Mvasi Cost, Side effects, Dosage, Uses for Cancer

Mvasi Cost, Side effects, Dosage, Uses for cancer. The FDA granted approval of Mvasi to Amgen, Inc. Avastin was approved in February 2004 and is manufactured by Genentech, Inc.

US FDA approved first biosimilar drug Mvasi/bevacizumab-awwb for the treatment of different kind of cancers. Mvasi is quite equal in efficacy to already present reference product Avastin (Genetech/Roche) which was approved by US FDA in 2004. Mvasi has same indications like the reference product Avastin (Genetech/Roche). Mvasi/bevacizumab-awwb major indications include colon cancer, non-small cell lung cancer, glioblastoma, ovarian cancer, breast cancer and renal cell carcinoma. US FDA approved this biosmilar drug on the basis of cost difference because biosimilars are expected to be cheaper but their safety profile, indications and adverse effects are quite similar to reference product.

Cancer is one of the leading cause of death across the globe. Some tumors are not metastatic and less dangerous as compared to other metastatic cancers. Each cancer might have different sign and symptoms as compared to other one but as a general some commonly observed symptoms of cancer are consistent weight loss, sweating during night time, bleeding, formation of lumps, changes in bowel movements. Some kind of viral infections may also lead to cancer if persist for a longer period of time.

Rigorous research is still on the way to find complete cure of cancer. Etiology of each cancer might be different but certain risk factors like genetic predisposition, exposure to radiations and chemicals, chronic viral infections, sedentary life style, obesity, smoking, alcoholism and environmental pollution play important role in its development.

Mvasi Cost, Side effects, Dosage, Uses for Cancer


Mvasi Side effects


Some commonly observed side effects during this drug therapy include
  • Bleeding or hemorrhage
  • Hypertension
  • Nasal cavity swelling
  • Loss of protein through urine
  • Rashes
  • Changes in mouth taste
  • Nausea
  • Vomiting
  • Abdominal Discomfort
  • Dryness of skin
  • Excessive lacrimation
  • Skin allergy

Mvasi Uses


US FDA approved Mvasi for the treatment of Metastatic colorectal cancer in combination with other drugs or as second line therapy, non-squamous non-small cell lung cancer, glioblastoma in aggressive stage, metastatic renal cell carcinoma and cervical cancer.

Mvasi Dosage


Metastatic colorectal cancer
  • 5 mg/kg IV every 2 weeks with bolus-IFL
  • 10 mg/kg IV every 2 weeks with FOLFOX4
  • 5 mg/kg IV every 2 weeks or 7.5 mg/kg IV every 3 weeks with
fluoropyrimidine-irinotecan or fluoropyrimidine-oxaliplatin based chemotherapy after progression on a first-line bevacizumab product containing regimen.

Non-squamous non-small cell lung cancer 
  • 15 mg/kg IV every 3 weeks with carboplatin/paclitaxel
 Glioblastoma
  • 10 mg/kg IV every 2 weeks
Metastatic renal cell carcinoma (mRCC)
  • 10 mg/kg IV every 2 weeks with interferon alfa Persistent, recurrent, or metastatic carcinoma of the cervix
  • 15 mg/kg IV every 3 weeks with paclitaxel/cisplatin or paclitaxel/topotecan 

Mvasi Cost 


Mvasi cost is difficult to evaluate at the moment as according to market survey this drug is currently not available at retail pharmacies because it is recently approved by FDA and is under manufacturing process. Once, it will be available at retail outlets we will let you know about the unit cost of drug and its dosage frequency.

Aliqopa/Copanlisib Cost, Side effects, Dosage, Uses for relapsed follicular lymphoma

Aliqopa/Copanlisib Cost, Side effects, Dosage, Uses for relapsed follicular lymphoma. The FDA granted the approval of Aliqopa to Bayer Healthcare Pharmaceuticals, Inc.

US FDA approved new drug Aliqopa that contains active pharmaceutical ingredient copanlisib for the treatment of recurrent or relapsed follicular lymphoma in adult patients. Aliqopa basically belongs to a class known as Class I phosphoinositide 3-kinase inhibitors. US FDA granted accelerated approval of Aliqopa due to its effective response rate.

