Nerlynx/neratinib Cost, Side effects, Dosage, Uses for breast cancer

Nerlynx/neratinib Cost, Side effects, Dosage, Uses for breast cancer. The FDA granted approval of Nerlynx to Puma Biotechnology, Inc

US FDA approved new drug Nerlynx that contains neratinib as active pharmaceutical ingredient as extended adjuvant treatment of early-stage, HER2-positive breast cancer. This is first kind of therapy approved by FDA as an adjuvant treatment along with primary treatment ( trastuzumab therapy) to reduce the risk of breast cancer recurrence.

Breast cancer is one of the leading cause of death in females due to cancer. Initially, it appears as a lump inside the breast that growth with the passage of time and reaches to progressive metastatic stage. There are no obvious symptoms at initial stages that makes it hard to diagnose earlier. Later on patient may feel bone pain, swollen lymph nodes, fatigue, shortness of breath and mild fever in some cases also been reported.

Exact underlying mechanism that causes breast cancer is sill not yet clear to somehow but some important risk factors that play important role in pathophysiology of breast cancer are obesity, alcohol consumption, smoking, HRT (hormone replacement therapy), early menopause and family history more specifically.
People having cases of breast cancer in their family history especially inherited mutations in gene BRCA1 and BRCA2 have high risk of developing breast cancer in their later ages. So, regular screening for breast cancer in very beneficial for such candidates.

Nerlynx/neratinib belongs to a therapeutic class termed as tyrosine kinase inhibitors. Pharmacologically, it binds with side chain of cysteine and inhibits epidermal growth factor receptor and human epidermal growth factor 2. Nerlynx/neratinib is used as adjuvant treatment along with primary treatment to decrease the cancer progression and its recurrence.

Nerlynx/neratinib Cost, Side effects, Dosage, Uses for breast cancer

Nerlynx/neratinib Side effects


According to health authorities following side effects were observed during its clinical trials

  • Fatigue
  • Headache
  • Nausea
  • Vomiting
  • Diarrhea
  • Abdominal Pain
  • Loss of appetite
  • Swelling of mucosa
  • Muscular weakness and spasm
  • Increase in liver enzymes
  • Weight loss
  • UT's
  • Skin rashes
  • Hypersensitivity reaction

Nerlynx/neratinib Uses/Prescribing Information


 US FDA indicated this drug as extended adjuvant treatment of early-stage, HER2-positive breast cancer. It is used to reduce the progression of diseases as well as cancer recurrence. This is first kind of therapy approved US FDA as extended adjuvant therapy for the treatment of breast cancer.

Nerlynx/neratinib Dosage


This drug is formulated as tablet for oral administration with potency of 40mg. However, standard dosage frequency of this drug is 240mg orally with food daily for one year. In case of renal or hepatic impairment dose titration should be considered or in case of toxicity it's administration should be discontinued.

Nerlynx/neratinib Cost/Price


According to market survey this drug is currently not available at retail pharmacies because it is recently approved by FDA and is under manufacturing process. Once, it will be available at retail outlets we will let you know about the unit cost of drug and its dosage frequency.

Vosevi Cost, Side effects, Dosage, Uses for Hepatitis C

Vosevi Cost, Side effects, Dosage, Uses for Hepatitis C. The FDA granted approval of Vosevi to Gilead Sciences Inc.

US FDA approved new drug  Vosevi that contains combination of drug as a fixed dose for the treatment of chronic hepatitis C without cirrhosis or with mild cirhosis.Vosevi contains 3 kind of drugs that include sofosbuvir in 400mg strength which is NS5B inhibitor, Velpatasvir in 100mg which is  NS5A inhibitor and voxilaprevir in 100mg strength which is NS3/4A inhibitor. Vosevi is administered as once daily dose of combined therapy (fixed dose).

