.

US FDA approved new medicine Emflaza that contains active ingredient deflazacort in oral dosage form for the treatment of Duchenne muscular dystrophy (DMD). Emflaza belongs to a therapeutic class termed as corticosteroids. Emflaza is basically a prodrug which is converted in active metabolite after its metabolism. All corticosteroids works by reducing swelling, inflammation and settling down the exaggerated immune response.

Duchenne muscular dystrophy (DMD) is a rare kind of genetic disorder that causes degeneration of muscles. Due to some genetic defect a protein termed as dystrophin does not produce in the body. The basic physiological role of dystrophin is keeping body muscles intact and healthy.

But dystrophin absence in Duchenne muscular dystrophy (DMD) makes muscle more vulnerable to degradation, degeneration and physical deterioration. Symptoms may first appear in the age of 5 years or earlier. After the onset of disease symptoms may get worst with the passage of time.

In extreme cases duchenne muscular dystrophy (DMD) may cause walking disability, cardiovascular or respiratory muscles collapse. These disabilities may appear at any time without regard to age. According to statistics this disease is more common in boys as compared to girls.

Emflaza/deflazacort Cost, Side effects, Dosage, Uses for Duchenne muscular dystrophy (DMD)

Emflaza/deflazacort Side effects

According to clinical data provided by health authorities Emflaza demonstarted a significant results over placebo. However, side effects were similar to other corticosteroids therapy. Most commonly observed side effects were as follows
  • Weight gain
  • Hair growth (hirsutism)
  • Central obesity
  • Facial puffiness (Cushingoid appearance)
  • Upper respiratory tract infection
  • Increased appetite
  • Urinary frequency
  • Cough 

Emflaza/deflazacort Uses/Prescribing information 

Though, number of corticosteroids are being used to muscular disorders like duchenne muscular dystrophy (DMD) But US FDA specifically approved Emflaza in oral dosage form for the treatment of  duchenne muscular dystrophy (DMD) in patients age 5 years and older.

 

Emflaza/deflazacort Dosage

According to medical literature provided this drug will come in following potencies 6mg, 18mg, 30mg and 36mg. Oral suspension of this drug will come up with potency of 22.75mg/mL. Drug will be administered according to body weight by following the standard of 0.9 mg/kg/day orally.

 

Emflaza/deflazacort Cost and Dosage

Emflaza is now avilable at retail outlets for end consumers. At this time, Emlfaza with potency of 6mg is only available in market in tablet form. Single pack of Emflaza has 30 tablets each tablet contains 6mg of deflazacort. Cost of single pack (30's) of Emflaza is between 7500$ to 8000$.This price may variate with the passage of time so, make it confirm by visiting your nearby pharmacy before purchasing.  

Trulance/Plecanatide Cost, Side effects, Dosage, Uses for Chronic Idiopathic Constipation (CIC)

Trulance is manufactured by New York, New York-based Synergy Pharmaceuticals Inc.

U.S FDA approved new drug Trulance that contains active ingredient plecanatide for the treatment of chronic idiopathic constipation in adults. Trulance/plecanatide belongs to a class termed as Uroguanylin analog. These agents increase the activation of guanyl cyclase C in the luminal area of intestines. Increase activation of guanyl cyclase C gives rise to fluid retention, intestinal motility and rapid intestinal transit time.

Constipation is very common problem in among all kind of populations. Constipation may occur in any person without regard to age or gender. There are number of reasons that trigger constipation problem like low or no fluid intake, impaired intestinal absorption, impaired intestinal motility, chronic disease of intestine, lack of fiber in the diet and last but not the least side effect of drugs like morphine.

Basic mechanism by which Trulance/plecanatide tones up intestinal motility is that it increases the activation of guanyl cyclase C (GC-C) in the luminal area of intestines. Such rise in activation of GCC leads to increase in cyclic guanosine monophosphate (cGMP), anion secretion,  fluid secretion, and intestinal transit. In this way it subsides the symptoms of constipation.