Follicular lymphoma is a characterized as type of blood cancer in which body synthesize abnormal B lymohocytes that fight against infection and diseases. Abnormal B lymphocytes turned into lymphoma cells and builds up in lymph nodes. This is slow growing form of blood cancer and also categorized as non-Hodgkin lymphoma. Some commonly observed symptoms of follicular lymphoma are tenderness, consistent weight loss, sweating during night time, palpitations, low grade fever, generalized weakness and weak immunity.

Exact underlying cause of follicular lymphoma is not yet well understood. However, many researchers and scientists believe that genetic predisposition, continuous exposure to toxic chemicals, radiations, environmental factors and sedentary lifestyle are main leading causes of follicular lymphoma. Proper diagnosis can only be done via lymph nodes biopsy. Radioactive scans can also be used to
to diagnose follicular lymphoma.

Aliqopa/Copanlisib mechanism of action is that it inhibits proliferation of primary malignant B cell lines and causes death of tumor cells via apoptosis. Aliqopa/Copanlisib also blocks several pathways like  B-cell receptor (BCR) signaling that triggers proliferation of  lymphoma cells.

Aliqopa/Copanlisib Cost, Side effects, Dosage, Uses for relapsed follicular lymphoma

Aliqopa/Copanlisib Side effects


According to health authorities following side effects were noted during clinical trials of Aliqopa/Copanlisib.
  • Increase blood glucose levels
  • Diarrhea
  • Skin rashes
  • Generalized weakness
  • High blood pressure
  • Nausea
  • Vomiting
  • Anemia
  • Increase susceptibility to infection
  • neutropenia

Aliqopa/Copanlisib Uses or Prescribing Information


US FDA approved this drug for the treatment of  relapsed follicular lymphoma (FL) in adult patients who have received at least two prior systemic therapies. Withhold drug  in case of severe infection of hyperglycemia until they completely resolved.

Aliqopa/Copanlisib Dosage


Aliqopa/Copanlisib is formulated in the form of injection for parenteral administration in single dose vial containing 60 mg Aliqopa/Copanlisib as a lyophilized solid  for reconstitution. Standard dosage frequency of Aliqopa/Copanlisib is 60mg intravenously in 1 hour on first day of therapy then repeat it on day 8 and 15.


Aliqopa/Copanlisib Cost


Aliqopa/Copanlisib Cost is difficult to evaluate at the moment as according to market survey this drug is currently not available at retail pharmacies because it is recently approved by FDA and is under manufacturing process. Once, it will be available at retail outlets we will let you know about the unit cost of drug and its dosage frequency.

Benznidazole Cost, Side effects, Dosage, Uses for Chagas disease

Benznidazole Cost, Side effects, Dosage, Uses for Chagas disease. FDA granted approval of Benznidazole to Chemo Research, S.L.

US FDA approved new drug that that contains active pharmaceutical ingredient Benznidazole for the treatment of Chagas disease in pediatric patients having age 2 to 12 years. This is first kind of therapy approved by US FDA for the treatment of chagas in pediatric patients.

Chagas disease is also termed as American trypanosomiasis is a kind of rare tropical parasitic disease causes by parasite known as trypanosoma cruzi. Insects or bugs like triatominae are carriers of such parasite and when they bite or suck blood from human body this parasite gets enter into blood stream. Commonly observed symptoms are fever, swelling and enlargement of lymph nodes, body pain, headache and swelling in extremities.

This parasite may also cause infection in animals (mammals) if it enters into their blood stream. Other source of transmission of this disease are contaminated blood transfusion, transplantation of organ for carrier donor, eating food that contains such parasite and vertical transmission is also possible in case of chagas disease.

Benznidazole is anti-parasitic drug that belongs to a medicinal class known as nitroimidazole. It works by releasing radical species that binds with parasite DNA and damage it. This will decrease the proliferation parasite inside the blood and ultimately disease spread will be reduce.

Benznidazole Cost, Side effects, Dosage, Uses for Chagas disease


Benznidazole Side effects


According to health authorities following side effects were observed during clinical of this drug.

  • Abdominal Pain
  • Rash
  • Weight loss
  • Headache
  • Nausea
  • Vomiting
  • Neutropenia
  • Itching
  • Loss of appetite

Benznidazole Uses



US FDA approved benznidazole for the treatment of Chagas disease in pediatric patients having age 2 to 12 years.  Breastfeeding is not recommended during administration of benznidazole.  This drug may interact with disulfiram so, there must be a gap of 2 weeks between these two therapies to avoid undesirable effects.