Hepatitis C is a viral infection caused by virus family Flaviviridae. Hepatitis C virus is single stranded RNA virus with seven genotypes starting from 1 to 7. Most commonly occurring genotypes are 1,2,3 and 4. At early stages patient have no or insignificant symptoms like mild pain in abdomen,
mild fever, dark urine and yellowish tinged color skin.

Hepatitis C virus spreads via blood to blood contact in the form of contaminated syringes, razors, needles, nail cutters, tooth brush, piercing equipment etc. Blood transfusion (contaminated blood) is another way of transferring HCV from one person to another. Vertical transmission is also possible in case of hepatitis C for example it can spread through an infected mother to her baby during birth.

Unfortunately, patient feels no symptoms at early stages and when diseases enters into progressive stage it becomes difficult to treat. So far, there is no vaccine for hepatitis c due to diversity in genotype of hepatitis c virus. In later stages, symptoms become more prominent like loss of appetite,
fatigue, nausea, muscle weakness, fever, blood in vomit and stool. At cirrhosis stage liver becomes inflamed and it causes internal hemorrhaging, portal hypertension and ascites.

During clinical trails Vosevi showed promising results. Those patients who were taking Vosevi had no virus in their blood after 12 weeks of therapy. During clinical trails this drug decrease viral load effectively in variety of patients having genotype one to six.

Vosevi Cost, Side effects, Dosage, Uses for Hepatitis C


Vosevi Side effects

According to health authorities Vosevi exhibit following side effects during clinical trials

  • Headache
  • Cough
  • Fatigue
  • Diarrhea
  • Nausea
  • Vomiting
  • Mild fever
  • Abdominal Bloating
  • Muscular pain

Vosevi Uses/Patient information


US FDA indicated this drug for the treatment of  chronic hepatitis C without cirrhosis or with mild cirrhosis in adults patients having virus genotype 1-6. Patient taking rifampin must not be used this drug because it usage is contraindicated during rifampin therapy.

Vosevi Dosage

Vosevi contains 3 kind of drugs that include sofosbuvir in 400mg strength which is NS5B inhibitor, Velpatasvir in 100mg which is  NS5A inhibitor and voxilaprevir in 100mg strength which is NS3/4A inhibitor. Vosevi is administered as once daily dose of combined therapy (fixed dose).

Vosevi Cost/Price

According to market survey this drug is currently not available at retail pharmacies because it is recently approved by FDA and is under manufacturing process. Once, it will be available at retail outlets we will let you know about the unit cost of drug and its dosage frequency.

Tremfya/guselkumab Cost, Side effects, Dosage, Uses for Plaque Psoriasis

Tremfya/guselkumab Cost, Side effects, Dosage, Uses for Plaque Psoriasis. The FDA granted the approval of Tremfya to Janssen Biotech, Inc.

US FDA approved a new drug Tremfya that contains guselkumab for the treatment of plaque psoriasis in adult patients. Tremfya/guselkumab belongs to a group of class known as monoclonal antibodies. Psoriasis is basically autoimmune disease characterized as red scaly appearance of patches on skin. Pathologically, psoriasis is classified into 5 different types


  • Erythrodermic psoriasis
  • Inverse psoriasis
  • Plaque psoriasis
  • Guttate psoriasis
  • Pustular psoriasis


Genetic predisposition is major cause of psoriasis and symptoms may aggravate with environmental factors like winter season  or dry weather condition. Similarly, skin infection, psychological stress, drug side effects and diet poor in essential nutrients play important role in the pathogenesis of psorisis. It is a common belief that psorisis is contagious disease but according scientific approach this is not contagious disease because it is connected with exaggerated response of immune system.

Plaque psoriasis is also known as psoriasis vulgaris. It is most common form of psoriasis and globally about 70%-80% cases of psoriasis are associated with plaque psoriasis. Areas that are highly sensitive to plaque psoriasis are knees, scalp, back and elbows. Initially, it appears as silver white scales
on skin which become inflammed with the passage of time. In advance stage patient feels severe itching, swelling of affected areas, pain and inflammation of skin.