Trulance/Plecanatide Cost, Side effects, Dosage, Uses for Chronic Idiopathic Constipation (CIC)


Trulance/Plecanatide Side effects

According to clinical data provided by health authorities this drug is not suitable for children having age below six years. This drug withdraws some amount of water from intestines thus it will increase the risk of dehydration especially in children. In adult, following side effects were observed during clincal trails.
  • Dehydration
  • Severe Diarrhea
  • Intestinal Discomfort
  • Colic Pain
  • Increase in bowel motility
  • Headache
  • Nausea

Trulance/Plecanatide Uses or Prescribing Information

U.S FDA approved this drug for the treatment of chronic constipation of unknown origin (idiopathic) in adults. If patient is suffering from constipation due to known cause like low or no fluid intake, impaired intestinal motility or drug induced constipation then this drug should be avoided and root cause treatment should be followed. This drug is taken orally.

Trulance/Plecanatide Dosage


Standar dosage frequency of trulance in adults is 3mg once daily. However, its safety and efficacy has not yet evaluated in patients having age 6 yrs to <18 yrs

Trulance/Plecanatide Cost and Dosage


Trulance is now available at retail outlets. Single pack of this drug contains 30 tablets with potency 3mg of plecanatide per tablet. Cost of single Trulance pack ranges between 360$ to 390$. This price may variate with the passage of time so, make it confirm by visiting your nearby pharmacy before purchasing.

Spinraza/nusinersen Cost, Side effects, Dosage, Uses for spinal muscular atrophy

Spinraza is marketed by Biogen of Cambridge, Massachusetts and was developed by Ionis Pharmaceuticals of Carlsbad, California.

U.S FDA approved new medicine spinraza that contains active ingredient nusinersen  for the treatment of rare muscular disorder known as spinal muscular atrophy (SMA). FDA approves this drug in parenteral dosage form and a medical specialist is required to inject this drug because it is administered  into the fluid surrounding the spinal cord.

Spinal muscular atrophy is a rare kind of genetic disorder. Motor neurons are important to control motor functions of body like moving, driving, various muscular movements etc. Increase in number of dead motor neurons makes the co-ordination weak between brain and skeletal muscles. This will ultimately leads to the development of SMA (spinal muscular atrophy). However, certain risk factors that play important role in the development of SMA (spinal muscular atrophy) are genetic predisposition, age factor, auto-immune disease etc.

This drug belongs to antisense oligonucleotide family and can be used in all types of spinal muscular atrophy. It is injected through intrathecal route so, much care is required during its administration in order to avoid nerve damage. This drug has been received orphan drug designation which provides incentives to assist and encourage the development of drugs for rare diseases.


Spinraza/nusinersen Cost, Side effects, Dosage, Uses for spinal muscular atrophy

Spinraza/nusinersen Side effects

During initial clinical trials drug shows following side effects
  • Thromobocytopenia (low platelets count) 
  • Anemia (low RBC's count)
  • Increased risk of respiratory tract infection
  • Kidney damage (nephrotoxicity)
  • Brain damage (neurotoxicity)
  • Constipation
  • Headache
  • Dizziness
  • Hypersensitivity reactions
  • Skin rashes
  • Painful administration

Spinraza/nusinersen Uses or Prescribing information

U.S FDA approved this drug for all kinds of spinal muscular atrophy (SMA). This drug should be used once every 4 months after loading dose administration via intrathecal route. Care should be taken while injecting this drug to avoid any nerve damage.

Spinraza/nusinersen Dosage

This drug is manufacturing as single dose vial with potency of 12mg/5mL. Dosage of spinraza is diving into two phases.

Loading Dose: It includes 4 doses each of 12mg intrathecally. Administer first 3 doses at 14-day intervals and then administer 4th dose 30 days after the last (3rd) dose.

Maintainance Dose: It includes dose of 12 mg intrathecally per administration after every 4 months.

Spinraza/nusinersen Cost

This drug is administered by your healthcare practitioner (HCP), which usually means:
  • It may comes under special items category.
  • You cannot fill this prescription in a regular pharmacy. Your doctor, hospital, or clinic will provide this  medication because of possible complications or other issues.
  • This drug is likely to be covered under your medical benefit if you have insurance.