Benznidazole Cost and Dosage


Benznidazole cost is difficult to evaluate at the moment as according to market survey this drug is currently not available at retail pharmacies because it is recently approved by FDA and is under manufacturing process. Once, it will be available at retail outlets we will let you know about the unit cost of drug and its dosage frequency.

Mylotarg Cost, Side effects, Dosage, Uses for acute myeloid leukemia

Mylotarg Cost, Side effects, Dosage, Uses for acute myeloid leukemia. The FDA granted the approval of Mylotarg to Pfizer Inc.

US FDA approved drug Mylotarg that contains active pharmaceutical ingredient gemtuzumab ozogamicin which is monoclonal antibody for the treatment of acute myeloid leukemia in CD33-positive AML patients. In past, this drug was voluntarily withdrawn from market in 2010 because the drug was failed to verify clinical benefits after subsequent confirmatory trials. The drug will be again in market after 7 years of absence following its approval by US FDA on September 1, 2017.

Acute myeloid leukemia (AML) is a kind of cancer that targets white blood cells. In this disease mutation occurs in specific genes due to which bone marrow produce abnormal and immature white blood cells that are physiologically non-functional. Onset of symptoms include mild to moderate fever, busing, asthenia (loss of energy), muscular pain. In later stages, internal hemorrhage may leads to bleeding inside the body. Proper diagnosis of can only done via blood tests or bone marrow biopsy.

Research is still underway to find out exact underlying cause that trigger mutations and mediates the pathophysiology this disease. Many scientists believe that certain factors like genetic predisposition, exposure to radiations and chemicals, smoking play important in the pathophysiology of disease. Some viral infections of bone marrow may also trigger such kind of disease if they persist for longer duration of time.

Mylotarg/Gentuzumab ozogamicin is a combination of humanized monoclonal antibody (Gentuzumab) specifically designed to bind with CD-33 and second drug is cytotoxic anti-tumor antibiotic calicheamicin. After administration it readily binds with CD-33 and then ozogamicin exerts its anti-tumor antibiotic effects.

Mylotarg Cost, Side effects, Dosage, Uses for acute myeloid leukemia

Mylotarg Side effects


According to health authorities this drug may exhibit following side effects after its administration
  • Pyrexia
  • Increase susceptibility to infections
  • Nausea
  • Vomiting
  • Elevated level of liver enzymes
  • Rashes
  • Swelling in extremities
  • Hypersensitivity
  • Mouth Ulcers
  • Hemorrhage
  • Blockage of the veins

Mylotarg Uses


US FDA approved Mylotarg for the treatment of for the treatment of acute myeloid leukemia in CD33-positive AML patients. The drug has also been approved for the treatment of CD33-positive AML in both pediatric and adult patients who have experienced a relapse or who have not responded to initial treatment.

Mylotarg Dosage


Mylotarg is formulated as single dose vial that contains 4.5mg lyophilized cake powder for reconstitution. Standard dosage frequency of Mylotarg is  3 mg/m2 (up to one 4.5 mg vial) on Days 1, 4, and 7 in combination with daunorubicin.

Mylotarg Cost


Mylotarg cost is difficult to evaluate at the moment as according to market survey this drug is currently not available at retail pharmacies and is under manufacturing process. Once, it will be available at retail outlets we will let you know about the unit cost of drug.

Duzallo Cost, Side effects, Dosage, Uses for Gout

Duzallo Cost, Side effects, Dosage, Uses for Gout. US FDA granted approval of Duzallo to Ardea Biosciences, Inc.

US FDA approved new drug Duzallo that is fixed dose combination of two active pharmaceutical ingredients namely lesinurad and allopurinol for the treatment of elevated uric acid level (hyperuricemia) associated with gout who are not responding to daily dose of allopurinol alone. This is the first drug approved by US FDA that contains such combination for the treatment of gout. However, Duzallo is not recommended for the treatment of asymptomatic hyperuricemia.

Gout is an inflammatory disease associated with elevated levels of uric acid in the blood that deposits in the form of crystals around joints and bones and causes intense pain. Affected joints become tender, red, hot and inflamed. Most commonly affected areas are toes, hands, knees etc. The exact cause of elevation of uric acid is unknown but many researchers believe that genetic predisposition and dietary factors play important role in the pathophysiology of gout. It is common disease that usually affects people in middle or later ages. Historically, it is known as disease of kings or rich man's disease.