Tremfya/guselkumab is inhibits inflammatory responses produced by immune system that play important in the pathology of plaque psoriasis. Tremfya/guselkumab blocks release of inflammatory mediators like interleukin, chemokines and cytokines. According to FDA recommendations this therapy should be reserved for those patients who are not responding to conventional treatment and they are candidates for photo-therapy.

Tremfyaguselkumab Cost, Side effects, Dosage, Uses for Plaque Psoriasis

Tremfya/guselkumab Side effects


According to health authorities following side effects were observed during clinical trials.


  • Increase risk of infections like tuberculosis
  • Headache
  • Arthralgia
  • Asthenia
  • Gastroentritis
  • Reaction of injection site
  • Hypersensitivity
  • Diarrhea

Tremfya/guselkumab Uses/Patient Information

US FDA Tremfya for the treatment of adult patients with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy. At the moment, there not enough data over its usage in pregnancy. However, human antibodies are known to cross placental barrier. 

Tremfya/guselkumab Dosage

Tremfya/guselkumab is formulated as pre-filled syringe of 100mg/ml. However, it's dosage frequency is 100mg administered subcutaneously at start of therapy then second dose will be administered after 4 weeks. Now, after second dose all subsequent doses will be administered after every 8 weeks interval.    

Tremfya/guselkumab Cost/Price


According to market survey this drug is currently not available at retail pharmacies because it is recently approved by FDA and is under manufacturing process. Once, it will be available at retail outlets we will let you know about the unit cost of drug and its dosage frequency.

Endari Cost, Side effects, Dosage, Uses for sickle cell disease

Read about Endari Cost, Side effects, Dosage, Uses for sickle cell disease. The FDA granted the approval of Endari to Emmaus Medical Inc.

US FDA approved a new drug Endari that contains L-glutamine for oral administration for the treatment of sickle cell disease in patients having age 5 years or more. Sickle cell disease is a severe kind of hematological disorder. Endari is first kind of drug approved by US FDA to reduce complications and severity of symptoms associated with sickle cell disease.

Sickle cell disease is characterized as a group of hematological disorders that occur due to genetic mutations. Most commonly occurring form of sickle cell disease is sickle-cell anemia (SCA) in which patient have abnormal shaped RBC's that are either immature or non-function. Basic reason behind sickle cell anemia is mutation of hemoglobin that carries oxygen and supplies it to tissues of  whole body.

Symptoms associated with sickle cell disease are anemia, swelling of extremities, increase susceptibility to infection, hypoxia, acute chest syndrome, haemolytic crisis and moderate to severe pain. Patient having sickle cell disease must be vaccinated properly to minimize chances of common infection. Moreover, patient should be nourished well and remain hydrated. Supplements that contain high amount folic acid are also beneficial because folic is required for production of RBC's.

According to data provided by health authorities it has been observed that patients receiving Endari have less complications as compared to patients who were taking placebo. Similarly, patients receiving Endari have experienced fewer hospital visits for pain treatment.

Endari Cost, Side effects, Dosage, Uses for sickle cell disease


Endari Side effects


During clinical trial following side effects were observed induced by Endari.

  • Abdominal Pain
  • Constipation
  • Headache
  • Cough
  • Nausea
  • Vomiting
  • Chest pain
  • Extremities pain
  • Abdominal Bloating

Endari Uses/Patient Information


This is first drug approved by US FDA to reduce complications associated with sickle cell disease like body pain, chest pain, hypoxia etc.  US FDA approved this drug for patient having age 5 years or more.  Endari is administered via oral route in the form of powder.


 Endari Dosage


Enadri is formulated as powder for oral administration with potency of 5g L-glutamine/packet. However, it's dosage frequency for those who have body weight less than 30Kg is 5g L-glutamine powder orally two times a day. For those who have 30-65Kg weight dose will be 10g L-glutamine powder orally twice a day. Similarly, for those who have weight 65Kg or above dose will be 10g L-glutamine powder orally twice a day.