Rubraca/rucaparib Cost, Side effects, Dosage, Uses for advanced ovarian cancer

Rubraca is marketed by Clovis Oncology, Inc. based in Boulder, Colorado. 

U.S FDA assigned accelerated approval pathway to new medicine Rubraca that contains active ingredient rucaparib for the treatment of various types of ovarian cancer. According to FDA guidelines this drug should be used in progressive or advance type of ovarian cancer.

According to statistical data ovarian cancer is one of most leading type of cancer in women with high mortality rate. Ovarian cancer has multiple types some of which are idiopathic while others are due to mutation in specific genes e.g BRCA gene. Statistics shows that in United states approximately 20,000 to 22,000 women diagnosed with ovarian cancer annually and about 60 to 70 percent of these women die due to ovarian cancer. In united states most majority of women have ovarian cancer due to mutation of BRCA gene.

Rubraca/rucaparib achieved accelerated approval pathway due to its targeted action. Normally BRCA genes involves in the development of DNA but due to mutation in BRCA genes they produce altered DNA and give rise to tumor cells. rubraca/rucaparib works by blocking the enzyme (polymerase) that is necessary for DNA replication. This blockade will restrict the process of DNA replication or repairing, leading to cell death and possibly a slow-down or stoppage of tumor growth.

Rubraca/rucaparib Cost, Side effects, Dosage, Uses for advanced ovarian cancer


Rubraca/rucaparib Side effects


During clinical trails following side effects were reported in patient who were receiving this medicine

  • Low platelets count
  • Decrease in red blood cells
  • Difficulty in breathing
  • Changes in taste sensation
  • Fatigue
  • Nausea
  • Vomiting
  • Skin rashes

Rubraca/rucaparib Uses or Prescribing Information


U.S FDA granted its use in women who have advance ovarian cancer and one or more of the mutations of BRCA genes are detected, the patient may be eligible for treatment with Rubraca. However drug should be used with caution in patients who have bone marrow problem because this drug may cause myelodysplastic syndrome in those patients. This drug is not safe for fetus development so, always consult with your health care provide (hcp) before starting any medicine.

Rubraca/rucaparib Dosage


This drug is manufacturing in the form of tablets (Oral dosage form) with potency of 200mg and 300mg. Standard dosage frequency of Rubraca/rucaparib is 300mg tablet twice a day (BID) daily until disease progression reduced to maximum level. Dose adjustment may be required in case of severe side effects, hepatic or renal impairment. Safety profile of this drug has not yet evaluated in children.

Rubraca/rucaparib Cost 

This drug is now available in the market with an average cost of 3900$ to 3700$ per pack. There two potencies of rubraca 200mg and 300mg available in the market. Both have same pack size (30's). This price may variate with the passage of time so, make it confirm by visiting your nearby pharmacy before purchasing.

Eucrisa/crisaborole Cost, Side effects, Dosage, Uses for Eczema

Eucrisa is manufactured by Palo Alto, California-based Anacor Pharmaceuticals, Inc.

U.S FDA approved new drug Eucrisa that contains crisaborole as topical dosage form  (ointment) for the treatment of eczema ( atopic dermatitis) in patients having age 2 years or more. Eczema. Eczema or atopic dermatitis is a common skin disorder among all populations. It is intense form of skin disorder with an inflammatory response that requires long-term management or sometimes life time management in advance stages.

Exact underlying cause of eczema is not fully understood that triggers inflammatory response. It is proposed that genetic predisposition, environmental factors and immunogenic response play key role in the parthenogenesis of eczema. Most common symptoms of eczema include dry and red scaly appearance of affected area of skin with intense itching. Scratching may cause skin thickness along with swelling that prolongs the duration of therapy.

Main mechanism of Eucrisa/crisaborole is inhibition of  phosphodiesterase-4 that causes inflammation by triggering the release of certain inflammatory mediators like interleukin-12(IL-12), bradykinins, cytokinins and tumor necrosis factor (TNFα). As name indicates that it contains boron that penetrates readily and rapidly into skin is essential for its binding activity.