Incidence of disease can be minimized by changing your life style e.g doing regular exercise, eating food that does not produce uric acid as a by product in the body, avoid smoking and alcohol consumption, control over obesity and consuming vitamin C through natural origin.

Duzallo contains two active pharmaceutical ingredients e.g lesinurad that inhibits uric acid readsorption and allopurinol that is  xanthine oxidase inhibitor. So, Duzallo works by increasing excretion and inhibiting production of uric acid. Duzallo provides better control over uric acid in those people who are not responding to allopurinol alone.

Duzallo Cost, Side effects, Dosage, Uses for Gout


Duzallo Side effects


According to health authorities following side effects can expected during therapy depending upon patient overall health, age and genetic predispositions.

  • Renal Impairment
  • Hypersensitivity reactions
  • Hepatotoxicity
  • Cardiovascular events
  • Bone Marrow  suppression
  • Increased level of creatinine
  • Gastro-esophageal reflux disease
  • Rashes
  • Headache
  • Nausea
  • Vomiting
  • Abdominal Discomfort
  • Bloating

Duzallo Uses/Patient Information


US FDA approved Duzallo for the treatment of elevated uric acid level (hyperuricemia) associated with gout who are not responding to daily dose of allopurinol alone. Duzallo is not recommended for the treatment of asymptomatic hyperuricemia.

Duzallo Dosage


Dozallo will be available for oral administration in the form of tablets. However, standard dosage frequency of Duzallo is 1 tablet per day that contains 200mg lesinurad and 300mg allopurinol. However, dose adjustment should be kept under consideration in case of toxicity or renal impairment.

Duzallo Cost


According to market survey this drug is currently not available at retail pharmacies because it is recently approved by FDA and is under manufacturing process. Once, it will be available at retail outlets we will let you know about the unit cost of drug and its dosage frequency.

Cyltezo Cost, Side effects, Dosage, Uses for multiple indications

Cyltezo Cost, Side effects, Dosage, Uses for multiple indications. FDA granted approval of Cyltezo to Boehringer Ingelheim Pharmaceuticals, Inc.

US FDA approved second biosimilar drug Cyltezo that contains adalimumab-adbm for multiple indications. This is the second biosmilar drug approved by US FDA after the approval of Amjevita to Amgen, Inc. Cyltezo is approved for multiple indications realted to rheumatology like Crohn's disease, rheumatoid arthritis, ulcerative colitis, ankylosing spondylitis and plaque psoriasis etc. A biosimilar also termed as follow-on biologic or subsequent entry biologic is a medicinal product that is almost identical copy of original product manufactured by different company.

Cyltezo/adalimumab-adbm works by inhibiting tumor necrosis factor (TNF) via bing with tumor necrosis factor-alpha (TNFα). Normally, tumor necrosis factor-alpha (TNFα) binds with TNFα receptors to initiate inflammatory response triggered by autoimmune disease But after the administration of Cyltezo/adalimumab-adbm through subcutaneous route (SC) it readily binds with tumor necrosis factor-alpha (TNFα) and restricts its binding with TNFα receptors. This will cause a reduction in inflammatory response mediated by auto-immune disease.

Cyltezo/adalimumab-adbm is also approved for the treatment of moderately to severely active poly-articular juvenile idiopathic arthritis in children having age 4 years or more.  According to US FDA, a biosimilar is very close to already approved reference product in terms of clinical effectiveness and safety profile. The only difference that can be expected or allowable is modification in inactive pharmaceutical ingredients that does not pose any change in effectiveness of the drug.

Cyltezo Cost, Side effects, Dosage, Uses for multiple indications


 Cyltezo Side effects


According to health authorities following side effects can be expected during the therapy depending upon the factors like patient age, history and genetic predispositions.
  • Increase susceptibility to infections (RTI) 
  • Reaction at injection site
  • Rashes
  • Headache
  • Anaphylaxis or serious allergic reactions
  • Malignancies
  • Lupus-like syndrome
  • Demyelinating disease
  • Cardiovascular problems
  • Cytopenias
 

    Cyltezo Uses/Patient Information


    US FDA approved this drug for multiple indications like  Crohn's disease, rheumatoid arthritis, ulcerative colitis, ankylosing spondylitis and plaque psoriasis etc. Additionally, it is also approved for the treatment of moderately to severely active poly-articular juvenile idiopathic arthritis in children having age 4 years or more.