Endari Cost/Price


According to market survey this drug is currently not available at retail pharmacies because it is recently approved by FDA and is under manufacturing process. Once, it will be available at retail outlets we will let you know about the unit cost of drug and its dosage frequency.

Baxdela/delafloxacin Cost, Side effects, Dosage, Uses

Baxdela/delafloxacin Cost, Side effects, Dosage, Uses. The FDA granted approval of Baxdela to Melinta Therapeutics, Inc.

US FDA approved new drug Baxdela that contains delafloxacin as an active pharmaceutical ingredient for the treatment of Acute Bacterial Skin and Skin Structure Infections (ABSSSI). US FDA also indicated that this drug should only be used when there is no suitable option left behind because delafloxacin therapy is associated with tendon rupture, neuropathy and impaired cartilage growth.

Acute bacterial skin and skin structure infection (ABSSSI) is also know as soft tissue infection such as infection of connective tissues, mucous membrane and cartilage. Some commonly know soft tissue infections are abscesses, cellulitis, furuncles and impetiginous lesions. It has been observed that  Staphylococcus aureus and Streptococcus pyogenes are main causative agents for number skin soft tissue infections. In most instances, these infection can not cure via traditional antibiotics due to emergence of resistance.

Complicated type of skin infections include ulcers, gangrene and burns. They may become difficult to treat if they spread to internal layers of skin or reach to systemic circulation. Therefore, ration use of antibiotics is very necessary to mitigate the risk of resistance, secondary infection and to avoid further complications as well.

Baxdela/delafloxacin belongs to a pharmacological class termed as fluoroquinolones that inhibit replication of bacterial DNA. It has been observed during clinical trials that delafloxacin is more active than other agents belongs to this group of antibiotics. Main advantage of delafloxacin over other antibiotics of this group is that it readily deposits inside the bacteria and exerts potent bactericidal activity. 


Baxdela/delafloxacin Cost, Side effects, Dosage, Uses

Baxdela/delafloxacin Side effects


According to health authorities this drug exhibit following side effects during clinical trials

  • Nausea
  • Vomiting
  • Rashes
  • Headache
  • Diarrhea
  • Elevated liver enzymes
  • Gastrointestinal discomfort
  • Bloating
  • Hypersensitivity reactions
  • Neuropathy
  • Tendinitis

Baxdela/delafloxacin Uses/Patient Information


US FDA approved this drug for the treatment of acute Bacterial Skin and Skin Structure Infections
(ABSSSI). FDA also indicated that this drug should be used cautiously because it may cause neuropathy, tendinitis or CNS related problems.

Baxdela/delafloxacin Dosage


Baxdela is formulated in two types of dosage forms. One is oral dosage form with potency of 450mg per tablet and second is parenteral dosage form with potency of 300mg per vial. However, standard dosage frequency of Baxdela/delafloxacin is 450mg orally after every 12hrs for 7 to 14 days or 300mg intravenously after every 12hrs for 5-14 days for the treatment of Acute Bacterial Skin and Skin Structure Infections (ABSSSI). In case of renal or hepatic impairment dose titration should be kept in consideration.

Baxdela/delafloxacin Cost/Price


According to market survey this drug is currently not available at retail pharmacies because it is recently approved by FDA and is under manufacturing process. Once, it will be available at retail outlets we will let you know about the unit cost of drug and its dosage frequency.

Bevyxxa/betrixaban Cost, Side effects, Dosage, Uses for Venous thromboembolism

Bevyxxa/betrixaban Cost, Side effects, Dosage, Uses for Venous thromboembolism. The FDA granted approval of Bevyxxa to Portola Pharmaceuticals, Inc.