Eucrisa/crisaborole Cost, Side effects, Dosage, Uses for Eczema

Eucrisa/crisaborole Side effects

According to clinical data provided by health authorities following side effects were documented during clinical trials

  • Hypersensitivity reactions
  • Burning sensation
  • Sting like feeling
  • Mild pain during application

Eucrisa/crisaborole Uses or Prescribing information

U.S FDA approved only topical form of Eucrisa/crisaborole for the treatment eczema ( atopic dermatitis). Clinical data suggests that it should be applied two times a day to get better results. Eucrisa/crisaborole should not be used in patients having age less than 2 years.

Eucrisa/crisaborole Dosage

Eucrisa/crisaborole is manufacturing in the form of ointment with potency of 2%. Normally it should be applied in the form of thin layer topically to affected area twice a day. It should be used in case of mild to moderate kind of atopic dermatitis. It should not be used in children having age less than 2 years.

Eucrisa/crisaborole Cost

Eucrisa is now avaiable in the market in two pack size 60g and 100g. Average cost of 1 tube (60g) of eucrisa with 2% potency ranges between 500$ - 800$. This price may variate with the passage of time so, make it confirm by visiting your nearby pharmacy before purchasing.

Intrarosa/prasterone Cost, Side effects, Dosage, Uses for intercourse Pain in Women

Intrarosa is marketed by Quebec-based Endoceutics Inc.

U.S. FDA approved a new product Intrarosa that contains active ingredient prasterone for the treatment of pain in postmenopausal women during sexual intercourse. This pain intensity might be moderate to severe and condition is known as dyspareunia. Intrarosa is first kind of this category approved by FDA. Prosterone is basically a steroidal hormone that produces naturally inside body ( endogenous Production). It is also know as Dehydroepiandrosterone (DHEA) and circulates in human body in large amounts. Prosterone plays many physiological role in the body like biosynthesis of sex hormones like estrogens and androgens.

Postmenopuasal problems are very common in women like flushing, mood swings, metabolic changes in the body and osteoporosis. According to research major underlying cause of intense pain during sexual intercourse in postmenopausal women is atrophy of internal membrane of vulva and vagina. It is proposed that this atrophy is triggered due to low levels of estrogen circulating in the body and vaginal tissues for a long time and condition is known as vulvar and vaginal atrophy (VVA).

Basic mechanism of Intrarosa (prasterone) is that it decreases the adrenal insufficiency in women but still exact pathway by which it works is not fully understood due to inadequate clinical data. According to FDA its efficacy was established after 12 week clinical trials and women who were taking intrarosa during these trials experienced remarkable decrease in the severity of pain.


Intrarosa/prasterone Side effects 

According to data obtained from clinical trials all side effects were minor to moderate. During these clinical trials no life threatening or lethal side effect was reported. Detail of these side effects is as follows

Minor Side effects

  • Headache
  • Irritation during insertion
  • Sense of discomfort in lower abdominal

Moderate Side effects

  • Vaginal Discharge
  • Abnormal Pap smear
  • Vaginal pain
  • Vaginal odor

Intrarosa/prasterone Uses or Prescribing Information

Though, prasterone is available in many dietary supplements but FDA approved only vaginal pessaries of prasterone to decrease the intensity of pain during intercourse in postmenopausal women. According to clinical trials intrarosa shows its therapeutic effect when used for specified period of time. Short term usage for few days does not produce significant effect.

Intrarosa/prasterone Dosage

Intrarosa is manufacturing in the form of vaginal insert tab or pessary. Each tab or pessary contains 6.5mg of prasterone for the treatment of moderate to severe dyspareunia caused by postmenopausal vulvar/vaginal atrophy. Standard dosage frequency of intrarosa in women is 1 vaginal insert daily at bedtime with the help of applicator.

Intrarosa/prasterone Cost

According to market survey this drug is currently not available at retail pharmacies because it is recently approved by FDA and is under manufacturing process. Once, it will be available at retail outlets we will let you know about the unit cost of drug and its dosage frequency.