    Cyltezo Dosage


    Cyltezo is will be availabe in parenteral dosage form for administration through subcutaneous route. Dosage frequency of Cyltezo is 40 mg subcutaneously every other week in case of rheumatoid arthritis, psoriatic arthritis or ankylosing spondylitis. Similarly, in case of plaque psoriasis dosage frequency will be 80mg as initial dose and then 40 mg subcutaneously every other week.

    Cyltezo Cost


    According to market survey this drug is currently not available at retail pharmacies because it is recently approved by FDA and is under manufacturing process. Once, it will be available at retail outlets we will let you know about the unit cost of drug and its dosage frequency.

    Besponsa/inotuzumab Cost, Side effects, Dosage, Uses for acute lymphoblastic leukemia

    Read about Besponsa/inotuzumab Cost, Side effects, Dosage, Uses for acute lymphoblastic leukemia. The FDA granted the approval of Besponsa to Pfizer Inc.

    US FDA approved new drug Besponsa that contains active pharmaceutical ingredient inotuzumab ozogamicin for the treatment of recurring acute lymphoblastic leukemia (ALL) in adult patients. Besponsa is targeted therapy for acute lymphoblastic leukemia and FDA categorized besponsa as breakthrough therapy.

    Acute lymphoblastic leukemia is characterized by over proliferation abnormal and immature white blood cells. Leukocytes are also termed as white blood cells so, this disease is also known as white blood cells cancer. Prevalence rate of acute lymphoblastic leukemia remains high in childhood and old age especially after 50's. White blood cells are produce by bone marrow but due to abnormality in genetic makeup immature and abnormal white blood cells produce that inhibits production of normal leukocytes and spread to other organs of body.

    Symptoms associated with acute lymphoblastic leukemia include limited or no production of normal leukocytes, fever, more susceptibility towards infections, chills, shortness of breath, chest pain, nausea, vomiting, headache and weakness. Unfortunately, these symptoms usually develop in late stages or when the disease progressed more than 50%. At the beginning of disease patient do not feel any significant symptom due to which it becomes difficult to identify it. Survival and prognosis is strongly depends upon stage at which it is identified.

    Research is still in process to identify exact reason leukemia but many scientist believe that children who have family history of such events are more prone to this deadly disease due to vulnerability present in their genetic make-up. Besponsa contains Inotuzumab that is monoclonal antibody utilized to bind with CD22 and ozogamicin that is cytotoxic agent belongs to a class termed as calicheamicins.

    Besponsainotuzumab Cost, Side effects, Dosage, Uses for acute lymphoblastic leukemia


    Besponsa/inotuzumab Side effects


    According to data provided by health authorities drug exhibit following side effects during clinical trials.

    • Thrombocytopenia (Decrase in platelets)
    • Leukopenia (Decrease in white blood cells)
    • Headache
    • Fatigue
    • Hemorrhage
    • Body swelling
    • Abdominal Discomfort
    • Hyperbilirubinemia
    • Elevated level of liver enzymes

    Besponsa/inotuzumab Uses/Prescribing information


    US FDA approved besponsa for the treatment of refractory acute lymphoblastic leukemia in adults. US FDA categorized beponsa as a breakthrough therapy.

    Besponsa/inotuzumab Dosage


    Besponsa is formulated as lyophilized powder for reconstitution in a single use vial. One vial of besponsa contains 0.9mg of drug. However, dosage frequency of besponsa is 0.8mg/m2 at first day of therapy then 0.5mg/m2 at 8th and 15th day. This is first cycle of drug administration in which
    in total 1.8mg/m2 drug is administered in three divided doses. Similarly, in subsequent cycles total dose that is adminitered is 1.5mg/m2 in three divided doses.  

    Besponsa/inotuzumab Cost


    This drug is administered by your healthcare practitioner (HCP), which usually means:
    • It may comes under special items category.
    • You cannot fill this prescription in a regular pharmacy. Your doctor, hospital, or clinic will provide this  medication because of possible complications or other issues.
    • This drug is likely to be covered under your medical benefit if you have insurance.

    Mavyret Cost, Side effects, Dosage, Uses for Hepatitis C

    Mavyret Cost, Side effects, Dosage, Uses for Hepatitis C. The FDA granted approval of Mavyret to AbbVie Inc.