US FDA approved new drug Bevyxxa that contains betrixaban (factor Xa inhibitor) for the prophylactic treatment of venous thromboembolism in those adults who are hospitalized due to acute illness and have risk of thromboembolic phenomenon. FDA also indicated that this drug must not used in patients who are getting epidural anesthesia because it may increase the risk of epidural hematoma during spinal puncture.

venous thromboembolism is very common in bedridden patient especially those who are diabetics. When blood clots dislocate from its primary place and attached to lungs then it is termed as pulmonary embolism. Dislocated clots are very dangerous as they travel inside venous system and can cause blockage of blood circulation towards brain, heart or lungs.

Some risk factors that increase the chances of venous thromboembolism are orthopedic surgeries, older age, pregnancy, trauma, lack of activity for a long time and oral contraceptives. Genetic predisposition and blood disorders are also important in the pathophysiology of venous thromboembolism.

Betrixaban is basically an anticoagulant that inhibits factor Xa directly by binding with it. It has great affinity for factor Xa that's why it has shown promising results in clinical trials. It has also been observed that this drug is very useful for prevention of stroke and atrial fibrillation.



Bevyxxa/betrixaban Cost, Side effects, Dosage, Uses for Venous thromboembolism


Bevyxxa/betrixaban Side effects


According to health authorities drug exhibit following side effects during clinical trials.
  • Increase tendency of bleeding
  • Internal hemorrhage
  • Hypersensitivity reaction
  • Headache
  • Nausea
  • Gastrointestinal discomfort
  • Palpitation
  • Vomit like feeling
  • Abdominal distension

Bevyxxa/betrixaban Uses/Patient Information


US FDA approved this drug for prophylaxis or prevention of venous thromboembolism (VTE) in hospitalized patient due to acute illness because they have higher risk of venous thromboembolism as compared to those who are not bedridden. US FDA also warns that this drug must not be used in those patients who are undergoing for epidural anesthesia due to chances of spinal hematoma.

Bevyxxa/betrixaban Cost and Dosage


Bevyxxa is formulated in the form of oral dosage form (capsules) with potency of 40mg or 80mg per capsule. However, standard dosage frequency of Bevyxxa/betrixaban is 160mg orally for the first dose and 80mg orally for subsequent doses for the prophylaxis of Venous Thromboembolism. Dose titration should be considered in case of renal or hepatic impairment or Concomitant administartion of P-gp inhibitors.

Bevyxxa/betrixaban Cost/Price


US FDA approved this drug in oral dosage form. According to market survey this drug is currently not available at retail pharmacies because it is recently approved by FDA and is under manufacturing process. Once, it will be available at retail outlets we will let you know about the unit cost of drug and its dosage frequency.

Haegarda Cost, Side effects, Dosage, Uses for Hereditary Angioedema

Haegarda Cost, Side effects, Dosage, Uses for Hereditary Angioedema. The FDA granted approval of Haegarda to CSL Behring LLC.

US FDA approved new drug Haegarda for the treatment of rare kind of genetic disorder termed as hereditary angioedema. FDA approved indicated that this drug should be used in adolescent and adults for the treatment of hereditary angioedema. Haegarda is basically C1 esterase inhibitor protein and it is administered via subcutaneous drug delivery system.

Hereditary angioedema is characterized as rare genetic disorder that causes swelling of extremities, face, reproductive organs and internal lining of airway and gastrointestinal tract. Hereditary angioedema may cause episodal attacks of swelling rather than appearing constantly on skin and other areas.

Exact underlying cause is still unknown but many dermatologists believe that mutations inside C1 inhibitor gene is main triggering factor is this whole phenomenon. Up-til now about more than 300 known mutations have identified is this gene. These mutations bring down the level of C1 inhibitor protein that keeps the inflammatory mediators in control like bradykinin, leukotrienes, histamine etc.