    US FDA approved new drug  Mavyret that contains combination of drugs for the treatment of chronic hepatitis C without cirrhosis or with mild cirhosis. Mavyret contains 2 kind of drugs that include glecaprevir in 100mg strength and pibrentasvir in 40mg strength. Mavyret is indicated for the treatent of chronic hepatitis c having genotype 1 to 6.

    Hepatitis C is characterized as chronic infection caused by virus that belongs to virus family Flaviviridae. Virus of Hepatitis C is single stranded RNA virus having 7 different kinds of genotypes 1 to 7. Genotypes that have high prevalence rate are 1,2,3 and 4. At beginning of disease patient have minute or low intensity symptoms like dark urine, yellowish tinged color skin, mild pain in abdomen and mild fever,

    Transmission of hepatitis C virus mainly occurs via blood to blood contact in the form of contaminated nail cutters, tooth brush, syringes, razors, needles, piercing equipments etc. Contaminated blood transfusion is another leading cause that spreads hepatitis C. Cases of vertical transmission (spread through an infected mother to her baby during birth) of hepatitis c are consistently increasing in USA.

    Unfortunately, during early stages virus silently kills hepatocytes and patient remains unaware of such damage but after 60% to 70% damage of liver symptoms become sever and intense. So far, there is no vaccine for hepatitis c due to diversity in genotype of hepatitis c virus. In later stages, patient usually feels symptoms like fever, blood in vomit or tool, loss of appetite, fatigue, nausea, muscle and weakness. At cirrhosis stage liver becomes inflamed and it causes internal hemorrhaging, portal hypertension and ascites.

    Mavyret shows promising results during clinical trials but treatment duration with Mavyret depends upon number of factor like treatment history, viral genotype, and cirrhosis status.



    Mavyret Side effects


    According to health authorities following side effects were observed during clinical trials of Mavyret.
    • Headache
    • Fatigue
    • Nausea
    • Vomiting
    • Muscle weakness
    • Abdominal discomfort
    • Mild Fever

    Mavyret Uses


    US FDA approved Mavyret for the treatment of  chronic hepatitis C without cirrhosis or with mild cirhosis. Mavyret is indicated for the treatment of chronic hepatitis having genotype 1 to 6. In case of advance cirrhosis of severe cirrhosis this drug should be avoided.

    Mavyret Dosage


    Mavyret contains 2 kind of drugs that include glecaprevir in 100mg strength and pibrentasvir in 40mg strength. In adults, standard dosing frequency of Mavyret is 3 tablets per day with food for 8 weeks. Dose titration must be considered in case of liver or hepatic impairment.

    Mavyret Cost


    According to market survey this drug is currently not available at retail pharmacies because it is recently approved by FDA and is under manufacturing process. Once, it will be available at retail outlets we will let you know about the unit cost of drug and its dosage frequency.

    Idhifa/enasidenib Cost, Side effects, Dosage, Uses for acute myeloid leukemia

    Read about Idhifa/enasidenib Cost, Side effects, Dosage, Uses for acute myeloid leukemia.The FDA granted the approval of Idhifa to Celgene Corporation

    US FDA approved new drug idhifa that contains active pharmaceutical ingredient enasidenib for the treatment of acute myeloid leukemia (AML) in adult patients who have relapsed of AML due to mutation in specific gene. US FDA indicated this drug along with specific assay to identify mutations IDH2 gene before initiating specific therapy.

    Leukemia is a group of cancers that usually affect bone marrow. All types of leukemia tend to increase immature white blood cells. Research is still in process to find out exact underlying cause of leukemia but many researchers believe that genetic predisposition and environmental factors are key factors in the pathogenesis of leukemia. These factors include continuous exposure to certain toxic
    chemicals in plants and factories, exposure to radiations, smoking, viral infections etc.

    There are four major types of leukemia commonly identified in patients. These are acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), chronic lymphocytic leukemia (CLL) and chronic myeloid leukemia (CML). Survival rate of leukemia mainly depends upon patient age and type leukemia.  

    Idhifa/enasidenib is IDH-2 (isocitrate dehydrogenase-2) inhibitor that blocks enzymes responsible proliferation of immature white blood cells in case of acute myeloid leukemia. This drug must be used in case of detection of IDH2 gene mutations via RealTime IDH2 Assay.