In some cases conditions may become worse due narrowing of airways. This is very serious condition and patient should go to hospital for respiratory support because breathing is almost difficult due to narrowing of airways and internal lining of lungs.

Haegarda is basically C1 esterase inhibitor protein derived from human plasma that maintains its level in case of its deficiency due to mutations in C1 gene. This drug is effective routine attacks of angioedema but not for acute attacks of angioedema.

Haegarda Cost, Side effects, Dosage, Uses for Hereditary Angioedema

Haegarda Side effects


According to health authorities following side effects were reported during its clinical trails

  • Anaphylactic reactions (hypersensitivity)
  • Swelling of nasal lining
  • Dizziness
  • Nasopharyngitis
  • Feeling of swollen throat
  • Itchiness at injection site
  • Rashes
  • Redness of skin
  • Mild Fever in some cases

Haegarda Uses or Prescribing Information


US FDA approved  Haegarda for the treatment of hereditary angioedema in adolescent and adults. This drug should only be used in routine attacks not for acute attacks. It is administered via subcutaneous route. Test dose should be to rule out any possibility of allergic reaction.

Haegarda Dosage


Haegarda is formulated as vial of 2000IU or 3000IU in form of lyophilized powder for reconstitution. However, its dosage frequency is 60IU/Kg subcutaneously two times in a week for the Prophylaxis of hereditary angioedema in adults.

Haegarda Cost/Price


According to market survey this drug is currently not available at retail pharmacies because it is recently approved by FDA and is under manufacturing process. Once, it will be available at retail outlets we will let you know about the unit cost of drug and its dosage frequency.

Kevzara/sarilumab Cost, Side effects, Dosage, Uses for rheumatoid arthritis

Kevzara/sarilumab Cost, Side effects, Dosage, Uses for rheumatoid arthritis. The FDA granted approval of Kevzara to Regeneron Pharmaceutical, Inc., Rensselaer, NY, and Sanofi Winthrop Le Trait, Le Trait, France

US FDA approved new drug Kevzara that contains active pharmaceutical ingredient sarilumab for the treatment of  moderately to severely active rheumatoid arthritis in adult patients who are not responding to disease modifying anti-rheumatic drugs (DMARDs). FDA also indicated that this drug
can be used as single drug therapy or as combination therapy with other anti rheumatic drugs like methotrexate.

Rheumatoid arthritis (RA) is a life-time disease that most commonly affects movable joints of body. Primarily, it is an inflammatory disease manifested as joint swelling, severe pain, stiffness, increase friction and restricted mobility or movement. Major target areas of RA are wrist, hand and ankle joints. Patient may also feel lethargic, reduced energy level, restlessness and fatigue. Symptoms may become severe with passage of time. Treatment of  rheumatoid arthritis mostly consists of disease managements, physiotherapy, exercise and dietary control.

Exact underlying cause of  rheumatoid arthritis is not fully understood but many rheumatologists presume that genetic predisposition, immune system modulation and environmental factors play important role in the pathophysiology of rheumatoid arthritis. Initially, it starts with mild swelling around joints, feeling of joint stiffens right after sleeping and thickening of joint capsule. It is commonly observed that this majorly affects people having age 40 years or more. It has slow onset but longer duration like a chronic disease.

Kevzara/Sarilumab belong to a pharmacological class monoclonal antibody that binds with interleukin-6 receptor and causes inhibition of  IL-6 receptors. Interleukin-6 receptor plays important role in inflammatory response by mediating inflammatory substances such cytokines and
interleukins. Thus, inhibition of interleukin-6 receptor is reduces the process of inflammation of swelling.

Kevzara/sarilumab Cost, Side effects, Dosage, Uses for rheumatoid arthritis


Kevzara/sarilumab Side effects

According to data provided by health authorities this drug exhibit following side effects during clinical trials.

  • Neutopenia
  • Increased liver enzymes (ALT)
  • Reaction at injection site (Erythema)
  • Higher risk of respiratory tract infection
  • Anaphylactic reaction
  • Gastrointestinal perforation
  • Immunosuppression
  • Palpitation 
  • Headache


Kevzara/sarilumab Uses/Patient information

US FDA approved this drug for the treatment of  moderately to severely active rheumatoid arthritis in adult patients who are not responding to disease modifying anti-rheumatic drugs (DMARDs). Data regarding its usage in pregnancy is limited but during initial clinical trails it has been observed that it is actively transported across the placenta during the third trimester of pregnancy.

Kevzara/sarilumab Dosage

Drug is forlumated as 150mg/1.14ml and 200mg/1.14ml as a prefilled syringe. However, standard dosing frequency of this drug is 200mg administer subcutaneously after every two weeks (q2week). Dose titration must be kept in consideration in those patients who have hepatic or renal impairment
or have high ALT or platelets count.

Kevzara/sarilumab Cost/Price

Kevzara is now available in market in two types of strength (potency). Single pack of Kevzara that contains two syringes with potency of 131.6mg/ml costs about 2700$ to 2800$ while Single pack of Kevzara that contains two syringes with potency of 175.4mg/ml costs about 2750$ to 2900$. This price may variate with the passage of time so, make it confirm by visiting your nearby pharmacy before purchasing.

Radicava/edaravone Cost, Side effects, Dosage, Uses for amyotrophic lateral sclerosis (ALS)

Radicava/edaravone Cost, Side effects, Dosage, Uses for amyotrophic lateral sclerosis (ALS). The FDA granted approval of Radicava to Mitsubishi Tanabe Pharma America, Inc.

US FDA approved new drug Radicava that contains active pharmaceutical ingredient edaravone for the treatment of amyotrophic lateral sclerosis (ALS). Radicava/edaravone is categorized as nootropic agent that helps in recovering cerebral damage or degeneration occurs as result of cerebral ischemia, cerebral infarction or any other disorder.

Amyotrophic lateral sclerosis (ALS) also termed as  Lou Gehrig's disease is a rare kind of neuronal problem associated with neuronal death. Neuron is basic unit of nervous system that regulates neuronal transmission required for coordination between body muscles and brain. Amyotrophic lateral sclerosis (ALS) most commonly affects motor neurons that controls body motor functions like driving, walking, speech, breathing etc.

Exact underlying cause is still unknown but many researchers assume that genetic predisposition is key factor in pathogenesis of such disorders. Some other causes that associated with Amyotrophic lateral sclerosis (ALS) are head injury, trauma and branched-chain amino acids enriched diet that induce cellular hyperexcitability. Lesions inside frontotemporal lobes may also be a cause of Amyotrophic lateral sclerosis (ALS).

Initially, it is started as muscular weakness and atropy (decrease in number of cells) . At this time symptoms are very insignificant to feel and patient may overlook these symptoms. when disease progress completely then patine may feel difficulty in walking, speech problems, difficulty with tasks requiring manual dexterity such as buttoning a shirt, writing, or turning a key in a lock may be experienced and muscle spasticity.

Radicava/edaravone Cost, Side effects, Dosage, Uses for amyotrophic lateral sclerosis (ALS)


Radicava/edaravone Side effects


According to data provided by health authorities following side effects were observed during clinical trials

  •     Rash
  •     Hives
  •     Swelling
  •     Shortness of breath
  •     Anaphylaxis
  •     Sodium bisulfite induced allergy
  •     Bruising
  •     Gait disturbance
  •     Nervousness
  •     Loss of appetite
  •     Sleep disturbance

Radicava/edaravone Uses


US FDA approved this drug for the treatment of amyotrophic lateral sclerosis (ALS) to show to slow down functional decline. Radicava/edaravone is free-radical scavenger that is aimed to suppress oxidative degeneration which is a major factor in amyotrophic lateral sclerosis (ALS).