    Idhifa/enasidenib Cost, Side effects, Dosage, Uses for acute myeloid leukemia


    Idhifa/enasidenib side effects


    According to health authorities following side effects were reported during clinical trails

    • Fever
    • Difficulty in breathing
    • Acute respiratory distress
    • Inflammation in lungs
    • Fluid accumulation in lungs
    • Weight gain
    • Metabolic changes
    • Swelling
    • Abdominal pain
    • hepatic and renal impairment


    Idhifa/enasidenib Uses


    US FDA indicated Idhifa/enasidenib for the treatment of acute myeloid leukemia (AML) in adult patients who have relapsed of AML due to mutation in specific gene. US FDA indicated this drug along with specific assay to identify mutations IDH2 gene before initiating specific therapy.

    Idhifa/enasidenib Dosage

    This drug is formulated as tablet form in two potencies 50mg and 100mg. Standard dosing frequency for adult patients is 100mg orally with or without food for up-to 6 months to see significant clinical response. In case of toxicity discontinue drug and consult with your health care provider.

    Idhifa/enasidenib Cost 


    Idhifa is now available in market with average cost of 25,400$ to 26,700$ per pack (30's) of 50mg tablets.This cost may variate with the passage of time so, make it confirm by visiting your nearby pharmacy before purchasing.

    Nerlynx/neratinib Cost, Side effects, Dosage, Uses for breast cancer

    Nerlynx/neratinib Cost, Side effects, Dosage, Uses for breast cancer. The FDA granted approval of Nerlynx to Puma Biotechnology, Inc

    US FDA approved new drug Nerlynx that contains neratinib as active pharmaceutical ingredient as extended adjuvant treatment of early-stage, HER2-positive breast cancer. This is first kind of therapy approved by FDA as an adjuvant treatment along with primary treatment ( trastuzumab therapy) to reduce the risk of breast cancer recurrence.

    Breast cancer is one of the leading cause of death in females due to cancer. Initially, it appears as a lump inside the breast that growth with the passage of time and reaches to progressive metastatic stage. There are no obvious symptoms at initial stages that makes it hard to diagnose earlier. Later on patient may feel bone pain, swollen lymph nodes, fatigue, shortness of breath and mild fever in some cases also been reported.

    Exact underlying mechanism that causes breast cancer is sill not yet clear to somehow but some important risk factors that play important role in pathophysiology of breast cancer are obesity, alcohol consumption, smoking, HRT (hormone replacement therapy), early menopause and family history more specifically.
    People having cases of breast cancer in their family history especially inherited mutations in gene BRCA1 and BRCA2 have high risk of developing breast cancer in their later ages. So, regular screening for breast cancer in very beneficial for such candidates.

    Nerlynx/neratinib belongs to a therapeutic class termed as tyrosine kinase inhibitors. Pharmacologically, it binds with side chain of cysteine and inhibits epidermal growth factor receptor and human epidermal growth factor 2. Nerlynx/neratinib is used as adjuvant treatment along with primary treatment to decrease the cancer progression and its recurrence.

    Nerlynx/neratinib Cost, Side effects, Dosage, Uses for breast cancer

    Nerlynx/neratinib Side effects


    According to health authorities following side effects were observed during its clinical trials

    • Fatigue
    • Headache
    • Nausea
    • Vomiting
    • Diarrhea
    • Abdominal Pain
    • Loss of appetite
    • Swelling of mucosa
    • Muscular weakness and spasm
    • Increase in liver enzymes
    • Weight loss
    • UT's
    • Skin rashes
    • Hypersensitivity reaction

    Nerlynx/neratinib Uses/Prescribing Information


     US FDA indicated this drug as extended adjuvant treatment of early-stage, HER2-positive breast cancer. It is used to reduce the progression of diseases as well as cancer recurrence. This is first kind of therapy approved US FDA as extended adjuvant therapy for the treatment of breast cancer.

    Nerlynx/neratinib Dosage


    This drug is formulated as tablet for oral administration with potency of 40mg. However, standard dosage frequency of this drug is 240mg orally with food daily for one year. In case of renal or hepatic impairment dose titration should be considered or in case of toxicity it's administration should be discontinued.

    Nerlynx/neratinib Cost/Price

    Nerlynx is now available in market with average cost of 1700$ to 1800$ per pack (30's). This cost may variate with the passage of time so, make it confirm by visiting your nearby pharmacy before purchasing.