Radicava/edaravone Dosage


This drug is formulated in a single dose polypropylene bag with potency of 30mg/100ml. However, standard dosage frequency of this drug is 60mg as intravenous infusion (IV) over 60 minutes once a day for 14 days followed by a 14-day drug-free period.

Radicava/edaravone Cost/Price

This drug is administered by your healthcare practitioner (HCP), which usually means:
  • It may comes under special items category.
  • You cannot fill this prescription in a regular pharmacy. Your doctor, hospital, or clinic will provide this  medication because of possible complications or other issues.
  • This drug is likely to be covered under your medical benefit if you have insurance.

Tymlos/Abaloparatide Cost, Side effects, Dosage, Uses for postmenopausal osteoporosis

Tymlos/Abaloparatide Cost, Side effects, Dosage, Uses for postmenopausal osteoporosis. US FDA granted approval of Tymlos to Radius Health, Inc.

US FDA approved new medicine Tymlos that contains active pharmaceutical ingredient abaloparatide for the treatment of postmenopausal women with osteoporosis at high risk for fracture. Tymlos/Abaloparatide is parathyroid hormone related protein (PTHrP) and is anabolic agent used to increase bone densification.

Tymlos/Abaloparatide is analogus drug that binds with parathyroid hormone 1 receptor  (PTH1R) which results in activation of Cyclic adenosine monophosphate (cAMP). Cyclic adenosine monophosphate is important compound for intracellular signal transduction in many biological process. This cAMP increase bone densification and mineralization (BMD and BMC) resulting in increase bone strength .

Osteoporosis is worldwide common disease that increase the risk of fractures and bone deformity due to bone demineralization and fragility.  Most commonly affected bones are back bones, forearm bones, hip bone etc. Persistent pain may hinder to carry out routine activities. Osteoporosis symptoms are not obvious initially but later on excessive demineralization may lead to fractures.

Being old, is a major risk factor for osteoporosis. This risk may increase two times in women due to hormonal imbalance after age 40's of 50's. Certain diseases like diabetes, adrenal insufficiency, crohn's disease, coeliac disease, malabsorption disturb calcium phosphorus balance in the body that may lead to osteoporosis if persist for a long term.

TymlosAbaloparatide Cost, Side effects, Dosage, Uses for postmenopausal osteoporosis



Tymlos/Abaloparatide Side effects


According to data provided by health authorities this drug exhibit following side effects during clinical trials
  • Hypercalciuria
  • Dizziness
  • Nausea
  • Headache 
  • Palpitations
  • Fatigue
  • Upper abdominal pain
  • Vertigo
US FDA also instruct for box warning that tymlos/abaloparatide caused a dose-dependent increase in the incidence of osteosarcoma (a malignant bone tumor) in male and female rats; this effect was observed at systemic exposures to abaloparatide ranging from  4-28 times the exposure in humans receiving the 80-mcg dose.


Tymlos/Abaloparatide Uses/Prescribing Information


US FDA approved new medicine Tymlos that contains active pharmaceutical ingredient abaloparatide for the treatment of postmenopausal women with osteoporosis at high risk for fracture. Tymlos/Abaloparatide is parathyroid hormone related protein (PTHrP) and is anabolic agent used to increase bone densification.

Tymlos/Abaloparatide Dosage


This drug is formulated as 80mcg/40mcL (available as a pre-filled pen that delivers 30 daily doses of 80mcg). However, standard dosage frequency is 80mcg subcutaneously once a day. Dose tit-ration should be considered in patient having liver or kidney impairment.

Tymlos/Abaloparatide Cost/Price


Tymlos/Abaloparatide is now available in market. Each pre-filled pen of Tymlos/Abaloparatide has drug voume of 1.56ml. Approximate cost of each pre-filled pen of Tymlos/Abaloparatide is about 1600$ to 1800$. This price may variate with the passage of time so, make it confirm by visiting your nearby pharmacy before purchasing.